... transferase P1-1 (GSTP1-1) histones nitric oxide (NO) tumour cell The cells, either untreated or treated for up to 4 h, were sonicated with three pulses for 2 s in 0.1 ml of 10 mM Tris/HCl, pH 7.4 at room temperature (25°C) using a Vibra Cell Sonicator (Sonics and Materials). The HPLC determination...

... oxygen consumption tumour cell Cancer cells depend on large quantities of energy to maintain elevated rates of proliferation. In this regard, specific adaptations in energy-yielding pathways are observed, including activation of glycolysis and down-regulation of oxidative phosphorylation, also...

... Society, London 2004 blast cell cAMP-response-element-binding protein (CREB) inflammation leukaemia NALP1 tumour cell NALP1 (also called DEFCAP, NAC and CARD7) belongs to a newly identified family of cytoplasmic proteins that have been implicated in cell responses to apoptotic...

... by vacuolar H + -ATPases, which can be selectively inhibited by bafilomycin-A 1 . Here, we treated human tumour cell lines expressing MT1-MMP with bafilomycin-A 1 , and analysed its effects on MT1-MMP activity, internalization and processing. We show that the activity of MT1-MMP on the cell surface...

... of the tumour cells. Tumour and transformed cells are known to exhibit profound metabolic deviations, including aerobic glycolysis, glutaminolysis, Crabtree effect, and enhanced nucleic acid and lipid syntheses [7]. The metabolic deviations and consequent demand for nutriments by cancer cells are then not only...