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Keywords: transforming growth factors
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Articles
Eleanor B. Reed, Albert Sitikov, Kun Woo D. Shin, Robert B. Hamanaka, Rengül Cetin-Atalay, Gökhan M. Mutlu, Alexander A. Mongin, Nickolai O. Dulin
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 1937–1948.
Published: 13 December 2024
... healing and pathogenesis of tissue fibrosis. Transforming growth factor-β (TGF-β) is the most powerful known driver of myofibroblast differentiation. TGF-β signals through transmembrane receptor serine/threonine kinases that phosphorylate Smad transcription factors (Smad2/3) leading to activation...
Includes: Supplementary data
Articles
Kylie A. Vestal, Chandramohan Kattamuri, Muhasin Koyiloth, Luisina Ongaro, James A. Howard, Aimee M. Deaton, Simina Ticau, Aditi Dubey, Daniel J. Bernard, Thomas B. Thompson
Journal:
Biochemical Journal
Biochem J (2024) 481 (7): 547–564.
Published: 10 April 2024
...Kylie A. Vestal; Chandramohan Kattamuri; Muhasin Koyiloth; Luisina Ongaro; James A. Howard; Aimee M. Deaton; Simina Ticau; Aditi Dubey; Daniel J. Bernard; Thomas B. Thompson Activins are one of the three distinct subclasses within the greater Transforming growth factor β (TGFβ) superfamily. First...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (9): 1733–1747.
Published: 10 May 2021
... transforming growth factors Growth differentiation factor 8 (GDF8), commonly known as myostatin, is a member of the larger transforming growth factor β (TGFβ) superfamily of signaling ligands and functions as a potent negative regulator of muscle mass [ 1–5 ]. Genetic deletion of GDF8 or use of GDF8...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (9): 1689–1703.
Published: 10 May 2021
... transforming growth factor β (TGF-β), a master regulator of the fibrotic signaling cascade. Based on mRNA and protein expression profiling data, we found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or TGF-β1-activated primary human HSCs. Unexpectedly, either...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (7): 1093–1107.
Published: 08 March 2017
... of 0.3 M sodium chlorate for 30–60 min. Following incubation, cells were washed and assessed by flow cytometry. BMP Gremlin-2 heparin transforming growth factors Bone morphogenetic proteins (BMPs), a subfamily of the greater transforming growth factor-β (TGF-β) superfamily, were...
Includes: Supplementary data