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Keywords: transcription factors
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Articles
Biochem J (2019) 476 (19): 2757–2767.
Published: 11 October 2019
...Sowmya P. Lakshmi; Aravind T. Reddy; Asoka Banno; Raju C. Reddy Nur77 is a transcription factor belonging to the NR4A subfamily of nuclear hormone receptors. Upon induction, Nur77 modulates the expression of its target genes and controls a variety of biological and pathophysiological processes...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2018) 475 (7): 1323–1334.
Published: 16 April 2018
... whether the low CFTR levels in the airway epithelium result from the recruitment of repressive proteins directly to the locus. Using an siRNA screen to deplete ∼1500 transcription factors (TFs) and associated regulatory proteins in Calu-3 lung epithelial cells, we identified nearly 40 factors that upon...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (2): 441–454.
Published: 31 January 2018
... and spacing, enabling efficient gas exchange. The cellular patterning process is regulated by a complex signalling pathway involving extracellular ligand–receptor interactions, which, in turn, modulate the activity of three master transcription factors essential for the formation of stomata. Here, we...
Articles
Biochem J (2017) 474 (24): 4091–4104.
Published: 06 December 2017
...Natália E. Bernardes; Agnes A.S. Takeda; Thiago R. Dreyer; Fernanda B. Cupertino; Stela Virgilio; Nelly Pante; Maria Célia Bertolini; Marcos R.M. Fontes The Neurospora crassa NIT-2 transcription factor belongs to the GATA transcription factor family and plays a fundamental role in the regulation of...
Articles
Biochem J (2017) 474 (15): 2509–2532.
Published: 12 July 2017
...Lasse Staby; Charlotte O'Shea; Martin Willemoës; Frederik Theisen; Birthe B. Kragelund; Karen Skriver Gene-specific transcription factors (TFs) are key regulatory components of signaling pathways, controlling, for example, cell growth, development, and stress responses. Their biological functions...
Articles
Biochem J (2017) 474 (9): 1509–1528.
Published: 19 April 2017
...–protein interactions proteolysis transcription factors The fusion proteins were induced in Escherichia coli by the addition of 1 mM isopropyl-1-thio-β- d -galactopyranoside for up to 4 h. After lysis and sonication in IP buffer containing protease and phosphatase inhibitors, GST or GST fusion...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (13): 1967–1976.
Published: 28 June 2016
... aimed at identifying DNA elements and transcription factors involved in Dp71 expression in hepatic cells. Relevant DNA elements on the Dp71 promoter were identified by comparing Dp71 5′-end flanking regions between species. The functionality of these elements was demonstrated by site-directed...
Articles
Biochem J (2005) 392 (1): 181–189.
Published: 08 November 2005
...Wataru Nishimura; Therese Salameh; Takuma Kondo; Arun Sharma The transcription factor MafA/RIPE3b1 is an important regulator of insulin gene expression. MafA binds to the insulin enhancer element RIPE3b (C1-A2), now designated as insulin MARE (Maf response element). The insulin MARE element shares...
Articles
Biochem J (2003) 372 (3): 831–839.
Published: 15 June 2003
...Elisabetta LAMBERTINI; Letizia PENOLAZZI; Silvia GIORDANO; Laura DEL SENNO; Roberta PIVA (O)estrogen receptor-α (ERα), a hormone-dependent transcription factor belonging to the steroid/thyroid-hormone-receptor superfamily, plays an essential role in the development and maintenance of the skeleton...
Articles
Biochem J (2002) 365 (3): 561–575.
Published: 01 August 2002
...Dipak P. RAMJI; Pelagia FOKA CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. At least six members of the family have been isolated and...
Articles
Biochem J (2002) 363 (1): 53–58.
Published: 22 March 2002
... promoters without binding directly to the target DNA. 1 To whom correspondence should be addressed (e-mail fsc@unicz.it ). 11 7 2001 5 12 2001 29 1 2002 The Biochemical Society, London ©2002 2002 CBP/p300 nuclear factor Y transcription factors Abbreviations used...
Articles
Biochem J (2002) 363 (1): 195–200.
