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Keywords: trafficking
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (01): 1–23.
Published: 08 January 2025
... ]. To determine the impact of MYO5B on MUC17 trafficking, we stained for endogenous Muc17 and Ezrin in ileal sections of Myo5b fl/fl ;Vil1-CreERT mice injected with vehicle or tamoxifen to induce deletion of the Myo5b gene in Vil1 -expressing intestinal epithelial cells. In Myo5b fl/fl ;Vil1-CreERT mice...
Includes: Supplementary data
Articles
Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6
Available to PurchaseOlaya Yassin, Bellam Praveen, Odai Darawshi, Thomas LaFramboise, Miriam Shmuel, Shakti P. Pattanayak, Brian K. Law, Maria Hatzoglou, Boaz Tirosh
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 1921–1935.
Published: 09 December 2024
... effects on resumed recovery of trafficking following removal of sERr conditions. Deletion of ERp44 accelerates, while deletion of PDIA6 slows down recovery with a minimal effect on total protein synthesis. ERp44 is a primary interactor with sERr clients. When missing, PDIA6 partitions more into sERr...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (19): 1297–1325.
Published: 20 September 2024
... are transmembrane proteins and their co-localisation in the same membrane-bound sub-compartment is necessary for APP cleavage. The intracellular trafficking of APP and the β-secretase, BACE1, is critical in regulating APP processing and Aβ production and has been studied in several cellular systems. Here, we...
Articles
SNARE proteins: zip codes in vesicle targeting?
Open Access
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 273–288.
Published: 04 February 2022
... as targeting signals in vesicle traffic. Correspondence: Reinhard Jahn ([email protected]) membrane fusion snare proteins trafficking 12 10 2021 1 12 2021 22 12 2021 © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf...
Articles
FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells
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Journal:
Biochemical Journal
Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
... access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. Clahtrin-independent endocytosis endophilin FEME trafficking...
Articles
Cell-penetrating peptides: two faces of the same coin
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Journal:
Biochemical Journal
Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... specificity, low selectivity for intracellular targets, and low stability in the bloodstream. cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active peptide, named EJP18, which...
Articles
IGF1R undergoes active and directed centripetal transport on filopodia upon receptor activation
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Journal:
Biochemical Journal
Biochem J (2019) 476 (23): 3583–3593.
Published: 03 December 2019
... and migration in zebrafish [ 13 ]. Clearance of activated signaling receptors from filopodia has been suggested as a potential mechanism for the proposed sensing role of filopodia [ 14 ]. filopodia insulin-like growth factor receptors trafficking © 2019 The Author(s). Published by Portland Press...
Includes: Supplementary data
Articles
Strangers in strange lands: mitochondrial proteins found at extra-mitochondrial locations
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
... ], de novo protein folding [ 26 ], and intracellular trafficking [ 27 ]. It is predominantly localised to the mitochondrial matrix [ 28 ], where it is an essential component of the mitochondrial protein import pathway [ 29 ]. Newly synthesised mortalin has an N-terminal presequence that is cleaved off...
Articles
Insulin-induced exocytosis regulates the cell surface level of low-density lipoprotein-related protein-1 in Müller Glial cells
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Journal:
Biochemical Journal
Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
... experiments were carried out with MIO-M1 cells transfected with the mLRP4-GFP-HA plasmid and polyclonal rabbit anti-HA-tag antibody (1/1000). endocytosis GTPases intracellular signaling membranes trafficking Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is a member...
Includes: Supplementary data
Articles
Regulation of insulin-like growth factor receptors by Ubiquilin1
Available to PurchaseZimple Kurlawala, Rain Dunaway, Parag P. Shah, Julie A. Gosney, Leah J. Siskind, Brian P. Ceresa, Levi J. Beverly
Journal:
Biochemical Journal
Biochem J (2017) 474 (24): 4105–4118.
Published: 06 December 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 insulin-like growth factor receptor tyrosine kinases trafficking turnover Ubiquilin A549 cells expressing UBQLN1 shRNA (shUBQLN1, shUBQLN2 and control) (2 × 10 4 cells) were seeded onto 96-well plate and cultured for 4 days...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3615–3626.
