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Keywords: tubulin
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Biochem J (2015) 472 (3): 367–377.
Published: 27 November 2015
..., but its cytoplasmic roles are still not elucidated fully. We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3. A brief 1 h treatment of PC3 cells with MI192 significantly increased levels of tubulin...
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Biochem J (2014) 462 (2): 231–245.
Published: 07 August 2014
... [S-(2-succino)cysteine]. We demonstrate that both α- and β-tubulin are increasingly modified by succination in 3T3-L1 adipocytes and in the adipose tissue of db / db mice. Incubation of purified tubulin from porcine brain with fumarate (50 mM) or the pharmacological compound DMF (dimethylfumarate...
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Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
... The Biochemical Society, London 2006 antiangiogenesis anticancer agent cytochrome P450 microtubule tubulin tubulysin A Most drugs currently available for the treatment of cancer are mechanistically based on the inhibition of cell proliferation and induction of apoptosis. These include cytotoxic...
Includes: Supplementary data
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Biochem J (2005) 389 (2): 549–558.
Published: 05 July 2005
...P. J. Britto; Leslie Knipling; Peter Mcphie; J. Wolff All 20 cysteine residues are accessible to disulphide reagents in the tubulin dimer, whereas only four are accessible in taxol-stabilized microtubules. Reaction rates with disulphide reagents are a function of the reagent, are decreased by G...
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Biochem J (1999) 340 (2): 411–416.
Published: 25 May 1999
... DNA fragmentation was observed in both P388 and HL-60 cells, the antitumour activity of pironetin is thought to be due to the induction of apoptosis. Pironetin also induced the rapid phosphorylation of Bcl-2 before formation of the DNA ladder in HL-60 cells, as seen with several tubulin binders...