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Keywords: transferrin
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Articles
Biochem J (2016) 473 (10): 1315–1327.
Published: 11 May 2016
... mechanism of this perturbation, we measured the effects of Rab14 knockdown on the trafficking kinetics of Glut4 relative to two proteins that partially co-localize with Glut4, the transferrin (Tf) receptor and low-density-lipoprotein-receptor-related protein 1 (LRP1). Our data support the hypothesis that...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (3): e7–e9.
Published: 10 October 2014
...Giada Sebastiani; Kostas Pantopoulos Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently...
Articles
Biochem J (2014) 462 (1): e1–e3.
Published: 24 July 2014
... acquisition: Tf (transferrin)-bound and non-Tf-bound Fe uptake. First, under physiological conditions, virtually all Fe in plasma is tightly bound to the major plasma Fe-binding protein, Tf [ 1 , 2 ]. Holo-Tf (Fe–Tf) binds to the integral membrane protein, TfR1 (Tf receptor 1), to donate Fe to cells [ 2...
Articles
Biochem J (2014) 461 (1): 33–42.
Published: 13 June 2014
... with protein amino groups, known as glycation, has been shown to compromise the action of Tf (transferrin), the systemic iron transporter. In order to understand the structural alterations that impair its function, Tf was glycated in vitro and the modification sites were determined by MS. Iron binding...
Articles
Biochem J (2013) 449 (1): 275–284.
Published: 07 December 2012
... an unbiased proteomics screen where we identified TfR1 (transferrin receptor 1). TfR1 is required for transferrin binding and internalization and ultimately for iron homoeostasis. TfR1 depletion does not lead to changes in IKK subunit protein levels; however, it does reduce the formation of the IKK...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (2): 189–197.
Published: 11 May 2012
...Leslie P. Silva; Rong-hua Yu; Charles Calmettes; Xue Yang; Trevor F. Moraes; David C. Schriemer; Anthony B. Schryvers The ability to acquire iron directly from host Tf (transferrin) is an adaptation common to important bacterial pathogens belonging to the Pasteurellaceae, Moraxellaceae and...
Articles
Biochem J (2010) 429 (1): 185–193.
Published: 14 June 2010
...Maya Shvartsman; Eitan Fibach; Z. Ioav Cabantchik In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real-time fluorimetry and flow cytometry, in conjunction with...
Articles
Biochem J (2009) 417 (3): 685–694.
Published: 16 January 2009
... virulence of a pleomorphic strain of the parasite, for reasons that are not clear. In the present paper, we report that GPI-PLC stimulates endocytosis of transferrin by 300–500%. Surprisingly, GPI-PLC is not detected at endosomes, suggesting that the enzyme does not interact directly with the endosomal...
Articles
Biochem J (2008) 409 (2): 439–447.
Published: 21 December 2007
... transferrin. Again, the simultaneous presence of both a bidentate chelator and DFO was found to enhance the rate of iron chelation from transferrin at clinically relevant chelator levels. Deferiprone was found to be particularly effective at ‘shuttling’ iron from transferrin to DFO, probably as a result of...
Articles
Biochem J (2007) 404 (2): 217–225.
Published: 14 May 2007
...Ali G. Khan; Stephen R. Shouldice; Shane D. Kirby; Rong-hua Yu; Leslie W. Tari; Anthony B. Schryvers The periplasmic iron-binding protein, FbpA (ferric-ion-binding protein A), performs an essential role in iron acquisition from transferrin in Haemophilus influenzae . A series of site-directed...
Articles
Biochem J (2007) 403 (1): 43–48.
Published: 13 March 2007
...Ali G. Khan; Stephen R. Shouldice; Leslie W. Tari; Anthony B. Schryvers The acquisition of iron from transferrin by Gram-negative bacterial pathogens is dependent on a periplasmic ferric-ion-binding protein, FbpA. FbpA shuttles iron from the outer membrane to an inner membrane transport complex. A...
Articles
Biochem J (2006) 400 (2): 267–280.
Published: 14 November 2006
...Daniel Wüstner Transport of the recycling marker transferrin was analysed in polarized hepatic HepG2 cells using quantitative fluorescence microscopy and mathematical modelling. A detailed map and kinetic model for transport of transferrin in hepatic cells was developed. Fluorescent transferrin was...
Includes: Supplementary data
Articles
Biochem J (2005) 390 (1): 273–283.
Published: 09 August 2005
...) transferrin In mammalian cells cholesterol homoeostasis is achieved through complex regulatory circuits that control, on the one hand, the biosynthesis and esterification of cholesterol and, on the other, the uptake of cholesterol from lipoprotein carriers and the efflux of cholesterol to...
Articles
Biochem J (2004) 381 (3): 629–634.
Published: 27 July 2004
...Alessia CALZOLARI; Silvia DEAGLIO; Nadia Maria SPOSI; Eleonora PETRUCCI; Ornella MORSILLI; Marco GABBIANELLI; Fabio MALAVASI; Cesare PESCHLE; Ugo TESTA Human TFR2 (transferrin receptor 2) is a membrane-bound protein homologous with TFR1. High levels of TFR2 mRNA were found mainly in the liver and...
Articles
Biochem J (2002) 365 (1): 127–132.
Published: 01 July 2002
... mice, following phagocytosis of 59 Fe-labelled transferrin—anti-transferrin immune complexes, showed reduced iron release compared with cells from wild-type iNOS littermates. Uptake of the complexes by macrophages was similar in iNOS-deficient and wild-type mice. Ferritin was up-regulated by IFNγ/LPS...
Articles
Biochem J (2001) 359 (2): 249–254.
Published: 08 October 2001
...Philippa MILLS; Kevin MILLS; Peter CLAYTON; Andrew JOHNSON; David WHITEHOUSE; Bryan WINCHESTER The N-linked glycans on transferrin and α 1 -antitrypsin from patients with congenital disorders of glycosylation type I have increased fucosylation and branching relative to normal controls. The elevated...
Articles
Biochem J (2001) 357 (3): 881–886.
Published: 25 July 2001
...James MWANJEWE; Betsy King HUI; Michael D. COUGHLIN; Ashok K. GROVER Phaeochromocytoma PC12 cells treated with nerve growth factor (NGF) differentiate into a neuronal phenotype. Here we compare the uptake of transferrin-bound and non-transferrin-bound iron in NGF-treated (neuronal phenotype) and...