...David W. Meek p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cancer cells and eliminates them through senescence (a permanent non-proliferative state) or apoptosis. Consistent with this role, p53 activity is compromised in a high proportion of all...

... via an ubiquitin ligase complex together with DDB1 and CUL4A (cullin 4A). PAQR3 (progestin and adipoQ receptor family member III) is a newly discovered tumour suppressor that is implicated in the development of many types of human cancers. In the present paper, we report that DDB2 is involved...

...-binding protein 5) is a tumour suppressor gene (TSG) that maps to a region of consistent deletion on 1p36.31 in neuroblastomas (NBs) and other tumour types. CHD5 encodes a protein with chromatin remodelling, helicase and DNA-binding motifs that is preferentially expressed in neural and testicular tissues...

... antibodies against Ser 487 /Ser 491 on AMPK-α1/α2 (pS487/p491), Ser 9 on GSK3β (pS9), Thr 308 and Ser 473 on Akt (pT308, pS473), and Thr 389 on S6K1 (S6 kinase 1) (pT389) were from Cell Signaling Technology. Akt AMP-activated protein kinase (AMPK) cancer cross-talk tumour suppressor...

... classified as type II tumour suppressors on the basis of reports describing their down-regulation and mislocalization in a variety of cancer types. In addition to their regulation by transcriptional mechanisms, understanding the range of PTMs (post-translational modifications) of INGs is important...

... 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 histone deacetylase (HDAC) signal transducer and activator of transcription 3 (STAT3) solute carrier gene family 5A member 8 (SLC5A8) survivin tumour suppressor SLC5A8 (solute carrier gene family 5A, member...

...Inma M. Berenjeno; Julie Guillermet-Guibert; Wayne Pearce; Alexander Gray; Stewart Fleming; Bart Vanhaesebroeck The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted...

... for this link remains unclear. Studies in Drosophila have uncovered complex interactions between the conserved Hpo (Hippo) tumour suppressor pathway and apico–basal polarity determinants. The Hpo pathway is a crucial growth regulatory network whose inactivation in Drosophila epithelial tissues induces massive...

...Lu Jiang; Xiqiang Liu; Zujian Chen; Yi Jin; Caroline E. Heidbreder; Antonia Kolokythas; Anxun Wang; Yang Dai; Xiaofeng Zhou miR-7 (microRNA-7) has been characterized as a tumour suppressor in several human cancers. It targets a number of proto-oncogenes that contribute to cell proliferation...

...Victoria Sherwood; Asha Recino; Alex Jeffries; Andrew Ward; Andrew D. Chalmers The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups...

...Helene Maccario; Nevin M. Perera; Lindsay Davidson; C. Peter Downes; Nick R. Leslie Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of mutation appears to occur...

...Lyne Jossé; Margaret E. Harley; Isabel M. S. Pires; David A. Hughes Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast...

...Natalia V. Oleinik; Natalia I. Krupenko; David G. Priest; Sergey A. Krupenko A folate enzyme, FDH (10-formyltetrahydrofolate dehydrogenase; EC 1.5.1.6), is not a typical tumour suppressor, but it has two basic characteristics of one, i.e. it is down-regulated in tumours and its expression...

...Nick R. LESLIE; C. Peter DOWNES The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular...

... autoactivation is also evident when purified recombinant FLAG–NORE is added to purified, recombinant MST1 in vitro (Figure 4 D). Thus the binding of NORE to MST1 appears to be sufficient to inhibit MST1 autoactivation. MST1 MST2 NORE1 Ras RASSF1 tumour suppressor MST1 (mammalian Sterile20...

...Karolien DE BOSSCHER; Caroline S. HILL; Francisco J. NICOLÁS Smad4 is an essential signal transducer of the transforming growth factor β (TGF-β) signalling pathway and has been identified as a tumour suppressor, being mutated in approx. 50% of pancreatic cancers and approx. 15% of colorectal...

...Jérôme BOUDEAU; Maria DEAK; Margaret A. LAWLOR; Nick A. MORRICE; Dario R. ALESSI LKB1 is a widely expressed serine/threonine protein kinase that is mutated in the inherited Peutz—Jeghers cancer syndrome. Recent findings indicate that LKB1 functions as a tumour suppressor, but little is known...

...Saori FURUTA; Fausto ORTIZ; Xiu ZHU SUN; Hsiao-Huei WU; Andrew MASON; Jamil MOMAND The p53 tumour-suppressor protein is a transcription factor that activates the expression of genes involved in cell cycle arrest, apoptosis and DNA repair. The p53 protein is vulnerable to oxidation at cysteine thiol...

...Nicolas DUMAZ; Diane M. MILNE; Lesley J. JARDINE; David W. MEEK The p53 tumour suppressor protein is a short-lived transcription factor that becomes stabilized in response to a wide range of cellular stresses. Ubiquitination and the targeting of p53 for degradation by the proteasome are mediated...

...Eric HAN; Dillon PHAN; Piao LO; Matthew N. POY; Richard BEHRINGER; Sonia M. NAJJAR; Sue-Hwa LIN The intercellular adhesion molecule CEACAM1, also known as C-CAM1 (where CAM is cell-adhesion molecule), can function as a tumour suppressor in several carcinomas, including those of the prostate, breast...

.... 1 To whom correspondence should be addressed (e-mail [email protected] ). The Biochemical Society, London © 2001 2001 cell cycle dephosphorylation methylation PP2A tumour suppressor Biochem. J. (2001) 353, 417 439 (Printed in Great Britain) 417 REVIEW ARTICLE Protein...

... activation is sufficient to trigger PKCδ phosphorylation and that this signals through phosphoinositide 3-kinase (PI3-kinase) to stimulate the phosphorylation of two sites, T505 and S662. The loss of signal input to PKCδ in suspension culture is dependent on the tumour suppressor gene PTEN , which encodes...

... glycol-maleimide redox tumour suppressor nuclear accumulation Biochem. J. (2000) 351, 87 93 (Printed in Great Britain) 87 p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate : a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53...

...Nick R. LESLIE; Alex GRAY; Ian PASS; Elaine A. ORCHISTON; C. Peter DOWNES The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides, Shc, focal adhesion kinase and phosphoinositide substrates...