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Keywords: translation
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Biochem J (2024) 481 (3): 119–139.
Published: 29 January 2024
... [ 10 ], which suggested that even though mitochondrial protein import in vitro can occur post-translationally, the cell might also use localized translation and even co-translational import to help correct protein sorting in vivo [ 11 ]. The idea of localized translation at the mitochondrial...
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Biochem J (2022) 479 (10): 1059–1082.
Published: 23 May 2022
...Xuemin Wang; Christopher G. Proud Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and in many physiological, including homeostatic, responses. One long-known translational control mechanism involves phosphorylation of initiation factor, eIF2, which...
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Biochem J (2021) 478 (14): 2775–2788.
Published: 23 July 2021
... number of differentially translated genes and their moderate induction. There was almost no overlap between genes translationally regulated by pathogens or by S. indica . Genes involved in casparian strip formation and suberin biosynthesis were mildly down-regulated in cortical cells upon inoculation...
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Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... ) 1 3 2021 22 3 2021 29 3 2021 29 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation Cells within solid tumours may be subject...
Includes: Supplementary data
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Biochem J (2020) 477 (22): 4367–4381.
Published: 26 November 2020
... cells to escape from immunosurveillance. Ablation of eEF2K in prostate and lung cancer cells markedly reduced the expression levels of the PD-L1 protein. We show that eEF2K promotes the association of PD-L1 mRNAs with translationally active polyribosomes and that translation of the PD-L1 mRNA...
Includes: Supplementary data
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Biochem J (2020) 477 (16): 3033–3054.
Published: 26 August 2020
... leads to the accumulation of mitochondrial precursor proteins in the cytosol and activates several stress response pathways. These defense mechanisms engage a network of processes involving transcription, translation, and protein clearance to restore cellular protein homeostasis. In this review, we...
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Biochem J (2018) 475 (23): 3797–3812.
Published: 06 December 2018
... in polyamine-depleted cells. In addition, decreased levels of chondroitin synthase 1 (CHSY1) and chondroitin 4- O -sulfotransferase 2 proteins were also observed on polyamine depletion. Interestingly, the translation initiation of CHSY1 was suppressed by a highly structured sequence (positions −202 to −117...
Includes: Supplementary data
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Biochem J (2018) 475 (10): 1721–1738.
Published: 24 May 2018
... ) 11 2 2018 19 4 2018 23 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 mechanistic target of rapamycin post-translational modification translation Crystal structures have been determined for both Sin1 and its...
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Biochem J (2016) 473 (11): 1641–1649.
Published: 27 May 2016
...Yanwu Li; Gang Chen; Jun-Yao Wang; Tongtong Zou; Lan Liu; Lan Xiao; Hee Kyoung Chung; Jaladanki N. Rao; Jian-Ying Wang MicroRNAs (miRNAs) control gene expression by binding to their target mRNAs for degradation and/or translation repression and are implicated in many aspects of cellular physiology...
Includes: Supplementary data
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Biochem J (2015) 472 (1): 111–119.
Published: 30 October 2015
... journey to the cytoplasm, where it participates in translation. However, due to the size, complexity and variability of the mRNP, it remains technically challenging to assess its impact on translation. By designing a novel in vitro translational assay, we have been able to compare the translational...
Includes: Supplementary data
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Biochem J (2015) 467 (1): 63–76.
Published: 20 March 2015
... in humidified air with 5% CO 2 . The MAP kinase-interacting kinases (Mnk1 and Mnk2) are activated by ERK and are best known for phosphorylating the translation initiation factor eIF4E. Genetic knockout of the Mnks impaired the migration of embryonic fibroblasts both in two-dimensional wound-healing...
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Biochem J (2015) 467 (1): 91–102.
Published: 20 March 2015
... cells. However, whether GQSs form and are functional in plants remains essentially unexplored. On the basis of circular dichroism (CD)-detected titration, UV-detected melting, in-line probing (ILP) and reporter gene assay studies, we report the first example of a plant RNA GQS that inhibits translation...
Includes: Supplementary data
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Biochem J (2015) 465 (2): 213–225.
Published: 06 January 2015
...Anne Roobol; Jo Roobol; Amandine Bastide; John R. P. Knight; Anne E. Willis; C. Mark Smales One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α (eukaryotic translation initiation factor 2α). This is mediated...
Includes: Supplementary data
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Biochem J (2014) 462 (2): 373–384.
Published: 07 August 2014
... this, we have conducted a molecular characterization of this aMBF1. Affinity purification of interacting proteins indicates that aMBF1 binds to ribosomal subunits. On sucrose density gradients, aMBF1 co-fractionates with free 30S ribosomal subunits as well as with 70S ribosomes engaged in translation...
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Biochem J (2014) 457 (2): 231–242.
Published: 20 December 2013
... functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss...
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Biochem J (2013) 455 (1): 67–73.
Published: 13 September 2013
...Michael Aregger; Victoria H. Cowling Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II...
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Biochem J (2013) 453 (1): 71–82.
Published: 13 June 2013
.... Chapkin R. S. Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesis Cancer Prev. Res. 2009 2 984 994 7 Kudo K. Xi Y. Wang Y. Song B. Chu E. Ju J. Russo J. J. Translational control analysis by translationally...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 681–692.