Published: 23 October 2017
..., Vps39 appears to only contact Vps11 at the opposite (‘tail’) end of the complex. To date, the structure of mammalian HOPS has been assumed to be the same as that of the yeast HOPS complex. However, there is evidence of evolutionary divergence within the membrane trafficking system. Metazoan VPS33A...
Includes: Supplementary data
Articles
The role of N-glycans and the C-terminal loop of the subunit rBAT in the biogenesis of the cystinuria-associated transporter
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Journal:
Biochemical Journal
Biochem J (2016) 473 (3): 233–244.
Published: 25 January 2016
... system b 0,+ impair its biogenesis, causing cystinuria. We show that a specific N-glycan and the C-terminal disulfide loop of the helper subunit are key elements for biogenesis of system b 0,+ . cystinuria endoplasmic reticulum folding N-linked glycosylation trafficking transporter...
Includes: Supplementary data
Articles
Interdependence of ATP signalling and pannexin channels; the servant was really the master all along?
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Journal:
Biochemical Journal
Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
.... Dahl G. Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity Purinergic Signal. 2012 8 81 90 10.1007/s11302-011-9263-6 21987098 18 Kochukov M.Y. Ritchie A.K. A P2X7 receptor stimulates plasma membrane trafficking in the FRTL rat...
Articles
ATP stimulates pannexin 1 internalization to endosomal compartments
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Journal:
Biochemical Journal
Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... pannexin1 trafficking Six individual pannexin 1 (Panx1) proteins come together to form channels that facilitate the regulated passage of Ca 2+ and small molecules across the plasma membrane in cells throughout the body [ 1 ]. Panx1 channels are perhaps best known for their association with ATP...
Includes: Multimedia, Supplementary data
Articles
Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation
Available to PurchaseJeyaganesh Rajamanickam, Balasubramaniam Annamalai, Troels Rahbek-Clemmensen, Santhanalakshmi Sundaramurthy, Ulrik Gether, Lankupalle D. Jayanthi, Sammanda Ramamoorthy
Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 177–190.
Published: 05 May 2015
... clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary targets for antidepressants for therapeutic intervention of mood disorders. Our previous studies have identified the involvement of several signalling pathways and protein kinases in regulating SERT function, trafficking...
Articles
Katalin Kiss, Nora Kucsma, Anna Brozik, Gabor E. Tusnady, Ptissam Bergam, Guillaume van Niel, Gergely Szakacs
Journal:
Biochemical Journal
Biochem J (2015) 467 (1): 127–139.
Published: 20 March 2015
... trafficking transmembrane domain ATP-binding cassette (ABC) transporters are large membrane-spanning multidomain proteins promoting the ATP-dependent transmembrane transport of a vast array of biological compounds, including drugs, bile acids, peptides, steroids, ions and phospholipids [ 1...
Articles
TARP γ-8 glycosylation regulates the surface expression of AMPA receptors
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Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 471–477.
Published: 22 January 2015
... promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors remains unclear. In the present study, we examined the effect of TARP glycosylation on AMPA receptor trafficking. We first showed that TARP γ-8 is an N-glycosylated protein, which contains two...
Articles
PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes
Available to PurchaseJames W. Robinson, Iryna Leshchyns’ka, Hovik Farghaian, William E. Hughes, Vladimir Sytnyk, Graham G. Neely, Adam R. Cole
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
..., although the downstream substrates mediating this function are not yet clear. In the present paper, we report the lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons. GSK3...
Articles
Dynamitin affects cell-surface expression of voltage-gated sodium channel Na v 1.5
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Journal:
Biochemical Journal
Biochem J (2014) 463 (3): 339–349.
Published: 10 October 2014
... with dynamitin, a member of the microtubule-associated dynactin complex whose disruption affects the channel cell-surface density. dynactin Na v 1.5 protein complex sodium channel trafficking The yeast reporter strain L40, which contains the reporter gene HIS3 downstream of the binding sequence...
Articles
Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1
Available to PurchaseStephen C. Harmer, Jagdeep S. Mohal, Alice A. Royal, William J. McKenna, Pier D. Lambiase, Andrew Tinker
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 133–142.
Published: 24 July 2014
.... LQT1 compound mutations have been shown to increase channel dysfunction, but whether other disease mechanisms, such as defective channel trafficking, contribute to the increase in arrhythmic risk has not been determined. Using an imaging-based assay we investigated the effects of four compound...
