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Keywords: transcription factor
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Articles
Biochem J (2020) 477 (19): 3743–3767.
Published: 12 October 2020
... and regeneration strategy to increase desirable genotypes, to develop new genetically modified plants to meet agricultural challenges, and at a basic science level, to test gene function. We briefly review some of the transcription factors (TFs) involved in establishing primary and apical meristems during zygotic...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3131–3145.
Published: 04 September 2020
...; Mert Erkan; Paola A. Romecin-Duran; Alejandro Sarabia Gonzalez; Bo Zhou; Delphine Javelaud; Veronique Marsaud; Rondell P. Graham; Alain Mauviel; Sherine F. Elsawa; Martin E. Fernandez-Zapico The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development and disease...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (15): 2331–2343.
Published: 28 July 2016
.../molecules that control WDR77 gene expression are unknown. Promoter mapping, gel shift assay and ChIP revealed that the WDR77 promoter contains bona fide response elements for E2F and GATA transcriptional factors as demonstrated in prostate cancer, lung cancer and erythroid cells, as well as in mouse lung...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (2): 147–156.
Published: 13 November 2015
... expression microRNA (micro ribonucleic acid) promoter regulation transcription factor type 2 diabetes To construct the let-7 promoter plasmid, we obtained genomic co-ordinates of the let-7 family genes and upstream region information from the University of California, Genome Browser...
Articles
Biochem J (2015) 470 (1): 65–76.
Published: 06 August 2015
..., autophagy, absorption from the cytoplasm and exocytosis. Transcription factor EB (TFEB) regulates lysosomal biogenesis and the expression of lysosomal proteins in response to lysosomal and/or metabolic stresses. Since transition metals cause lysosomal dysfunction, we proposed that TFEB may be activated...
Articles
Biochem J (2013) 449 (3): 751–760.
Published: 09 January 2013
...Pilla Sankara Krishna; Balaga Radha Rani; M. Karthik Mohan; Iwane Suzuki; Sisinthy Shivaji; Jogadhenu S. S. Prakash A conserved hypothetical protein, Sll1130, is a novel transcription factor that regulates the expression of major heat-responsive genes in Synechocystis sp. PCC6803. Synechocystis...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 373–388.
Published: 14 December 2012
...Hong-Feng Zou; Yu-Qin Zhang; Wei Wei; Hao-Wei Chen; Qing-Xin Song; Yun-Feng Liu; Ming-Yu Zhao; Fang Wang; Bao-Cai Zhang; Qing Lin; Wan-Ke Zhang; Biao Ma; Yi-Hua Zhou; Jin-Song Zhang; Shou-Yi Chen Plant-specific DOF (DNA-binding with one finger)-type transcription factors regulate various biological...
Includes: Supplementary data
Articles
Biochem J (2012) 448 (1): 21–33.
Published: 18 October 2012
...Chen Sok Lam; Tapan Kumar Mistri; Yong Hwee Foo; Thankiah Sudhaharan; Hui Theng Gan; David Rodda; Leng Hiong Lim; Chai Chou; Paul Robson; Thorsten Wohland; Sohail Ahmed Oct4 and Sox2 are two essential transcription factors that co-regulate target genes for the maintenance of pluripotency. However...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (1): 125–136.
Published: 12 September 2012
... and reproduction in any medium, provided the original work is properly cited. cytokine interleukin-6 (IL-6) nucleocytoplasmic trafficking signal transducer and activator of transcription 3 (STAT3) transcription factor transcriptome analysis Two distinct STAT3 isoforms originating from alternative...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (1): 89–98.
Published: 27 July 2012
... (electrophoretic mobility-shift analysis) and affinity chromatography, we found that USF1 specifically binds to the E-box sequence (5′-CACGTG-3′), but not to a mutated E-box. CpG methylation of this E-box significantly diminished its binding of transcription factors. Mutation of the E-box within a GATA5 promoter...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (3): 431–439.
Published: 13 July 2012
... known mammalian kinase that is also a ubiquitin ligase. MEKK1 contains a RING domain within its N-terminal regulatory region, and MEKK1 has been shown to ubiquitylate the AP-1 (activator protein 1) transcription factor protein c-Jun, but the mechanism by which MEKK1 interacts with c-Jun to induce...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 395–404.
Published: 29 May 2012
...Ditte H. Welner; Søren Lindemose; J. Günter Grossmann; Niels Erik Møllegaard; Addie N. Olsen; Charlotte Helgstrand; Karen Skriver; Leila Lo Leggio NAC (NAM/ATAF/CUC) plant transcription factors regulate essential processes in development, stress responses and nutrient distribution in important crop...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2012) 443 (1): 39–47.
