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Keywords: transmissible
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Biochem J (2017) 474 (19): 3253–3267.
Published: 20 September 2017
... protein gene PRNP and accumulation of PrP Sc , an abnormal isomer of the normal host protein PrP C , in the brain of affected individuals. PrP Sc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate...
Includes: Supplementary data
Biochem J (2016) 473 (23): 4399–4412.
Published: 25 November 2016
...-infected sheep brain homogenate. Significantly, we determined that this prion-induced neurotoxic response in ovine PrP transgenic Drosophila was transmissible to ovine PrP transgenic mice, which is indicative of authentic mammalian prion detection by these flies. As a consequence, we considered that PrP...
Biochem J (2014) 463 (1): 31–40.
Published: 08 September 2014
...Alana M. Thackray; Ying Di; Chang Zhang; Hanna Wolf; Lydia Pradl; Ina Vorberg; Olivier Andréoletti; Raymond Bujdoso Prion diseases are fatal transmissible neurodegenerative diseases of various mammalian species. Central to these conditions is the conversion of the normal host prion protein PrP C...
Includes: Supplementary data