Articles
A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNA Cys
Available to PurchaseJames S. Pham, Reiko Sakaguchi, Lee M. Yeoh, Nilushi S. De Silva, Geoffrey I. McFadden, Ya-Ming Hou, Stuart A. Ralph
Journal:
Biochemical Journal
Biochem J (2014) 458 (3): 513–523.
Published: 28 February 2014
... targeting is mediated by a very different sequence: a bipartite leader consisting of a signal peptide followed by a transit peptide [ 16 , 17 ]. Hence, apicoplast trafficking sequences are very unlikely to function as mitochondrial import elements, or to allow easy partitioning between apicoplast...
Includes: Multimedia, Supplementary data
Articles
Spinocerebellar ataxia-13 K v 3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface
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Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 259–265.
Published: 09 August 2013
... side chain spinocerebellar ataxia type 13 (SCA13) trafficking Figure 1 SCA13 R366H, R420H and R423H mutations significantly decrease cell-surface expression of K v 3.3, whereas F448L does not ( A ) Location of SCA13 mutations on a schematic model of one K v 3.3 subunit. Point mutations found...
Articles
The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP
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Journal:
Biochemical Journal
Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
... 5 2013 2 5 2013 2 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium endosome lysosome nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide...
Articles
A conserved cysteine residue is involved in disulfide bond formation between plant plasma membrane aquaporin monomers
Available to PurchaseGerd P. Bienert, Damien Cavez, Arnaud Besserer, Marie C. Berny, Dimitri Gilis, Marianne Rooman, François Chaumont
Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 101–111.
Published: 15 June 2012
... monomers. Although this cysteine seems not to be involved in regulation of trafficking to the plasma membrane, activity, substrate selectivity or oxidative gating of ZmPIP1s (Zm is Zea mays ), ZmPIP2s and hetero-oligomers, it increases oligomer stability under denaturating conditions. In addition, when...
Includes: Supplementary data
Articles
Lactococcus lactis HemW (HemN) is a haem-binding protein with a putative role in haem trafficking
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Journal:
Biochemical Journal
Biochem J (2012) 442 (2): 335–343.
Published: 13 February 2012
... from HemW in vitro . On the basis of these findings, we propose a role of HemW in haem trafficking. HemW-like proteins form a distinct phylogenetic clade that has not previously been recognized. hemW -like genes are widespread in Gram-positive and Gram-negative bacteria. In Bacillus subtilis...
Includes: Supplementary data
Articles
Cytosolic lysine residues enhance anterograde transport and activation of the erythropoietin receptor
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Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... should be addressed (email [email protected] ). 16 11 2010 20 1 2011 3 2 2011 3 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum post-translational modification signalling trafficking ubiquitin vesicular stomatitis...
Articles
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
Available to PurchaseEbru Boslem, Gemma MacIntosh, Amanda M. Preston, Clarissa Bartley, Anna K. Busch, Maria Fuller, D. Ross Laybutt, Peter J. Meikle, Trevor J. Biden
Journal:
Biochemical Journal
Biochem J (2011) 435 (1): 267–276.
Published: 15 March 2011
...-to-Golgi protein trafficking was also reduced by palmitate pre-treatment, but was overcome by overexpression of GlcCer synthase. This was accompanied by increased conversion of ceramide into GlcCer, and reduced ER stress and apoptosis, but no change in phospholipid desaturation. Sphingolipid alterations...
Includes: Supplementary data
Articles
Band 3 Edmonton I, a novel mutant of the anion exchanger 1 causing spherocytosis and distal renal tubular acidosis
Available to PurchaseCarmen Chu, Naomi Woods, Nunghathai Sawasdee, Helene Guizouarn, Bernard Pellissier, Franck Borgese, Pa-thai Yenchitsomanus, Manjula Gowrishankar, Emmanuelle Cordat
Journal:
Biochemical Journal
Biochem J (2010) 426 (3): 379–388.
Published: 24 February 2010
... heterodimers. Therefore the patient carries one kAE1 mutant that is retained in the Golgi (G701D) and another kAE1 mutant (C479W) located in the endoplasmic reticulum of kidney cells, and is thus probably unable to reabsorb bicarbonate into the blood. We conclude that the C479W mutant is a novel trafficking...
