... a role in co-ordinating transcriptional responses to hypoxia [ 18 ], these include NF-κB [ 19 ], REST [ 20 ], p53 [ 21 ] and MYC [ 22 ]. While initial investigation into gene expression changes in hypoxia was limited to individual or small groups of genes, high throughput transcriptomic profiling...

... metabolomics optimisation proteomics transcriptomics Much of microbial biotechnology consists conceptually of two main optimisation problems [ 1 ]: (i) deciding which proteins whose levels should be changed, and (ii) by which amounts. The former is ostensibly somewhat simpler, e.g. when a specific...

... neurotoxicity remain undefined. Understanding these processes will underpin therapeutic and control strategies for human and animal prion diseases, respectively. Prion diseases are difficult to study in their natural hosts and require the use of tractable animal models. Here we used RNA-Seq-based transcriptome...

... BY) . globotriaosylsphingosine lysosomal enzyme proteasome inhibitor protein misfolding transcriptomics New therapeutic approaches include the use of small molecules, which have the capacity to modify proteostasis, including protein synthesis, folding and degradation. They either increase the folding capacity of the ER...

... 12 2019 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 apoptosis autophagy breast cancers DNA synthesis and repair lysosomes transcriptomics Breast cancer is a leading cause of death among women. Notably, five-year...

...Emre Amirak; Stephen J. Fuller; Peter H. Sugden; Angela Clerk ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2...