... A (POLGA) has been shown to be a key factor, which can be modulated to change the mtDNA copy number and cell fate of differentiating and tumour cells. The present review combines multi-disciplinary data from mitochondria, development, epigenetics and tumorigenesis, which could provide novel insights...

... to ensure HER3 signalling throughput identify HER3 as a major signalling hub in HER2-amplified cancers and a highly resourceful guardian of tumorigenic signalling in these tumours. ErbB3 human epidermal growth factor receptor 2 (HER2) human epidermal growth factor receptor 3 (HER3) tumorigenesis...

.... Surprisingly, most tumour suppressor mechanisms co-ordinated by p38α have been reported to occur at the post-translational level. This contrasts with the important role of p38α in the regulation of transcription and the profound changes in gene expression that normally occur during tumorigenesis. We have...

.... 23 7 2010 25 8 2010 6 9 2010 6 9 2010 DNA base excision repair frataxin Friedreich's ataxia iron–sulfur cluster oxidative stress tumorigenesis ISCs (iron–sulfur clusters) are small inorganic molecules that can be found in all kingdoms of life. Being integrated...

... heterodimer partner (SHP) tumorigenesis Gli (glioma-associated oncogene homologue) was identified as a gene that is amplified in gliomas [ 1 ] and it acts as a terminal effector of the Hedgehog signalling pathway [ 2 ]. Typically, Hedgehog signalling is initiated by the binding of Hedgehog ligand...

... with mPGES-1 knockdown or overexpression, as well as mPGES-1-deficient mice to examine the roles of cancer cell- and host-associated mPGES-1 in the processes of tumorigenesis in vitro and in vivo . We found that siRNA (small interfering RNA) silencing of mPGES-1 in LLC cells decreased PGE 2 synthesis...

... architecture. However, tyrosine to alanine substitution at the other NPXY 29 motif had no effect on cell growth or tumorigenesis. These results suggest that the FXNPXY 63 motif of LRP1 not only governs cellular localization of the receptor but also exerts multiple functional effects on signalling pathways...

... for iPLA 2 in cell cycle progression and tumorigenesis of ovarian carcinoma cells. PLA 2 (phospholipase A 2 ) enzymes have been implicated in activation of cell migration as well as in production of LPA in ovarian carcinoma cells [ 7 – 11 ]. PLA 2 catalyses the hydrolysis of glycerophospholipids...

... Regional de Hemodonación, Ronda de Garay, s/n, 30003 Murcia, Spain. 5 12 2003 9 1 2004 9 1 2004 The Biochemical Society, London ©2004 2004 colorectal cancer Smad complex Smad4 TGF-β (transforming growth factor β) signalling tumour suppressor tumorigenesis...