... on behalf of the Biochemical Society 2019 hepatocellular carcinoma leukaemia toxicology Bacillus thuringiensis synthesises crystalline parasporal inclusions during sporulation and this salient feature makes it distinguishable from other Bacillus species [ 1 ]. The inclusion proteins have...

... or prolonged exposure to one or multiple compounds. Historically, toxicology studies rely heavily on animal models to understand and characterise the toxicity of novel compounds. However, animal models are imperfect proxies for human toxicity and there have been several high-profile cases of failure of animal...

... cat / K m that was expressed as s −1  M −1  ± SEM. β-carbolines biotransformation detoxification enzyme kinetics methylation toxicology Nicotinamide N -methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to 1-methylnicotinamide (MeN) using S -adenosyl methionine...

... have identified two AHR genes, AHR1 and AHR2, in zebrafish ( Danio rerio ), a widely used model species for studying vertebrate development and an emerging model in developmental toxicology. Zebrafish AHR2 binds TCDD with high affinity, is transcriptionally active and has a major role in mediating...

..., pharmacokinetics, regulation of P450, toxicology. Previously it has been shown by several groups that the levels of human P450 isoforms CYP2A6 [10], CYP2E1 [11] and CYP2D6 [12] that had been expressed in a baculovirus system were significantly reduced upon the expression of recombinant CPR. We observed a similar...