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Keywords: trafficking
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (01): 1–23.
Published: 08 January 2025
... and ** P < 0.01. ( G ) Quantification of the basolateral localization of 3F-MUC17(7TR) in WT and MYO5B –/– Caco-2 cells; n = 6 in each group. Data are presented as mean ± SD and analyzed by unpaired t-test. * P < 0.05. Figure 6: MYO5B regulates 3F-MUC17(7TR) trafficking to the plasma...
Includes: Supplementary data
Articles
Olaya Yassin, Bellam Praveen, Odai Darawshi, Thomas LaFramboise, Miriam Shmuel, Shakti P. Pattanayak, Brian K. Law, Maria Hatzoglou, Boaz Tirosh
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 1921–1935.
Published: 09 December 2024
... effects on resumed recovery of trafficking following removal of sERr conditions. Deletion of ERp44 accelerates, while deletion of PDIA6 slows down recovery with a minimal effect on total protein synthesis. ERp44 is a primary interactor with sERr clients. When missing, PDIA6 partitions more into sERr...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (19): 1297–1325.
Published: 20 September 2024
... are transmembrane proteins and their co-localisation in the same membrane-bound sub-compartment is necessary for APP cleavage. The intracellular trafficking of APP and the β-secretase, BACE1, is critical in regulating APP processing and Aβ production and has been studied in several cellular systems. Here, we...
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 273–288.
Published: 04 February 2022
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane fusion snare proteins trafficking It is well established that Rab GTPases and phosphorylated variants of the membrane lipid phosphatidylinositol (PtdIns) serve as master organizers of vesicle traffic that confer vesicle...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
... Boucrot ( [email protected] ) Clahtrin-independent endocytosis endophilin FEME trafficking 10 3 2020 11 5 2020 18 5 2020 © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (23): 3583–3593.
Published: 03 December 2019
... directionally on the plasma membrane protrusions, supporting a sensory role for filopodia in interpreting local IGF1 gradients. filopodia insulin-like growth factor receptors trafficking Filopodia are thin membrane protrusions of 100 to 200 nm diameter, containing 10–30 actin filaments bundled...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
... mitochondria and elsewhere. 20 6 2018 23 11 2018 27 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cellular localisation mitochondria mtDNA multifunctional proteins trafficking transport Historically...
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
... (LI-COR) and were quantified by densitometric analysis using Image Studio Software (LI-COR). endocytosis GTPases intracellular signaling membranes trafficking Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is a member of the LDL receptor gene family and is expressed...
Includes: Supplementary data
Articles
Zimple Kurlawala, Rain Dunaway, Parag P. Shah, Julie A. Gosney, Leah J. Siskind, Brian P. Ceresa, Levi J. Beverly
Journal:
Biochemical Journal
Biochem J (2017) 474 (24): 4105–4118.
Published: 06 December 2017
...). Published by Portland Press Limited on behalf of the Biochemical Society 2017 insulin-like growth factor receptor tyrosine kinases trafficking turnover Ubiquilin IGF1R (insulin-like growth factor-1 receptor) is a receptor tyrosine kinase ubiquitously expressed on cell surfaces of all...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3615–3626.
Published: 23 October 2017
... proteins tethering complexes trafficking Eukaryotic cells exert tight control over the fusion of their membrane-bound compartments. SNARE-mediated membrane fusion events are regulated by multiple proteins [ 1 , 2 ], including multisubunit membrane tethering complexes. The class C core vacuole...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (3): 233–244.
Published: 25 January 2016
... in functional system b 0,+ . This leads to the formation of kidney cystine stones, the clinical sign of the disease [ 10 ]. Type I cystinuria is caused mainly by mutations in rBAT. Most of them are found in the ectodomain and cause folding/trafficking defects [ 11 ]. There is therefore great interest...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
... acid residues mediating ATP sensitivity Purinergic Signal. 2012 8 81 90 10.1007/s11302-011-9263-6 21987098 18 Kochukov M.Y. Ritchie A.K. A P2X7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line Am. J. Physiol. Cell Physiol. 2004 287 C992...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1 (Panx1) proteins come together to form channels that facilitate the regulated passage of Ca 2+ and small molecules across...