Published: 14 March 2012
...Ralf Jauch; Calista K. L. Ng; Kamesh Narasimhan; Prasanna R. Kolatkar It has recently been proposed that the sequence preferences of DNA-binding TFs (transcription factors) can be well described by models that include the positional interdependence of the nucleotides of the target sites...
Articles
Biochem J (2012) 443 (1): 153–164.
Published: 14 March 2012
... of hypoxia. In the present study, we located the core proximal promoter of the mouse Ngb gene to a 554 bp segment, which harbours putative conserved NF-κB (nuclear factor κB)- and Egr1 (early growth-response factor 1) -binding sites. Overexpression and knockdown of transcription factors p65, p50, Egr1 or Sp1...
Articles
Biochem J (2012) 442 (3): 573–581.
Published: 24 February 2012
.... In recent years numerous transcription factors controlling various aspects of plant life have been identified. The activity of transcription factors needs to be regulated to prevent unspecific, prolonged or inappropriate responses. The transcription factor DREB2A (DEHYDRATION-RESPONSIVE ELEMENT BINDING 2A...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (2): 167–174.
Published: 14 November 2011
... the ARE (antioxidant-response element), a cis -acting sequence present in the regulatory regions of genes involved in the detoxification and elimination of reactive oxidants and electrophiles. The ARE binds different bZIP (basic-region leucine zipper) transcription factors, most notably Nrf2 (nuclear factor-erythroid...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (1): 157–166.
Published: 27 October 2011
... the basement membrane. Several genes that are up-regulated in breast carcinoma are responsible for mediating the metastatic cascade. Recent studies have revealed that the NFAT (nuclear factor of activated T-cells) is a transcription factor that is highly expressed in aggressive breast cancer cells and tissues...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (3): 523–533.
Published: 26 August 2011
... pH causes rapid nuclear localization of the PKA-regulated Msn2 transcription factor which, together with Msn4, mediates a general stress response by binding with STRE (stress response element) sequences in many promoters. Consequently, a synthetic STRE–LacZ reporter shows a rapid induction...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 253–262.
Published: 13 May 2011
...Jung Ha Kim; Kabsun Kim; Bang Ung Youn; Hye Mi Jin; Ji-Young Kim; Jang Bae Moon; Aeran Ko; Sang-Beom Seo; Kwang-Youl Lee; Nacksung Kim NFATc1 (nuclear factor of activated T-cells c1), a key transcription factor, plays a role in regulating expression of osteoclast-specific downstream target genes...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 313–325.
Published: 29 March 2011
... transporters, involving transcriptional mechanisms and transcription factors that govern their basal regulation or dysregulation in diseased states, has only now started to unfold with the cloning and characterization of their gene promoters. The present review provides a detailed analysis of the core...
Articles
Biochem J (2011) 435 (1): 157–166.
Published: 15 March 2011
... derivative, shows that the protein assumes a swapped-hairpin fold, which is a distinctive fold associated with a family of prokaryotic transcription factors, such as AbrB from Bacillus subtilis . Nevertheless, C68 constitutes a novel representative of this family because it shows several peculiar structural...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (1): 145–153.
Published: 15 December 2010
...Shaheen Mowla; Romaney Pinnock; Virna D. Leaner; Colin R. Goding; Sharon Prince The T-box transcription factor TBX3 provides an important link between embryonic development and cancer. TBX3 mediates limb, mammary gland and heart development and, in humans, mutations resulting in haplo-insufficiency...
Articles
Biochem J (2010) 426 (2): 119–123.
Published: 09 February 2010
... relationship of regulatory factors and suggest that varying them individually, either by deletion from whole genome duplication or by duplication in a CNV, produces a dosage effect that is detrimental. These results support the idea that the subtle global modulations caused by altered transcription factor...
Articles
Biochem J (2010) 425 (1): 41–52.
Published: 14 December 2009
... ). 13 7 2009 14 8 2009 18 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 adiponectin Dsb endoplasmic reticulum stress inflammation insulin peroxisome-proliferator-activated receptor γ (PPARγ) transcription factor Adiponectin, a 30-kDa...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 419 (2): 247–259.
Published: 27 March 2009
... to form networks in which key protein kinases, phosphatases and target transcription factors represent hubs on/from which multiple pathways converge and emerge. 1 To whom correspondence should be addressed (email nigel.halford@bbsrc.ac.uk ). 19 12 2008 30 1 2009 2 2 2009 ©...
Articles
Biochem J (2008) 416 (3): 387–394.
