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Keywords: transferrin receptor
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Biochem J (2007) 406 (1): 1–12.
Published: 26 July 2007
... oncogenesis phosphoinositide 3-kinase (PI3K) transferrin receptor In 1972, Robert W. Holley, Nobel Laureate for his work demonstrating that tRNA interprets the genetic code, published a short “Unifying hypothesis concerning the nature of malignant growth” [ 1 ]. In this article, he suggested...
Biochem J (2006) 395 (3): 501–507.
Published: 11 April 2006
....), concurrent with a 4.5±2.1-fold (mean±S.D.) increase in transferrin receptor, indicating that overexpression of FerH is sufficient to elicit a phenotype of iron depletion. These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall...
Biochem J (2005) 388 (1): 143–150.
Published: 10 May 2005
... ferritin iron metabolism iron regulatory protein iron-responsive element transferrin receptor Iron is essential for a number of cellular functions, but when present in excess, it catalyses the generation of reactive oxygen species, and leads to tissue damage [ 1 ]. Consequently, iron metabolism...
Biochem J (2004) 381 (3): 629–634.
Published: 27 July 2004
...Alessia CALZOLARI; Silvia DEAGLIO; Nadia Maria SPOSI; Eleonora PETRUCCI; Ornella MORSILLI; Marco GABBIANELLI; Fabio MALAVASI; Cesare PESCHLE; Ugo TESTA Human TFR2 (transferrin receptor 2) is a membrane-bound protein homologous with TFR1. High levels of TFR2 mRNA were found mainly in the liver...
Biochem J (2004) 377 (1): 61–67.
Published: 01 January 2004
... liposomes. A biotinylated poly(ethylene glycol) (PEG)-phospholipid [bio-PEG-distearoylphosphatidylethanolamine (DSPE)] was used as a linker between a streptavidin-conjugated monoclonal antibody (mAb) (i.e. the OX26 mAb raised against the rat transferrin receptor) and 150 nm liposomes. OX26–streptavidin had...
Biochem J (2003) 373 (1): 145–153.
Published: 01 July 2003
...Paige S. DAVIES; An-Sheng ZHANG; Emily L. ANDERSON; Cindy N. ROY; Michael A. LAMPSON; Timothy E. McGRAW; Caroline A. ENNS HFE, the protein mutated in hereditary haemochromatosis type 1, is known to interact with the transferrin receptor (TfR) on the cell surface and during endocytosis [Gross...
Biochem J (2003) 370 (3): 891–899.
Published: 15 March 2003
..., manifested in the activation of iron-regulatory protein and concomitant increase in transferrin receptor levels and decrease in ferritin content. This phenotype persists in cells expressing wild-type HFE after transfection with a β 2 M cDNA. Whereas endogenous β 2 M is sufficient for the presentation...
Biochem J (2001) 356 (3): 883–889.
Published: 08 June 2001
... iron transfer. Transferrin receptor expression was increased at both mRNA and protein levels. Similarly, expression of the iron-responsive element (IRE)-regulated form of the divalent metal transporter 1 (DMT1) was also increased. In contrast, the non-IRE regulated isoform showed no change in mRNA...
Biochem J (2000) 346 (3): 593–601.
Published: 07 March 2000
... Society, London © 2000 2000 endocytosis small G protein transferrin receptor recycling endosomes Biochem. J. (2000) 346, 593 601 (Printed in Great Britain) 593 Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles Bas NAGELKERKEN, Eelco VAN ANKEN...