...Meiru Si; Can Chen; Zengfan Wei; Zhijin Gong; GuiZhi Li; Shumin Yao MarR (multiple antibiotic resistance regulator) proteins are a family of transcriptional regulators that is prevalent in Corynebacterium glutamicum . Understanding the physiological and biochemical function of MarR homologs in C...

...Meiru Si; Can Chen; Tao Su; Chengchuan Che; Shumin Yao; Guangjie Liang; Guizhi Li; Ge Yang The MarR family is unique to both bacteria and archaea. The members of this family, one of the most prevalent families of transcriptional regulators in bacteria, enable bacteria to adapt to changing...

... interactions protein–protein interactions small-angle scattering transcription regulation To ensure the correct partitioning of chromosomes before cell division, most bacteria use a type Ia partitioning system consisting of a DNA-binding protein from the ParB family; a filament-forming ATPase from...

... development. AP2 binds to the human Frizzled 1 (FZD1) promoter and down-regulates FZD1 expression in osteoblasts. In addition, AP2 negatively regulates osteoblast differentiation and mineralization in part through down-regulation of FZD1 expression. AP2 FZD1 osteoblast transcription regulation Wnt...

... be extended to its phospholipid synthesis activator capacity, which means that new mechanisms of transcriptional regulation can be envisaged. activator protein-1 (AP-1) transcription factor c-Fos-dependent phospholipid synthesis nuclear phospholipid synthesis phosphatidylinositol-4 5-bisphosphate...

... to peak at the time of initiation, and the rate at which the amount of DnaA–ATP increases during the cell cycle can affect the timing of initiation [ 1 , 14 ]. cell cycle DNA replication Escherichia coli temperature adaptation transcription regulation © The Authors Journal compilation ©...

... initiation transcription regulation transcription start site Cell development, function and survival under stress depend on gene-specific activation and repression. A fundamental question in the life sciences is how does nature accomplish this task? A crucial step is binding of TFs (transcription...

... factor-erythroid 2-related factor 2 (Nrf2) oxidative stress transcription regulation The transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) is activated by electrophiles and oxidative stress. Consequently, it co-ordinately regulates a battery of genes that encode...

... The Authors Journal compilation © 2011 Biochemical Society 2011 C-terminal domain RNA polymerase II transcription regulation transcription termination tyrosine phosphatase The CTD (C-terminal domain) of RNA polymerase II in eukaryotes orchestrates the temporal and spatial control...

... 3 2009 15 6 2009 26 6 2009 26 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Ccr4–Not complex gene expression mRNA deadenylation proteomics transcription regulation The evolutionarily conserved Ccr4–Not complex is important...

... Society 2009 arginine methylation enzyme activity histone protein arginine methyltransferase (PRMT) small-molecule inhibitor transcription regulation Arginine methylation is a widespread post-translational modification in eukaryotes and its significance in regulating many cellular...

... chemical insults. On the other hand, the far and distal modules differ markedly in responding to HNF-4α, suggesting that both modules are engaged in a fine-tuning co-ordination in the transcription regulation of the CYP3A4 gene. We thank Dr Todd Leff and Dr Ronald M. Evans for providing constructs...

... 2006 14 9 2006 21 9 2006 21 9 2006 The Biochemical Society, London 2007 amino acid response element (AARE) amino acid-sensing activating transcription factor 3 (ATF3) CCAAT/enhancer-binding protein (C/EBP) histone acetylation transcription regulation...

... proteins. We observed physical interactions of CNOT2 with several subunits of the SMRT/NCoR–HDAC3 complex. Our results show that the SMRT/NCoR–HDAC3 complex is a cofactor of CNOT2-mediated repression and suggest that transcriptional regulation by the Ccr4–Not complex involves regulation of chromatin...

... heterogeneous nuclear ribonucleoprotein K osteoblast osteocalcin transcription regulation EMSAs were performed as described previously, with minor modification [ 10 ]. Briefly, nuclear extracts were prepared according to the methods of Dignam et al. [ 23 ] with the addition of 1 mg/ml leupeptin, 1 mg/ml...

... longevity and long-range efficiency to the antitermination complexes [ 10 – 12 ]. A closely related antitermination system underlies the transcriptional regulation of rRNA ( rrn ) operons [ 13 – 18 ]. The λN antitermination complexes rely on intricate protein–protein and protein–RNA networks dominated...

..., U.S.A.). differential splicing 3-hydroxy-3-methylglutaryl-CoA reductase mandibular organ methyl farnesoate phosphorylation transcription regulation Mevalonic acid is the central substrate for the production of isoprenoids. A key enzyme in its synthesis is 3-hydroxy-3-methylglutaryl...

... 11 2002 6 11 2002 The Biochemical Society, London ©2003 2003 AP-2 binding site ERBB2 promoter HER2 transcription factor HTF human transcription regulation Abbreviations used: AP-2, activator protein-2; EGF, epidermal growth factor; EMSA, electrophoretic mobility...

...Fátima-Zahra IDRISSI; Benjamin PIÑA The yeast transcriptional regulator Rap1p binds to the DNA consensus sequence ACACCCAYACAYYY. We have previously shown that DNA-binding sites in which all four Y (Y = T or C) positions were Ts (UASrpg sequences) synergized more efficiently to activate...

... a fundamental role for positive and negative cis-acting DNA elements in regulating the basal and cAMP-induced transcription activity of the mouse UCP2 gene. Key words: enhancer, promoter analysis, reporter assay, silencer, transcription regulation. via the sympathetic nervous system [12], and noradrenaline...

... ). 24 9 1998 30 11 1998 11 1 1999 The Biochemical Society, London © 1999 1999 footprinting gene expression IGF-II promoter-binding proteins transcription regulation Biochem. J. (1999) 338, 799 806 (Printed in Great Britain) 799 Dual role for transcription factor AP-2...