Published: 26 November 2008
...Patrick J. Pollard; Christoph Loenarz; David R. Mole; Michael A. McDonough; Jonathan M. Gleadle; Christopher J. Schofield; Peter J. Ratcliffe The transcription factor HIF (hypoxia-inducible factor) mediates a highly pleiotrophic response to hypoxia. Many recent studies have focused on defining...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (3): 419–429.
Published: 27 August 2008
...Anja Spielvogel; Helen Findon; Herbert N. Arst, Jr; Lidia Araújo-Bazán; Patricia Hernández-Ortíz; Ulf Stahl; Vera Meyer; Eduardo A. Espeso To investigate cation adaptation and homoeostasis in Aspergillus nidulans , two transcription-factor-encoding genes have been characterized. The A. nidulans...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (3): e17–e19.
Published: 28 May 2008
... mechanism underlying these responses is the transcriptional regulation of HIF-1α by the redox-sensitive transcription factor NF-κB (nuclear factor κB), which binds at a distinct element in the proximal promoter of the HIF-1α gene. More recently, NF-κB binding to this site in the HIF-1α promoter has been...
Articles
Biochem J (2008) 412 (1): 153–162.
Published: 25 April 2008
...] in HBEpCs (human bronchial epithelial primary cells). The present study provides evidence that LPA-induced transactivation of EGFR regulates COX (cyclo-oxygenase)-2 expression and PGE 2 [PG (prostaglandin) E 2 ] release through the transcriptional factor, C/EBPβ (CCAAT/enhancer-binding protein β), in HBEpCs...
Articles
Biochem J (2008) 411 (2): 261–270.
Published: 27 March 2008
.../leucine zipper transcription factor that regulates expression of these genes. To evaluate the potential role of ChREBP phosphorylation in its regulation, we used MS to identify modified residues. In the present paper, we report the detection of multiple phosphorylation sites of ChREBP expressed...
Includes: Supplementary data
Articles
Biochem J (2008) 409 (1): 179–185.
Published: 11 December 2007
.... Kushner S. A. Chung C. D. Chang D. D. Shuai K. Inhibition of Stat1-mediated gene activation by PIAS1 Proc. Natl. Acad. Sci. U.S.A. 1998 95 10626 10631 13 Kotaja N. Karvonen U. Janne O. A. Palvimo J. J. PIAS proteins modulate transcription factors...
Articles
Biochem J (2007) 404 (1): e1.
Published: 26 April 2007
...Haydeé L. Ramos; John J. O'Shea; Wendy T. Watford STAT (signal transducer and activator of transcription) family transcription factors are critical regulators of the development and differentiation of many cell types. STAT isoforms are generated by alternative splicing, but have also been suggested...
Articles
Biochem J (2007) 403 (3): e13–e14.
Published: 12 April 2007
... genus Nicotiana : the conversion of a nuclear transcription factor into the plastid-resident protein WIN4 (wound-induced clone 4) involved in environmental stress responses. In this issue of the Biochemical Journal , Kodama and Sano now show that two steps are necessary for the establishment...
Articles
Biochem J (2006) 400 (2): 367–375.
Published: 14 November 2006
... revealed two conserved putative binding sites for transcription factor(s) regulated by NO and/or changes in intracellular iron level: Sp1 (promoter-selective transcription factor 1) and MTF1 (metal transcription factor 1), plus GAS (interferon-γ-activated sequence), a binding site for STAT (signal...
Articles
Biochem J (2006) 400 (2): 327–335.
Published: 14 November 2006
... and showed that it also has bidirectional promoter activity in both neuronal and muscle cells as evidenced by luciferase reporter assay studies. Alignment of the human, mouse, rat, rabbit and dog promoters reveals several highly conserved transcription factor-binding sites. Gel electrophoretic mobility-shift...
Articles
Biochem J (2006) 397 (2): 233–246.
Published: 28 June 2006
...Patrick J. E. C. Wijchers; J. Peter H. Burbach; Marten P. Smidt Forkhead proteins comprise a highly conserved family of transcription factors, named after the original forkhead gene in Drosophila . To date, over 100 forkhead genes have been identified in a large variety of species, all sharing...
Articles
Biochem J (2006) 396 (2): 371–380.
Published: 15 May 2006
... and activator of transcription 1 (STAT1) Tat transcription factor The complex pathogenesis of AIDS and related syndromes involves factors that are able to also act on non-infected cells, and one such a factor is Tat. The HIV-1 transactivator protein Tat is a ∼14/15 kDa protein produced early after...
Articles
Biochem J (2006) 396 (1): 163–172.