Published: 24 February 2012
...Sébastien Pyr Dit Ruys; Xuemin Wang; Ewan M. Smith; Gaëtan Herinckx; Nusrat Hussain; Mark H. Rider; Didier Vertommen; Christopher G. Proud eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main...
Includes: Supplementary data
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Biochem J (2010) 431 (1): 31–38.
Published: 14 September 2010
...L. Ashley Cowart; Jason L. Gandy; Baby Tholanikunnel; Yusuf A. Hannun Recent work, especially in the yeast Saccharomyces cerevisiae , has demonstrated that mRNA movement from active translation to cytoplasmic granules, termed mRNA‘p-bodies’ (processing bodies), occurs in concert with the regulation...
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Biochem J (2010) 430 (3): 551–558.
Published: 27 August 2010
.../by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Era G-protein-like 1 (ERAL1) mitoribosome ribosome assembly rRNA translation Mammalian mitochondria possess their own genome, mtDNA...
Includes: Supplementary data
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Biochem J (2010) 429 (1): 43–51.
Published: 14 June 2010
... dimorphism translation Wild-type C57BL/6J mice were obtained from Charles River and were bred on regular lab chow (Altromin). A time-course analysis of selenoprotein expression after a single injection of LPS was conducted as described previously [ 28 ]. In addition, transgenic mice on a C57BL/6...
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Biochem J (2010) 426 (3): 319–326.
Published: 24 February 2010
... and squamous carcinomas of the lung. Despite the down-regulation of the protein, tumour β-mRNA levels remained either unchanged (breast and lung adenocarcinomas) or significantly increased (colon and squamous lung carcinomas) when compared with paired normal tissues, suggesting a specific translation-masking...
Includes: Supplementary data
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Biochem J (2010) 425 (2): 295–302.
Published: 23 December 2009
...Victoria H. Cowling The 7-methylguanosine cap added to the 5′ end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some...
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Biochem J (2008) 414 (1): 19–29.
Published: 29 July 2008
... integrate with HIF and how other cellular pathways such as chromatin remodelling, translation regulation and microRNA induction, contribute to the co-ordinated cellular response observed following hypoxic stress. 1 To whom correspondence should be addressed (email s.rocha@dundee.ac.uk ). 29 5...
Includes: Multimedia, Supplementary data
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Biochem J (2006) 400 (2): 377–383.
Published: 14 November 2006
...Paulina Wakula; Monique Beullens; Aleyde van Eynde; Hugo Ceulemans; Willy Stalmans; Mathieu Bollen It is reasonably well understood how the initiation of translation is controlled by reversible phosphorylation of the eukaryotic translation initiation factors eIF2α, eIF2Bϵ and eIF4E. Other...
Includes: Supplementary data
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Biochem J (2006) 400 (1): 99–104.
Published: 27 October 2006
... translation Plant RIPs (ribosome-inactivating proteins) are potent toxins that kill cells by inactivating ribosomes [ 1 ]. RIPs catalytically depurinate major rRNA by exerting a highly specific N-glycosidase activity that cleaves an adenine base, A4324, which forms part of a tetranucleotide ‘GA 4324...
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Biochem J (2006) 399 (2): 249–256.
Published: 27 September 2006
... mitochondrial translation system employs two different EF-Tu factors named EF-Tu1 and EF-Tu2. Our previous study showed that nematode Caenorhabditis elegans EF-Tu1 binds specifically to T-armless tRNA. C. elegans EF-Tu1 has a 57-amino acid C-terminal extension that is absent from canonical EF-Tu, and the T-arm...
Includes: Supplementary data
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Biochem J (2006) 396 (2): 219–226.
Published: 15 May 2006
...Enrique Álvarez; Alfredo Castelló; Luis Menéndez-Arias; Luis Carrasco The PABP [poly(A)-binding protein] is able to interact with the 3′ poly(A) tail of eukaryotic mRNA, promoting its translation. Cleavage of PABP by viral proteases encoded by several picornaviruses and caliciviruses plays a role...
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Biochem J (2004) 384 (2): 239–246.
Published: 23 November 2004
...Cornelia BRENDEL; Monika REHBEIN; Hans-Jürgen KREIENKAMP; Friedrich BUCK; Dietmar RICHTER; Stefan KINDLER In Drosophila oocytes and neuroblasts, the double-stranded RNA binding protein Staufen assembles into ribonucleoprotein particles, which mediate cytoplasmic mRNA trafficking and translation...
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Biochem J (2004) 380 (3): 823–830.
Published: 15 June 2004
... a mechanism for translational regulation of these mRNAs. However, future experiments are required to ident- ify mRNAs that are translationally regulated by Scp160p. The intracellular distribution of Asc1p changes in cells entering stationary phase. In these cells, a significant amount of Asc1p was found...
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Biochem J (2003) 369 (2): 369–374.
Published: 15 January 2003
... examined. Translation of globin mRNA by rabbit reticulocyte lysate decreased by 30—60% when osmolality was increased from 0.35 to 0.53osmol/kg of water by the addition of NaCl, KCl, CH 3 CO 2 Na or CH 3 CO 2 K. In contrast, equivalent additions of the compatible osmolytes betaine or myo -inositol caused...
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