Articles
A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4
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Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... The Authors Journal compilation © 2010 Biochemical Society 2010 endoplasmic reticulum oxidoreductase protein disulfide isomerase (PDI) thioredoxin thioredoxin-like transmembrane protein 4 (TMX4) trafficking The relatively oxidizing conditions inside the lumen of the ER (endoplasmic...
Includes: Supplementary data
Articles
Rab11 regulates the recycling of the β 2 -adrenergic receptor through a direct interaction
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Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... mutant failed to co-localize with Rab11 and recycle to the plasma membrane, in contrast with the wild-type receptor. To our knowledge, the present study is the first report of a direct interaction between the β2AR and a Rab GTPase, which is required for the accurate intracellular trafficking...
Articles
A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes
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Journal:
Biochemical Journal
Biochem J (2008) 414 (3): 431–440.
Published: 27 August 2008
... 2007 12 5 2008 14 5 2008 14 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 dileucine signal lysosome membrane p40 trafficking The labelling with Texas Red-dextran of HeLa cells transfected with p40–GFP constructs was performed...
Articles
Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b
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Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 469–475.
Published: 28 May 2008
... are glycoproteins, and N-glycans can serve many functions. Among them, they can aid the proper folding of the protein, stabilize the structure of the protein and promote its intracellular trafficking [ 15 , 16 ]. Some glycoproteins strictly depend on N-glycans for their function [ 17 – 19 ], whereas N-glycans...
Articles
Trafficking properties and activity regulation of the neuronal glycine transporter GLYT2 by protein kinase C
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Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 495–506.
Published: 28 May 2008
... is located in membrane rafts and reaches the cell surface through intracellular trafficking. In the present study we prove that GLYT2 constitutively recycles between the cell interior and the plasma membrane by means of a monensin-sensitive trafficking pathway. Also, a regulated trafficking can be triggered...
Articles
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate
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Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...Kathryn A. Stern; Trenton L. Place; Nancy L. Lill EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking...
Articles
Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells
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Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 463–472.
Published: 27 February 2008
... manner in living cells and propose that ACBP may be involved in vesicular trafficking. 1 To whom correspondence should be addressed (email [email protected] ). 25 4 2007 4 10 2007 22 10 2007 22 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008...
Includes: Supplementary data
Articles
Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane
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Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 555–562.
Published: 21 December 2007
... GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that stably expresses inducible temperature-sensitive GPI...
Articles
The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies
Available to PurchaseGina E. Sosinsky, Joell L. Solan, Guido M. Gaietta, Lucy Ngan, Grace J. Lee, Mason R. Mackey, Paul D. Lampe
Journal:
Biochemical Journal
Biochem J (2007) 408 (3): 375–385.
Published: 28 November 2007
... of connexin trafficking and channel gating. It is well-documented that SDS/PAGE of NRK (normal rat kidney) cell lysates reveals at least three connexin43-specific bands (P0, P1 and P2). P1 and P2 are phosphorylated on multiple, unidentified serine residues and are found primarily in gap-junction plaques...
Articles
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking
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Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 171–177.
Published: 25 September 2007
... [email protected] ). 23 4 2007 18 7 2007 25 7 2007 25 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 furin MT1-MMP (membrane-type 1 matrix metalloproteinase) α1-PI (α1-proteinase inhibitor) trafficking MMPs (matrix...
Articles
Phospholipase C β3 is a key component in the Gβγ/PKCη/PKD-mediated regulation of trans -Golgi network to plasma membrane transport
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Journal:
Biochemical Journal
Biochem J (2007) 406 (1): 157–165.
Published: 26 July 2007
...) trafficking Since the discovery of IQ (ilimaquinone)'s role in Golgi fragmentation [ 1 ], a wide variety of new vesicle trafficking regulatory proteins have been found and their cellular localization and physical interactions described, which led to the understanding of how the pathway involving...
Articles
Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2
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Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 525–534.
Published: 29 May 2007
... the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and α-SNAP (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I...
Includes: Supplementary data
Articles
Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells
Available to PurchaseSonia Fernández-Veledo, Isabel Huber-Ruano, Ivette Aymerich, Sylvie Duflot, F. Javier Casado, Marçal Pastor-Anglada
Journal:
Biochemical Journal
Biochem J (2006) 395 (2): 337–344.