Published: 26 April 2006
... expression, and C/EBPβ (CCAAT/enhancer-binding protein β), as the two transcription factors the binding sites of which were most enriched in the promoters of p38α-regulated genes. We have focused on the study of the extracellular matrix component COL1A1 (α1 chain of type I collagen) and found evidence...
Includes: Supplementary data
Articles
Biochem J (2006) 394 (1): 27–33.
Published: 27 January 2006
... Society, London 2006 calcium E twenty-six-1 (Ets-1) histamine sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 3 (SERCA 3) specificity protein 1 (Sp1) transcription factor The SERCA (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase) is encoded by three different genes ATP2a1 , ATP2a2...
Articles
Biochem J (2006) 393 (1): 255–265.
Published: 12 December 2005
.... Within this 106 bp fragment, there is a potential binding motif for the transcription factor Oct-1 (octamer-1). By electrophoretic mobility-shift assay, we observed the activation of Oct-1 by ox-LDL. The critical role of Oct-1 in ox-LDL-induced LOX-1 promoter activation was further confirmed...
Articles
Biochem J (2005) 392 (1): 1–11.
Published: 08 November 2005
... transcription factors has been identified and characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes. Specific activation...
Articles
Biochem J (2005) 391 (3): 613–621.
Published: 25 October 2005
.... These transcription factors were purified by DNA affinity, analysed by MS and identified as p54 nrb /NonO (nuclear RNA binding protein) and PSF (protein-associated splicing factor). The PiC silencer region cloned in front of the ferritin promoter conferred a strong inhibition to the heterologous promoter...
Articles
Biochem J (2005) 388 (3): 913–920.
Published: 07 June 2005
.... In addition, p65 overexpression enhanced, whereas p50 overexpression decreased, the luciferase activity. Furthermore, mutation of the NF-κB DNA binding site blocked this p65- and tumour necrosis factor-α-induced luciferase activity. These findings suggest that the transcription factor NF-κB plays an important...
Articles
Biochem J (2005) 387 (3): 737–745.
Published: 26 April 2005
... and that Sp3 (specificity protein 3), a ubiquitously expressed transcription factor, but not Sp1 binds to this GC-rich motif, suggesting that Sp3 is involved in the regulation of SOCS3 expression. The results suggest that Sp3 is important for IL-6-induced transcriptional activation of the SOCS3 (gene) promoter...
Articles
Biochem J (2005) 386 (1): 63–72.
Published: 08 February 2005
... transcription start site which is capable of preferentially driving the expression of a reporter gene in human neuronal cell lines. This region contains the cognate DNA sites for the transcription factors Sp1/3/4 (transcription factors 1/3/4 purified from S ephacryl and p hosphocellulose columns), NF-Y (nuclear...
Includes: Supplementary data
Articles
Biochem J (2004) 384 (1): 169–178.
Published: 09 November 2004
... into two compartments: a larger mother cell and a smaller prespore. Differential gene expression is established in these two compartments through the activation of a series of cell-type-specific transcription factors, known as sigma factors. The earliest sigma factor to be activated is the prespore...
Includes: Supplementary data
Articles
Biochem J (2004) 383 (2): 383–391.
Published: 08 October 2004
...Tapan K. BISWAS; Godfrey S. GETZ Mitochondrial (mt) translocation of the nuclearly encoded mt transcription factor Mtf1p appears to occur independent of a cleavable presequence, mt receptor, mt membrane potential or ATP [Biswas and Getz (2002) J. Biol. Chem. 277 , 45704–45714]. To understand...
Articles
Biochem J (2004) 383 (1): 179–185.
Published: 24 September 2004
... sequence analysis of the region located upstream of the alternative exon revealed some potential DNA-binding sites, one of which is specific to the binding of CREM (cAMP-response element modulator) transcription factors. By using electrophoretic mobility-shift assays, we demonstrated that both nuclear...
Articles
Biochem J (2004) 382 (1): 177–182.
Published: 10 August 2004
... osmolyte osmoregulation promoter assay taurine transporter tonicity-responsive element-binding protein (TonEBP) transcription factor Taurine is one of the most abundant free amino acids in mammalian tissues. Taurine contributes to many physiological functions, such as modulation of ion...
Articles
Biochem J (2004) 381 (3): e3.
Published: 27 July 2004
... domains that participate in intermolecular interactions. A study by Matt et al. in this issue of the Biochemical Journal has examined the transcription factor binding properties of the zinc-binding module C/H1 (cysteine/histidine-rich region 1) found in the transcriptional co-activator proteins CBP (CREB...