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Keywords: transferrin receptorClose
Biochem J (2007) 406 (1): 1–12.
Published: 26 July 2007
... oncogenesis phosphoinositide 3-kinase (PI3K) transferrin receptor In 1972, Robert W. Holley, Nobel Laureate for his work demonstrating that tRNA interprets the genetic code, published a short “Unifying hypothesis concerning the nature of malignant growth” [ 1 ]. In this article, he suggested...
John Wilkinson, IV, Xiumin Di, Kai Schönig, Joan L. Buss, Nancy D. Kock, J. Mark Cline, Thomas L. Saunders, Hermann Bujard, Suzy V. Torti, Frank M. Torti
Biochem J (2006) 395 (3): 501–507.
Published: 11 April 2006
....), concurrent with a 4.5±2.1-fold (mean±S.D.) increase in transferrin receptor, indicating that overexpression of FerH is sufficient to elicit a phenotype of iron depletion. These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall...
Biochem J (2005) 388 (1): 143–150.
Published: 10 May 2005
... ferritin iron metabolism iron regulatory protein iron-responsive element transferrin receptor Iron is essential for a number of cellular functions, but when present in excess, it catalyses the generation of reactive oxygen species, and leads to tissue damage [ 1 ]. Consequently, iron metabolism...
Alessia CALZOLARI, Silvia DEAGLIO, Nadia Maria SPOSI, Eleonora PETRUCCI, Ornella MORSILLI, Marco GABBIANELLI, Fabio MALAVASI, Cesare PESCHLE, Ugo TESTA
Biochem J (2004) 381 (3): 629–634.
Published: 27 July 2004
...Alessia CALZOLARI; Silvia DEAGLIO; Nadia Maria SPOSI; Eleonora PETRUCCI; Ornella MORSILLI; Marco GABBIANELLI; Fabio MALAVASI; Cesare PESCHLE; Ugo TESTA Human TFR2 (transferrin receptor 2) is a membrane-bound protein homologous with TFR1. High levels of TFR2 mRNA were found mainly in the liver...
Biochem J (2004) 377 (1): 61–67.
Published: 01 January 2004
... liposomes. A biotinylated poly(ethylene glycol) (PEG)-phospholipid [bio-PEG-distearoylphosphatidylethanolamine (DSPE)] was used as a linker between a streptavidin-conjugated monoclonal antibody (mAb) (i.e. the OX26 mAb raised against the rat transferrin receptor) and 150 nm liposomes. OX26–streptavidin had...
Paige S. DAVIES, An-Sheng ZHANG, Emily L. ANDERSON, Cindy N. ROY, Michael A. LAMPSON, Timothy E. McGRAW, Caroline A. ENNS
Biochem J (2003) 373 (1): 145–153.
Published: 01 July 2003
...Paige S. DAVIES; An-Sheng ZHANG; Emily L. ANDERSON; Cindy N. ROY; Michael A. LAMPSON; Timothy E. McGRAW; Caroline A. ENNS HFE, the protein mutated in hereditary haemochromatosis type 1, is known to interact with the transferrin receptor (TfR) on the cell surface and during endocytosis [Gross...
Biochem J (2003) 370 (3): 891–899.
Published: 15 March 2003
..., manifested in the activation of iron-regulatory protein and concomitant increase in transferrin receptor levels and decrease in ferritin content. This phenotype persists in cells expressing wild-type HFE after transfection with a β 2 M cDNA. Whereas endogenous β 2 M is sufficient for the presentation...
Lorraine GAMBLING, Ruth DANZEISEN, Susan GAIR, Richard G. LEA, Zehane CHARANIA, Nita SOLANKY, Kavita D. JOORY, S. Kaila S. SRAI, Harry J. McARDLE
Biochem J (2001) 356 (3): 883–889.
Published: 08 June 2001
... iron transfer. Transferrin receptor expression was increased at both mRNA and protein levels. Similarly, expression of the iron-responsive element (IRE)-regulated form of the divalent metal transporter 1 (DMT1) was also increased. In contrast, the non-IRE regulated isoform showed no change in mRNA...
Bas NAGELKERKEN, Eelco VAN ANKEN, Marcel VAN RAAK, Lisya GEREZ, Karin MOHRMANN, Nathalie VAN UDEN, Jessica HOLTHUIZEN, Lucas PELKMANS, Peter VAN DER SLUIJS
Biochem J (2000) 346 (3): 593–601.
Published: 07 March 2000
... Society, London © 2000 2000 endocytosis small G protein transferrin receptor recycling endosomes Biochem. J. (2000) 346, 593 601 (Printed in Great Britain) 593 Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles Bas NAGELKERKEN, Eelco VAN ANKEN...