Published: 28 March 2006
... protein may play additional roles other than nucleoside salvage, since it has recently been shown to be under purinergic control via K ATP channels, by a mechanism that does not seem to involve changes in its subcellular localization. In an attempt to identify the agents that promote CNT2 trafficking...
Articles
An AU-rich stem–loop structure is a critical feature of the perinuclear localization signal of c- myc mRNA
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Journal:
Biochemical Journal
Biochem J (2005) 392 (3): 475–483.
Published: 06 December 2005
... localization trafficking In eukaryotic cells, mRNA localization to different regions in the cytoplasm provides a mechanism for synthesis of proteins close to where they are required [ 1 – 3 ]. For example, in fibroblasts some mRNAs, such as those encoding β-actin and creatine kinase isoform M...
Includes: Supplementary data
Articles
Amino acids in the pore region of Kv1 potassium channels dictate cell-surface protein levels: a possible trafficking code in the Kv1 subfamily
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Journal:
Biochemical Journal
Biochem J (2005) 388 (1): 355–362.
Published: 10 May 2005
..., Watanabe, Gomez and Thornhill (2003) J. Biol. Chem. 278 , 25558–25567; Zhu, Watanabe, Gomez and Thornhill (2003) Biochem. J. 375 , 761–768]. In the present study, we focused on the deep pore region of Kv1 members to test whether a cell-surface trafficking code was dictated by two amino acids. Kv1 channels...
Articles
Functional interaction between p75 NTR and TrkA: the endocytic trafficking of p75 NTR is driven by TrkA and regulates TrkA-mediated signalling
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Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 233–241.
Published: 14 December 2004
...Lorena PERRONE; Simona PALADINO; Marialuisa MAZZONE; Lucio NITSCH; Massimo GULISANO; Chiara ZURZOLO The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling...
Articles
Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites
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Journal:
Biochemical Journal
Biochem J (2004) 380 (3): 805–813.
Published: 15 June 2004
... in close proximity to the canalicular membrane to facilitate biliary copper excretion. In the present study, we investigated the role of the six N-terminal MBSs (metal-binding sites) in the trafficking process. Using site-directed mutagenesis, we mutated or deleted various combinations of the MBSs...
Articles
Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool
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Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 1031–1037.
Published: 15 March 2004
... in the Golgi compartment and effluxes excess copper from the cell. These roles can be achieved through copper-regulated trafficking of MNK. It has previously been shown to undergo trafficking from the trans -Golgi network to the plasma membrane in response to elevated copper concentrations...
Articles
Trafficking of Kv1.4 potassium channels: interdependence of a pore region determinant and a cytoplasmic C-terminal VXXSL determinant in regulating cell-surface trafficking
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Journal:
Biochemical Journal
Biochem J (2003) 375 (3): 761–768.
Published: 01 November 2003
...Jing ZHU; Itaru WATANABE; Barbara GOMEZ; William B. THORNHILL Kv1.4 and Kv1.1 potassium channel homomers have been shown to exhibit different intracellular trafficking programmes and cell-surface expression levels in cell lines: a determinant in the pore region of Kv1.4 and Kv1.1 [Zhu, Watanabe...
Articles
Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells
Available to PurchasePenelope BUXTON, Xiang-Ming ZHANG, Bong WALSH, Absorn SRIRATANA, Irina SCHENBERG, Elizabeth MANICKAM, Tony ROWE
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 433–440.
Published: 15 October 2003
... neurosecretion. Key words: exocytosis, soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE), synapto- some-associated protein-23 (SNAP23), syntaxin, trafficking, vesicle. INTRODUCTION The trafficking of proteins and lipids between organelles is mediated by transport vesicles...
Articles
Sac phosphatase domain proteins
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Journal:
Biochemical Journal
Biochem J (2000) 350 (2): 337–352.
Published: 23 August 2000
... reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae . actin endocytosis exocytosis phosphoinositide trafficking Biochem. J. (2000) 350, 337 352 (Printed in Great Britain) 337 REVIEW ARTICLE Sac phosphatase domain proteins William E. HUGHES...
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