Includes: Multimedia, Supplementary data
Articles
Jeyaganesh Rajamanickam, Balasubramaniam Annamalai, Troels Rahbek-Clemmensen, Santhanalakshmi Sundaramurthy, Ulrik Gether, Lankupalle D. Jayanthi, Sammanda Ramamoorthy
Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 177–190.
Published: 05 May 2015
... clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary targets for antidepressants for therapeutic intervention of mood disorders. Our previous studies have identified the involvement of several signalling pathways and protein kinases in regulating SERT function, trafficking...
Articles
Katalin Kiss, Nora Kucsma, Anna Brozik, Gabor E. Tusnady, Ptissam Bergam, Guillaume van Niel, Gergely Szakacs
Journal:
Biochemical Journal
Biochem J (2015) 467 (1): 127–139.
Published: 20 March 2015
...) transporter ATP-binding cassette subfamily B (ABCB) 6 lysosome trafficking transmembrane domain ATP-binding cassette (ABC) transporters are large membrane-spanning multidomain proteins promoting the ATP-dependent transmembrane transport of a vast array of biological compounds, including drugs...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 471–477.
Published: 22 January 2015
... promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors remains unclear. In the present study, we examined the effect of TARP glycosylation on AMPA receptor trafficking. We first showed that TARP γ-8 is an N-glycosylated protein, which contains two...
Articles
James W. Robinson, Iryna Leshchyns’ka, Hovik Farghaian, William E. Hughes, Vladimir Sytnyk, Graham G. Neely, Adam R. Cole
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
..., although the downstream substrates mediating this function are not yet clear. In the present paper, we report the lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons. GSK3...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (3): 339–349.
Published: 10 October 2014
.... dynactin Na v 1.5 protein complex sodium channel trafficking 12 5 2014 25 7 2014 4 8 2014 4 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 The voltage-gated sodium channel Na v 1.5 is responsible for action potential generation...
Articles
Stephen C. Harmer, Jagdeep S. Mohal, Alice A. Royal, William J. McKenna, Pier D. Lambiase, Andrew Tinker
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 133–142.
Published: 24 July 2014
.... LQT1 compound mutations have been shown to increase channel dysfunction, but whether other disease mechanisms, such as defective channel trafficking, contribute to the increase in arrhythmic risk has not been determined. Using an imaging-based assay we investigated the effects of four compound...
Articles
James S. Pham, Reiko Sakaguchi, Lee M. Yeoh, Nilushi S. De Silva, Geoffrey I. McFadden, Ya-Ming Hou, Stuart A. Ralph
Journal:
Biochemical Journal
Biochem J (2014) 458 (3): 513–523.
Published: 28 February 2014
... synthetase apicoplast Apicomplexa dual-targeted Plasmodium Toxoplasma gondii trafficking tRNA In eukaryotes, translation occurs in mitochondria, plastids and the cytosol. Translation in each of these compartments requires aaRSs. With few exceptions, organellar aaRSs are encoded in the nuclear...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 259–265.
Published: 09 August 2013
... stability side chain spinocerebellar ataxia type 13 (SCA13) trafficking Voltage-gated potassium (K v ) channels are a large family of ion channels that play a major role in setting the resting membrane potential and the threshold and firing pattern of action potentials [ 1 ]. The K v 3 subfamily...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
...–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent and widespread Ca 2+ -mobilizing messenger [ 1 ]. It regulates processes as diverse as fertilization and differentiation [ 2 – 4 ]. Intriguingly...
Articles
Gerd P. Bienert, Damien Cavez, Arnaud Besserer, Marie C. Berny, Dimitri Gilis, Marianne Rooman, François Chaumont
Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 101–111.
Published: 15 June 2012
... monomers. Although this cysteine seems not to be involved in regulation of trafficking to the plasma membrane, activity, substrate selectivity or oxidative gating of ZmPIP1s (Zm is Zea mays ), ZmPIP2s and hetero-oligomers, it increases oligomer stability under denaturating conditions. In addition, when...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 442 (2): 335–343.
