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1-11 of 11
Keywords: tubulin
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Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
... myosin (NM) isoforms (IIA > IIC > IIB) leading to the redistribution of actomyosin filaments to enhance cell migration. Using COS-7 cells which do not naturally express NMIIA, S100P is now shown to interact directly with α,β-tubulin in vitro and in vivo with an equilibrium K d of 2–3 × 10 −7 M...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (10): 1401–1417.
Published: 21 May 2019
... K274-tau. We incorporated an acetylation mimicking mutation at K274 (K→Q) residue of tau. The mutation (K274Q) strongly reduced the ability of tau to bind to tubulin and also to polymerize tubulin while K274R mutation did not reduce the ability of tau either to bind or polymerize tubulin. In addition...
Includes: Supplementary data
Articles
Travis Bacon, Caroline Seiler, Marcin Wolny, Ruth Hughes, Peter Watson, John Schwabe, Ronald Grigg, Michelle Peckham
Journal:
Biochemical Journal
Biochem J (2015) 472 (3): 367–377.
Published: 27 November 2015
..., but its cytoplasmic roles are still not elucidated fully. We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3. A brief 1 h treatment of PC3 cells with MI192 significantly increased levels of tubulin...
Articles
Gerardo G. Piroli, Allison M. Manuel, Michael D. Walla, Matthew J. Jepson, Jonathan W. C. Brock, Mathur P. Rajesh, Ross M. Tanis, William E. Cotham, Norma Frizzell
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 231–245.
Published: 07 August 2014
... [S-(2-succino)cysteine]. We demonstrate that both α- and β-tubulin are increasingly modified by succination in 3T3-L1 adipocytes and in the adipose tissue of db / db mice. Incubation of purified tubulin from porcine brain with fumarate (50 mM) or the pharmacological compound DMF (dimethylfumarate...
Articles
Nagma Khan, Michael Jeffers, Sampath Kumar, Craig Hackett, Ferenc Boldog, Nicholai Khramtsov, Xiaozhong Qian, Evan Mills, Stanny C. Berghs, Nessa Carey, Paul W. Finn, Laura S. Collins, Anthony Tumber, James W. Ritchie, Peter Buhl Jensen, Henri S. Lichenstein, Maxwell Sehested
Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 581–589.
Published: 21 December 2007
... resulted in increased acetylation of histones, but only pan-HDAC inhibitor treatment resulted in increased tubulin acetylation, which is in agreement with their activity towards the HDAC6 isoform. 1 To whom correspondence should be addressed (e-mail [email protected] ). 11 6 2007 7...
Includes: Supplementary data
Articles
Gurmeet Kaur, Melinda Hollingshead, Susan Holbeck, Vesna Schauer-Vukašinović, Richard F. Camalier, Alexander Dömling, Seema Agarwal
Journal:
Biochemical Journal
Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
... The Biochemical Society, London 2006 antiangiogenesis anticancer agent cytochrome P450 microtubule tubulin tubulysin A Most drugs currently available for the treatment of cancer are mechanistically based on the inhibition of cell proliferation and induction of apoptosis. These include cytotoxic...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 549–558.
Published: 05 July 2005
...P. J. Britto; Leslie Knipling; Peter Mcphie; J. Wolff All 20 cysteine residues are accessible to disulphide reagents in the tubulin dimer, whereas only four are accessible in taxol-stabilized microtubules. Reaction rates with disulphide reagents are a function of the reagent, are decreased by G...
Articles
Isabelle JOURDAIN, Sylvie LACHKAR, Elodie CHARBAUT, Benoit GIGANT, Marcel KNOSSOW, André SOBEL, Patrick A. CURMI
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 877–888.
Published: 15 March 2004
... microtubule dynamics by sequestering tubulin in a complex made of two tubulin heterodimers per stathmin molecule (T 2 S complex). The other proteins of the stathmin family can also bind two tubulin heterodimers through their SLD (stathmin-like domain), but the different tubulin:SLD complexes display varying...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 121–129.
Published: 01 October 2003
...Silvia A. PURRO; C. Gastón BISIG; María A. CONTIN; Héctor S. BARRA; Carlos A. ARCE Detyrosination/tyrosination of tubulin is a post-translational modification that occurs at the C-terminus of the α-subunit, giving rise to microtubules rich in either tyrosinated or detyrosinated tubulin which...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 352 (2): 267–276.
Published: 24 November 2000
..., Milton Road, Cambridge CB4 0GZ, U.K. 2 To whom correspondence should be addressed (e-mail [email protected] ). 15 6 2000 25 8 2000 3 10 2000 The Biochemical Society, London © 2000 2000 glucose transport signalling tubulin vesicle dynamics Biochem. J. (2000...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (2): 411–416.
Published: 25 May 1999
... DNA fragmentation was observed in both P388 and HL-60 cells, the antitumour activity of pironetin is thought to be due to the induction of apoptosis. Pironetin also induced the rapid phosphorylation of Bcl-2 before formation of the DNA ladder in HL-60 cells, as seen with several tubulin binders...