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Keywords: trafficking
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Biochem J (2025) 482 (01): 1–23.
Published: 08 January 2025
... and ** P < 0.01. ( G ) Quantification of the basolateral localization of 3F-MUC17(7TR) in WT and MYO5B –/– Caco-2 cells; n = 6 in each group. Data are presented as mean ± SD and analyzed by unpaired t-test. * P < 0.05. Figure 6: MYO5B regulates 3F-MUC17(7TR) trafficking to the plasma...
Includes: Supplementary data
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Biochem J (2024) 481 (24): 1921–1935.
Published: 09 December 2024
... effects on resumed recovery of trafficking following removal of sERr conditions. Deletion of ERp44 accelerates, while deletion of PDIA6 slows down recovery with a minimal effect on total protein synthesis. ERp44 is a primary interactor with sERr clients. When missing, PDIA6 partitions more into sERr...
Includes: Supplementary data
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Biochem J (2022) 479 (3): 273–288.
Published: 04 February 2022
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane fusion snare proteins trafficking It is well established that Rab GTPases and phosphorylated variants of the membrane lipid phosphatidylinositol (PtdIns) serve as master organizers of vesicle traffic that confer vesicle...
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Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
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Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
... Boucrot ( [email protected] ) Clahtrin-independent endocytosis endophilin FEME trafficking 10 3 2020 11 5 2020 18 5 2020 © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...
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Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...
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Biochem J (2019) 476 (23): 3583–3593.
Published: 03 December 2019
... directionally on the plasma membrane protrusions, supporting a sensory role for filopodia in interpreting local IGF1 gradients. filopodia insulin-like growth factor receptors trafficking Filopodia are thin membrane protrusions of 100 to 200 nm diameter, containing 10–30 actin filaments bundled...
Includes: Supplementary data
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Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
... mitochondria and elsewhere. 20 6 2018 23 11 2018 27 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cellular localisation mitochondria mtDNA multifunctional proteins trafficking transport Historically...
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Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
... (LI-COR) and were quantified by densitometric analysis using Image Studio Software (LI-COR). endocytosis GTPases intracellular signaling membranes trafficking Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is a member of the LDL receptor gene family and is expressed...
Includes: Supplementary data
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Biochem J (2017) 474 (24): 4105–4118.
Published: 06 December 2017
...). Published by Portland Press Limited on behalf of the Biochemical Society 2017 insulin-like growth factor receptor tyrosine kinases trafficking turnover Ubiquilin IGF1R (insulin-like growth factor-1 receptor) is a receptor tyrosine kinase ubiquitously expressed on cell surfaces of all...
Includes: Supplementary data
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Biochem J (2017) 474 (21): 3615–3626.
Published: 23 October 2017
... proteins tethering complexes trafficking Eukaryotic cells exert tight control over the fusion of their membrane-bound compartments. SNARE-mediated membrane fusion events are regulated by multiple proteins [ 1 , 2 ], including multisubunit membrane tethering complexes. The class C core vacuole...
Includes: Supplementary data
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Biochem J (2016) 473 (3): 233–244.
Published: 25 January 2016
... in functional system b 0,+ . This leads to the formation of kidney cystine stones, the clinical sign of the disease [ 10 ]. Type I cystinuria is caused mainly by mutations in rBAT. Most of them are found in the ectodomain and cause folding/trafficking defects [ 11 ]. There is therefore great interest...
Includes: Supplementary data
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Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
... acid residues mediating ATP sensitivity Purinergic Signal. 2012 8 81 90 10.1007/s11302-011-9263-6 21987098 18 Kochukov M.Y. Ritchie A.K. A P2X7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line Am. J. Physiol. Cell Physiol. 2004 287 C992...
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Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1 (Panx1) proteins come together to form channels that facilitate the regulated passage of Ca 2+ and small molecules across...
Includes: Multimedia, Supplementary data
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Biochem J (2015) 467 (1): 127–139.
Published: 20 March 2015
...) transporter ATP-binding cassette subfamily B (ABCB) 6 lysosome trafficking transmembrane domain ATP-binding cassette (ABC) transporters are large membrane-spanning multidomain proteins promoting the ATP-dependent transmembrane transport of a vast array of biological compounds, including drugs...
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Biochem J (2015) 465 (3): 471–477.
Published: 22 January 2015
... promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors remains unclear. In the present study, we examined the effect of TARP glycosylation on AMPA receptor trafficking. We first showed that TARP γ-8 is an N-glycosylated protein, which contains two...
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Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
..., although the downstream substrates mediating this function are not yet clear. In the present paper, we report the lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons. GSK3...
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Biochem J (2014) 463 (3): 339–349.
