... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Bax Bcl-2 BH3-only proteins protein–protein interactions transmembrane domain When a eukaryotic cell is faced with overwhelming cellular stress that surpasses...

.... Correspondence: Daniel J. Leahy ( [email protected] ) 8 9 2022 1 11 2022 23 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Akt EGFR Erk phosphotyrosine signaling transmembrane domain The Epidermal Growth...

... by the positively charged transmembrane domain S4. The best-characterized K V channel, KvAP, lacks the distinct hydrophilic region corresponding to the S3–S4 extracellular loop that is found in other K + channels. In the present study, we evaluated the topogenic properties of the transmembrane regions within...

.... To identify the residues of Hgt1p critical for substrate binding and translocation, all amino acid residues of the 13 predicted transmembrane domains (TMDs) have been subjected to mutagenesis. Functional evaluation of these 269 mutants by growth and biochemical assay followed by kinetic analysis...

... from the plasma membrane through endocytosis, to be distributed to multivesicular bodies and lysosomes. In addition to the canonical nucleotide-binding domain (NBD) and transmembrane domain (TMD), ABCB6 contains a unique N-terminal TMD (TMD 0 ), which does not show sequence homology to known proteins...

... the neuroligin transmembrane domain, ensuring that dimerization occurs prior to cell surface trafficking. Lastly, we identified differences in the dimerization capacity of autism-associated neuroligin mutants, and found that neuroligin 3 R471C mutants can form heterodimers with neuroligin 1. The pervasive nature...

... hydroxylase motif phenylalanine hydroxylase tetrahydrobiopterin transmembrane domain Alkylglycerol mono-oxygenase (glycerylether mono-oxygenase, EC 1.14.16.5) is the only enzyme known to cleave the ether bond of alkylglycerols [ 1 ]. Alkylglycerols form an abundant and diverse class of lipids...

... (CFTR) disulphide cross-linking misprocessed mutant transmembrane domain transmembrane segment packing CL4 of CFTR is a hot-spot for CF-associated mutations because mutations to about one-third of the residues in CL4 (between residues 1052 and 1098) have been linked to patients diagnosed...

..., displayed wild-type properties in a yeast expression system, indicating that endogenous cysteine residues are not essential for hCNT3-mediated nucleoside transport. A series of cysteine-substitution mutants spanning predicted TMs (transmembrane domains) 11–13 was constructed and tested for accessibility...

... of LmAPX is characterized by a charged region followed by a stretch of 22 amino acids containing a transmembrane domain. To understand how the transmembrane domain influences the structure–function of LmAPX, we generated, purified and extensively characterized a variant that lacked the transmembrane domain...

...Neta SAL-MAN; Yechiel SHAI The interactions between the TM (transmembrane) domains of many membrane proteins are important for their proper functioning. Mutations of residues into positively charged ones within TM domains were reported to be involved in many genetic diseases, possibly because...

...Wei CAO; Larry H. MATHERLY The hRFC (human reduced folate carrier) is the major membrane transporter for both reduced folates and antifolates in human tissues and tumours. The primary amino acid sequence of hRFC predicts a membrane topology involving 12 TMDs (transmembrane domains) with cytosolic...