... ubiquitination Notch1 NUMB transcriptional activation During normal development and homoeostasis the Notch receptor is an important regulator of cellular differentiation, proliferation and apoptotic events, and directs the cell fate selection of cells [ 1 , 2 ]. There are four mammalian Notch...

...) fatty acid synthase (FAS) direct repeat-1 (DR-1) carbohydrate response element-binding protein (ChREBP) primary hepatocyte transcriptional activation Consumption of a high-carbohydrate diet activates transcription of genes involved in glycolysis and de novo fatty acid synthesis...

...) tert-butylhydroquinone thioredoxin transcriptional activation All transient transfections were carried out using Lipofectamine™ 2000 (Invitrogen, Melbourne, Australia) according to the manufacturer's instructions. After a 6 h incubation at 37 °C, 100 μM tBHQ was applied to all MDA-MB-231 cells...

... on transcriptional activity). The transcription reactions were terminated by the addition of 0.2% (w/v) SDS, 10 mM EDTA and 100 μg/ml glycogen and were analysed by electrophoresis on 7 M urea/8% polyacrylamide gels. The stability of the interaction between TFIIIB and the tRNA 1 Gly - 4 gene...

... to activate transcription including SMAD 8. Our results suggest that BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene. 1 To whom correspondence should be addressed, at Universidade Federal do Rio de Janeiro, Av Brigadeiro Trompowsky s/n, Centro de...

... was subjected to deletional analysis to detect any regulatory element in addition to the two known chondrocyte-specific enhancer elements B/C and D/E. Deletion of the region from −342 to −242 bp reduced transcriptional activity to less than 50% of wild-type, but the sequence showed no independent ability...

...Elena KISTANOVA; Helen DELL; Panayota TSANTILI; Eileen FALVEY; Christos CLADARAS; Margarita HADZOPOULOU-CLADARAS The hepatocyte nuclear factor-4 (HNF-4) contains two transcription activation domains. One domain, activation function-1 (AF-1), consists of the extreme N-terminal 24 amino acids...

...Cristiana E. JUGE-AUBRY; Stéphane KUENZLI; Jean-Charles SANCHEZ; Denis HOCHSTRASSER; Christoph A. MEIER The transcriptional activity of peroxisome proliferator-activated receptors (PPARs), and of nuclear hormone receptors in general, is subject to modulation by cofactors. However, most currently...

... high levels of IL-6 in response to tumour necrosis factor-α (TNF-α) and IL-1β, the HTM-29 cell line failed to produce both IL-6 protein and mRNA. Nevertheless, the transcription factors nuclear factor-κB (NF-κB) and NF-IL6, the main factors involved in IL-6 gene transcriptional activation by cytokines...

...Xiuguang MA; Dong YUAN; Tom SCARBOROUGH; Jun MA Bicoid is a Drosophila morphogenetic protein required for the development of anterior structures in the embryo. To gain a better understanding of how Bicoid works as a transcriptional activator, we systematically analysed various functions of Bicoid...