Published: 13 February 2012
... from HemW in vitro . On the basis of these findings, we propose a role of HemW in haem trafficking. HemW-like proteins form a distinct phylogenetic clade that has not previously been recognized. hemW -like genes are widespread in Gram-positive and Gram-negative bacteria. In Bacillus subtilis...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... with 10% FCS supplemented with 10% conditioned medium from WEHI-3B cells as a source for IL (interleukin)-3. endoplasmic reticulum post-translational modification signalling trafficking ubiquitin vesicular stomatitis virus glycoprotein Lysine residues are key residues in many cellular...
Articles
Ebru Boslem, Gemma MacIntosh, Amanda M. Preston, Clarissa Bartley, Anna K. Busch, Maria Fuller, D. Ross Laybutt, Peter J. Meikle, Trevor J. Biden
Journal:
Biochemical Journal
Biochem J (2011) 435 (1): 267–276.
Published: 15 March 2011
...-to-Golgi protein trafficking was also reduced by palmitate pre-treatment, but was overcome by overexpression of GlcCer synthase. This was accompanied by increased conversion of ceramide into GlcCer, and reduced ER stress and apoptosis, but no change in phospholipid desaturation. Sphingolipid alterations...
Includes: Supplementary data
Articles
Carmen Chu, Naomi Woods, Nunghathai Sawasdee, Helene Guizouarn, Bernard Pellissier, Franck Borgese, Pa-thai Yenchitsomanus, Manjula Gowrishankar, Emmanuelle Cordat
Journal:
Biochemical Journal
Biochem J (2010) 426 (3): 379–388.
Published: 24 February 2010
... heterodimers. Therefore the patient carries one kAE1 mutant that is retained in the Golgi (G701D) and another kAE1 mutant (C479W) located in the endoplasmic reticulum of kidney cells, and is thus probably unable to reabsorb bicarbonate into the blood. We conclude that the C479W mutant is a novel trafficking...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... The Authors Journal compilation © 2010 Biochemical Society 2010 endoplasmic reticulum oxidoreductase protein disulfide isomerase (PDI) thioredoxin thioredoxin-like transmembrane protein 4 (TMX4) trafficking The relatively oxidizing conditions inside the lumen of the ER (endoplasmic...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... mutant failed to co-localize with Rab11 and recycle to the plasma membrane, in contrast with the wild-type receptor. To our knowledge, the present study is the first report of a direct interaction between the β2AR and a Rab GTPase, which is required for the accurate intracellular trafficking...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 414 (3): 431–440.
Published: 27 August 2008
... 12 5 2008 14 5 2008 14 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 dileucine signal lysosome membrane p40 trafficking The vesicular transport of newly synthesized lysosomal membrane proteins from the TGN ( trans -Golgi network...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 469–475.
Published: 28 May 2008
... acid-sensing ion channel (ASIC) N-glycans structure trafficking ASIC1a and ASIC1b derive from the asic1 gene, probably by using alternative promoters; the N-terminal third of the proteins is different, including the intracellular N-terminus, the first transmembrane domain...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 495–506.
Published: 28 May 2008
... is located in membrane rafts and reaches the cell surface through intracellular trafficking. In the present study we prove that GLYT2 constitutively recycles between the cell interior and the plasma membrane by means of a monensin-sensitive trafficking pathway. Also, a regulated trafficking can be triggered...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...Kathryn A. Stern; Trenton L. Place; Nancy L. Lill EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 463–472.
Published: 27 February 2008
... manner in living cells and propose that ACBP may be involved in vesicular trafficking. 1 To whom correspondence should be addressed (email [email protected] ). 25 4 2007 4 10 2007 22 10 2007 22 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 555–562.
Published: 21 December 2007
... GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that stably expresses inducible temperature-sensitive GPI...
Articles
Gina E. Sosinsky, Joell L. Solan, Guido M. Gaietta, Lucy Ngan, Grace J. Lee, Mason R. Mackey, Paul D. Lampe
Journal:
Biochemical Journal
Biochem J (2007) 408 (3): 375–385.
Published: 28 November 2007
... of connexin trafficking and channel gating. It is well-documented that SDS/PAGE of NRK (normal rat kidney) cell lysates reveals at least three connexin43-specific bands (P0, P1 and P2). P1 and P2 are phosphorylated on multiple, unidentified serine residues and are found primarily in gap-junction plaques...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 171–177.