Published: 22 March 2002
... microtubule-associated colonic and hepatic tumour overexpressed (ch-TOG) protein, and the oncogenic transcription factor glioma amplified sequence 41/NuMA binding protein 1 (GAS41/NuBI1; where NuMA stands for nuclear mitotic apparatus protein 1). This suggests that the TACC proteins can form multiple...
Articles
Biochem J (2001) 360 (2): 321–333.
Published: 26 November 2001
...Claire JOSSE; Johan R. BOELAERT; Martin BEST-BELPOMME; Jacques PIETTE The transcription factor, nuclear factor κB (NF-κB), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H 2 O 2 gives rise to NF-κB nuclear...
Articles
Biochem J (2001) 360 (2): 285–294.
Published: 26 November 2001
...Eliana M. COCCIA; Emilia STELLACCI; Mauro VALTIERI; Barbara MASELLA; Tiziana FECCIA; Giovanna MARZIALI; John HISCOTT; Ugo TESTA; Cesare PESCHLE; Angela BATTISTINI Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act as their...
Articles
Biochem J (2001) 356 (2): 571–579.
Published: 24 May 2001
... transcription factors, such as upstream stimulatory factor or activator protein 4. The discovery of a downstream element crucial for annexin A5 gene transcription, and its interaction with a potentially novel transcription factor or complex, may provide a clue to understanding the initiation of transcription by...
Articles
Biochem J (2000) 346 (2): 529–535.
Published: 22 February 2000
... transgenic mice that the tissue-specific and developmental expression of lactase is controlled by a 1 kb upstream region of the pig lactase gene. Two homeodomain transcription factors, caudal-related homeodomain protein (Cdx2) and hepatic nuclear factor 1α (HNF1α), are known to bind to regulatory cis...
Articles
Biochem J (1999) 343 (3): 687–695.
Published: 25 October 1999
... correspondence should be addressed ( Martine.Aggerbeck@biomedicale.univ-paris5.fr ). The Biochemical Society, London © 1999 1999 glucocorticoids forkhead proteins transcription factors gene regulation Biochem. J. (1999) 343, 687 695 (Printed in Great Britain) 687 Delineation of the insulin...
Articles
Biochem J (1999) 341 (2): 315–322.
Published: 08 July 1999
... transcription factors Biochem. J. (1999) 341, 315 322 (Printed in Great Britain) 315 Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic b-cells Jin QIAN*, Elizabeth N. KAYTOR‹1, Howard C. TOWLE‹ and L. Karl OLSON*2 *Department of Physiology, Michigan State University...
Articles
Biochem J (1999) 339 (1): 135–141.
Published: 25 March 1999
...Timothy W. FAWCETT; Jennifer L. MARTINDALE; Kathryn Z. GUYTON; Tsonwin HAI; Nikki J. HOLBROOK Gadd153 , also known as chop , encodes a member of the CCAAT/enhancer-binding protein (C/EBP) transcription factor family and is transcriptionally activated by cellular stress signals. We recently...
Articles
Biochem J (1999) 339 (1): 167–175.
Published: 25 March 1999
... To whom correspondence should be addressed (e-mail cornelia.mauch@uni-koeln.de ). 12 8 1998 8 12 1998 20 1 1999 The Biochemical Society, London © 1999 1999 ERK c-Fos JNK c-Jun signal transduction transcription factors Biochem. J. (1999) 339, 167 175 (Printed in...
Articles
Biochem J (1999) 338 (3): 607–613.
Published: 08 March 1999
... Paris, France (e-mail Mojgan.Mergny@curie.fr ). oxidative stress skin transcription factors UV radiation 17 9 1998 3 12 1998 22 12 1998 The Biochemical Society, London © 1999 1999 Biochem. J. (1999) 338, 607 613 (Printed in Great Britain) 607 UV-A-induced decrease in...
Articles
Biochem J (1999) 338 (1): 91–97.
Published: 08 February 1999
...Roger H. ERICKSON; James R. GUM; Craig D. LOTTERMAN; James W. HICKS; Roy S. LAI; Young S. KIM Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the...