Published: 10 October 2014
.... dynactin Na v 1.5 protein complex sodium channel trafficking 12 5 2014 25 7 2014 4 8 2014 4 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 The voltage-gated sodium channel Na v 1.5 is responsible for action potential generation...
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Biochem J (2014) 458 (3): 513–523.
Published: 28 February 2014
... synthetase apicoplast Apicomplexa dual-targeted Plasmodium Toxoplasma gondii trafficking tRNA In eukaryotes, translation occurs in mitochondria, plastids and the cytosol. Translation in each of these compartments requires aaRSs. With few exceptions, organellar aaRSs are encoded in the nuclear...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
...–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent and widespread Ca 2+ -mobilizing messenger [ 1 ]. It regulates processes as diverse as fertilization and differentiation [ 2 – 4 ]. Intriguingly...
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Biochem J (2012) 445 (1): 101–111.
Published: 15 June 2012
... monomers. Although this cysteine seems not to be involved in regulation of trafficking to the plasma membrane, activity, substrate selectivity or oxidative gating of ZmPIP1s (Zm is Zea mays ), ZmPIP2s and hetero-oligomers, it increases oligomer stability under denaturating conditions. In addition, when...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 335–343.
Published: 13 February 2012
... from HemW in vitro . On the basis of these findings, we propose a role of HemW in haem trafficking. HemW-like proteins form a distinct phylogenetic clade that has not previously been recognized. hemW -like genes are widespread in Gram-positive and Gram-negative bacteria. In Bacillus subtilis...
Includes: Supplementary data
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Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... with 10% FCS supplemented with 10% conditioned medium from WEHI-3B cells as a source for IL (interleukin)-3. endoplasmic reticulum post-translational modification signalling trafficking ubiquitin vesicular stomatitis virus glycoprotein Lysine residues are key residues in many cellular...
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Biochem J (2010) 426 (3): 379–388.
Published: 24 February 2010
... heterodimers. Therefore the patient carries one kAE1 mutant that is retained in the Golgi (G701D) and another kAE1 mutant (C479W) located in the endoplasmic reticulum of kidney cells, and is thus probably unable to reabsorb bicarbonate into the blood. We conclude that the C479W mutant is a novel trafficking...
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Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... The Authors Journal compilation © 2010 Biochemical Society 2010 endoplasmic reticulum oxidoreductase protein disulfide isomerase (PDI) thioredoxin thioredoxin-like transmembrane protein 4 (TMX4) trafficking The relatively oxidizing conditions inside the lumen of the ER (endoplasmic...
Includes: Supplementary data
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Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... mutant failed to co-localize with Rab11 and recycle to the plasma membrane, in contrast with the wild-type receptor. To our knowledge, the present study is the first report of a direct interaction between the β2AR and a Rab GTPase, which is required for the accurate intracellular trafficking...
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Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...Kathryn A. Stern; Trenton L. Place; Nancy L. Lill EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking...
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Biochem J (2008) 409 (2): 555–562.
Published: 21 December 2007
... GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that stably expresses inducible temperature-sensitive GPI...
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Biochem J (2007) 407 (2): 171–177.
Published: 25 September 2007
... compilation © 2007 Biochemical Society 2007 furin MT1-MMP (membrane-type 1 matrix metalloproteinase) α1-PI (α1-proteinase inhibitor) trafficking MMPs (matrix metalloproteinases) are a family of zinc-dependent metalloendopeptidases that process a variety of substrates, including proMMP...
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Biochem J (2007) 406 (1): 157–165.
Published: 26 July 2007
... components, some gaps are found that cannot be explained in a working model for vesicle trafficking regulation. One of these void spaces is the production of DAG, which is not only necessary to activate PKC, but also to recruit PKD to Golgi membranes in order to be activated and generate vesicle fission...
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Biochem J (2007) 404 (3): 525–534.
Published: 29 May 2007
... the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and α-SNAP (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I...
Includes: Supplementary data
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Biochem J (2005) 392 (3): 475–483.
Published: 06 December 2005
... trafficking In eukaryotic cells, mRNA localization to different regions in the cytoplasm provides a mechanism for synthesis of proteins close to where they are required [ 1 – 3 ]. For example, in fibroblasts some mRNAs, such as those encoding β-actin and creatine kinase isoform M, are transported...
Includes: Supplementary data
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Biochem J (2000) 350 (2): 337–352.
Published: 23 August 2000
... reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae . 1 To whom correspondence should be addressed. The Biochemical Society, London © 2000 2000 actin endocytosis exocytosis phosphoinositide trafficking Biochem. J. (2000) 350, 337...