Published: 25 September 2007
... compilation © 2007 Biochemical Society 2007 furin MT1-MMP (membrane-type 1 matrix metalloproteinase) α1-PI (α1-proteinase inhibitor) trafficking MMPs (matrix metalloproteinases) are a family of zinc-dependent metalloendopeptidases that process a variety of substrates, including proMMP...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 406 (1): 157–165.
Published: 26 July 2007
... components, some gaps are found that cannot be explained in a working model for vesicle trafficking regulation. One of these void spaces is the production of DAG, which is not only necessary to activate PKC, but also to recruit PKD to Golgi membranes in order to be activated and generate vesicle fission...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 525–534.
Published: 29 May 2007
... the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and α-SNAP (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I...
Includes: Supplementary data
Articles
Sonia Fernández-Veledo, Isabel Huber-Ruano, Ivette Aymerich, Sylvie Duflot, F. Javier Casado, Marçal Pastor-Anglada
Journal:
Biochemical Journal
Biochem J (2006) 395 (2): 337–344.
Published: 28 March 2006
... protein may play additional roles other than nucleoside salvage, since it has recently been shown to be under purinergic control via K ATP channels, by a mechanism that does not seem to involve changes in its subcellular localization. In an attempt to identify the agents that promote CNT2 trafficking...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (3): 475–483.
Published: 06 December 2005
... trafficking In eukaryotic cells, mRNA localization to different regions in the cytoplasm provides a mechanism for synthesis of proteins close to where they are required [ 1 – 3 ]. For example, in fibroblasts some mRNAs, such as those encoding β-actin and creatine kinase isoform M, are transported...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (1): 355–362.
Published: 10 May 2005
..., Watanabe, Gomez and Thornhill (2003) J. Biol. Chem. 278 , 25558–25567; Zhu, Watanabe, Gomez and Thornhill (2003) Biochem. J. 375 , 761–768]. In the present study, we focused on the deep pore region of Kv1 members to test whether a cell-surface trafficking code was dictated by two amino acids. Kv1 channels...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 233–241.
Published: 14 December 2004
...Lorena PERRONE; Simona PALADINO; Marialuisa MAZZONE; Lucio NITSCH; Massimo GULISANO; Chiara ZURZOLO The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 380 (3): 805–813.
Published: 15 June 2004
... in close proximity to the canalicular membrane to facilitate biliary copper excretion. In the present study, we investigated the role of the six N-terminal MBSs (metal-binding sites) in the trafficking process. Using site-directed mutagenesis, we mutated or deleted various combinations of the MBSs...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 1031–1037.
Published: 15 March 2004
... in the Golgi compartment and effluxes excess copper from the cell. These roles can be achieved through copper-regulated trafficking of MNK. It has previously been shown to undergo trafficking from the trans -Golgi network to the plasma membrane in response to elevated copper concentrations...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (3): 761–768.
Published: 01 November 2003
...Jing ZHU; Itaru WATANABE; Barbara GOMEZ; William B. THORNHILL Kv1.4 and Kv1.1 potassium channel homomers have been shown to exhibit different intracellular trafficking programmes and cell-surface expression levels in cell lines: a determinant in the pore region of Kv1.4 and Kv1.1 [Zhu, Watanabe...
Articles
Penelope BUXTON, Xiang-Ming ZHANG, Bong WALSH, Absorn SRIRATANA, Irina SCHENBERG, Elizabeth MANICKAM, Tony ROWE
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 433–440.
Published: 15 October 2003
... -ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) synaptosome-associated protein-23 (SNAP23) syntaxin trafficking vesicle Abbreviations used: GST, glutathione S-transferase; SNAP25, synaptosome-associated protein-25; SNAP23, synaptosome-associated protein-23; SNARE, soluble...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 350 (2): 337–352.
Published: 23 August 2000
... reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae . 1 To whom correspondence should be addressed. The Biochemical Society, London © 2000 2000 actin endocytosis exocytosis phosphoinositide trafficking Biochem. J. (2000) 350, 337...
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