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Keywords: tuberculosis
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Articles
Biochem J (2021) 478 (11): 2081–2099.
Published: 08 June 2021
... synthesis of peptidoglycan and other cell wall components. The absence of a homolog in eukaryotes makes GlmU an attractive target for therapeutic intervention. Mycobacterium tuberculosis GlmU (GlmU Mt ) has features, such as a C-terminal extension, that are not present in GlmU orthologs from other bacteria...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (23): 4473–4489.
Published: 03 December 2020
... phosphorylation, nitrosylation, and pupylation modulate multiple cellular processes in Mycobacterium tuberculosis . While protein methylation at lysine and arginine residues is widespread in eukaryotes, to date only two methylated proteins in Mtb have been identified. Here, we report the identification of...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (19): 3123–3140.
Published: 12 October 2018
...Flavia Squeglia; Alessia Ruggiero; Rita Berisio The scenario of chemical reactions prompted by the infection by Mycobacterium tuberculosis is huge. The infection generates a localized inflammatory response, with the recruitment of neutrophils, monocytes, and T-lymphocytes. Consequences of this...
Articles
Biochem J (2014) 461 (1): 87–98.
Published: 13 June 2014
... tuberculosis ( Mtb ). AnPRT catalyses the Mg 2+ -dependent transfer of a phosphoribosyl group from PRPP (5′-phosphoribosyl-1′-pyrophosphate) to anthranilate to form PRA (5′-phosphoribosyl anthranilate). Mtb -AnPRT was shown to catalyse a sequential reaction and significant substrate inhibition by anthranilate...
Articles
Biochem J (2014) 459 (3): 467–478.
Published: 11 April 2014
... known about Fe–S cluster biogenesis in other bacterial species. The ISC (iron–sulfur cluster) operon of Mycobacterium tuberculosis lacks several genes known to be essential for the function of this system in other organisms. However, the cysteine desulfurase IscSMtb (Rv number Rv3025c; Mtb denotes M...
Includes: Supplementary data
Articles
Biochem J (2014) 458 (2): 387–394.
Published: 14 February 2014
...Sachin Surade; Nancy Ty; Narin Hengrung; Benoit Lechartier; Stewart T. Cole; Chris Abell; Tom L. Blundell A structure-guided fragment-based approach was used to target the lipophilic allosteric binding site of Mycobacterium tuberculosis EthR. This elongated channel has many hydrophobic residues...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 417–427.
Published: 25 November 2010
...Laura J. Smith; Melanie R. Stapleton; Gavin J. M. Fullstone; Jason C. Crack; Andrew J. Thomson; Nick E. Le Brun; Debbie M. Hunt; Evelyn Harvey; Salvatore Adinolfi; Roger S. Buxton; Jeffrey Green Mycobacterium tuberculosis is a major pathogen that has the ability to establish, and emerge from, a...
Articles
Biochem J (2005) 392 (3): 615–624.
Published: 06 December 2005
... and Mycobacterium tuberculosis , the aetiological agent of tuberculosis in humans, are thought to be central to anti-mycobacterial immunity. We have previously shown that M. tuberculosis binds to human monocyte-derived dendritic cells mostly through the C-type lectin DC-SIGN (dendritic-cell-specific...
Articles
Biochem J (2002) 365 (1): 89–97.
Published: 01 July 2002
...Stéphane SIDOBRE; Germain PUZO; Michel RIVIÈRE The human pulmonary surfactant protein A (hSP-A), a member of the mammalian collectin family, is thought to play a key defensive role against airborne invading pulmonary pathogens, among which is Mycobacterium tuberculosis , the aetiologic agent of...
Articles
Biochem J (1999) 343 (3): 669–672.
Published: 25 October 1999
...Bernd HUTTER; Mahavir SINGH The 40 kDa antigen of Mycobacterium tuberculosis is the first antigen reported to be present in the pathogenic M. tuberculosis , but not in the vaccine strain Mycobacterium bovis BCG. It is a functional L -alanine dehydrogenase (EC 1.4.1.1) and hence one of the few...