... PAR2. Hence, we suggest CHI3L1 to be an autoprotective factor that is activated to protect skeletal muscle from the negative effect of TNFα. chitinase-3-like protein 1 (CHI3L1) inflammation myokine skeletal muscle cell tumour necrosis factor α (TNFα) 28 8 2013 6 2 2014 11...

... ]; RelA, GCUGAUGUGCACCGACAAG [ 13 ]; TfR1_A, CCAAUACAGAGCAGACAUA; TfR1_B, ACUUGCUGUAGAUGAAGAA; TfR1_C, CUUCCAGACUAACAACAGA; and IKKγ, ACAGGAGGUGAUCGAUAAG [ 14 ]. inhibitor of nuclear factor κB kinase (IKK) iron nuclear factor κB (NF-κB) transferrin transferrin receptor 1 (TfR1) tumour necrosis...

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bioinformatics cytokine inflammation promoter PIK3CD tumour necrosis factor α (TNFα) Antibodies were as follows: anti...

... phospholipase A 2 (PLA2G4C) inflammation lung tumour necrosis factor α (TNFα) The initial physiological response to infection or tissue injury is inflammation. A defining event in this response is the liberation of bioactive lipid metabolites of AA (arachidonic acid), the eicosanoids...

...)-associated nuclear factor κB activator]-binding kinase 1 (TBK1) tumour necrosis factor α (TNFα) Toll-like receptor (TLR) Pellino was originally discovered in the Toll signalling pathway of Drosophila melanogaster as a protein that interacts with Pelle, the orthogue of IRAK {IL-1R [IL (interleukin...

... XAP2) cAMP-specific phosphodiesterase-4 (PDE4) disrupted in schizophrenia 1 (DISC1) mitogen-activated protein kinase-activated protein kinase 2 (MK2 also called MAPKAPK2) protein kinase A (PKA) tumour necrosis factor α (TNFα) MAPKs (mitogen-activated protein kinases) provide...

... gene expression inhibitory κB β (IκBβ) nuclear factor κB (NF-κB) tumour necrosis factor α (TNFα) NF-κB (nuclear factor κB) is a homo- or hetero-dimeric inducible transcription factor composed of several mammalian Rel proteins: p65 (RelA), p50 (NFKB1), p52 (NFKB2), c-Rel and RelB [ 1...

... mitogen-activated protein kinase (MAPK) mixed lineage kinase 3 (MLK3) proteasome tumour necrosis factor α (TNFα) The activities and signalling pathways of many protein kinases are controlled through post-translational modifications. Reversible phosphorylation is the most common post...

... (CXCL2)/macrophage inflammatory protein 2 (MIP2) histone acetylation histone deacetylase 1 (HDAC1) nuclear factor κB (NF-κB) RelA (p65) tumour necrosis factor α (TNFα) 1 To whom correspondence should be addressed (email [email protected] ). Primers used were: Cxcl1 (FWD...

... should be addressed (email [email protected] ). 18 6 2009 18 9 2009 2 10 2009 2 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 G-protein-coupled-receptor kinase (GRK) inflammation macrophage nuclear factor κB (NF-κB) tumour necrosis factor...

... 30 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 blood–testis barrier coxsackie- and adenovirus-receptor-like membrane protein (CLMP) post-transcriptional regulation Sertoli cell tight junction tumour necrosis factor α (TNFα...

... kinase 1 (TAK1) tumour necrosis factor α (TNFα) The uncontrolled production of TNFα (tumour necrosis factor α) and other pro-inflammatory cytokines is a major cause of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. TAK1 (transforming growth factor-β...

... 2 2007 8 8 2007 10 8 2007 10 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 CCAAT/enhancer-binding protein (C/EBP) HL60 cell phospholipid hydroperoxide glutathione peroxidase (PHGPx) promoter activity tumour necrosis factor α (TNFα...

... should be addressed (email [email protected] ). 28 2 2007 25 6 2007 9 7 2007 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 α-difluromethylornithine (DFMO) epithelium p130Cas polyamine Src tumour necrosis factor α (TNFα...

... hepatocyte nuclear factor 4 (HNF-4) nuclear factor κB (NF-κB) transcriptional inhibition tumour necrosis factor α (TNFα) HNF-4 (hepatocyte nuclear factor 4) belongs to the hormone nuclear receptor gene superfamily of transcription factors on the basis of its domain architecture, which...

... in 62.5 mM Tris/HCl, pH 6.8, for 30 min at 70 °C. 6 2 2006 24 3 2006 27 3 2006 27 3 2006 The Biochemical Society, London 2006 anaemia of chronic disease (ACD) ferritin hypoferraemia iron iron-regulated protein 1 (IREG1) tumour necrosis factor α (TNFα...

.... apoptosis cathepsin D lysosome NPe6 3- O -methylsphingomyelin photodynamic therapy procaspase tumour necrosis factor α (TNFα) The reagents and procedures used for the preparation and processing of cell lysates, SDS gel electrophoresis and immunodetection of caspase 3 have been described...

....). adenosine receptor ATL146e inflammation lipopolysaccharide macrophage tumour necrosis factor α (TNFα) Adenosine released from stressed cells can act as a physiological inhibitor of inflammation [ 1 ]. Utilization of ATP during periods of high metabolic activity leads to an increased...

... To whom correspondence should be addressed (email [email protected] ). 12 5 2005 4 7 2005 13 7 2005 13 7 2005 The Biochemical Society, London 2005 activator protein 1 (AP-1) glutamate–cysteine ligase (GCL) GSH synthetase (GSS) nuclear factor κB (NF-κB) tumour necrosis...

... factor-κB1 (NF-κB1) RelA homodimer tumour necrosis factor α (TNFα) In a variety of cell types, cytokines regulate the expression of many viral and cellular genes through the transcriptional factor NF-κB (nuclear factor κB) (reviewed in [ 1 – 3 ]). NF-κB was first described as a heterodimer...

[email protected] ). 22 9 2004 27 10 2004 29 10 2004 29 10 2004 The Biochemical Society, London 2005 apoptosis Bax translocation ceramide mitochondrion sphingomyelinase tumour necrosis factor α (TNFα) Several studies have demonstrated strong links between ceramide...