.... Fungal melanin is a major putative virulence factor of Mucorales fungi that allows intracellular persistence by inducing phagosome maturation arrest. Recently, it has been shown that the black pigments of Rhizopus delemar is of eumelanin type, that requires the involvement of tyrosinase (a copper...

...Hee-Young Park; Christina Wu; Laurie Yonemoto; Melissa Murphy-Smith; Heng Wu; Christina M. Stachur; Barbara A. Gilchrest The cAMP-dependent pathway up-regulates MITF (microphthalmia-associated transcription factor), important for key melanogenic proteins such as tyrosinase, TRP-1 (tyrosinase...

.... We have recently demonstrated that fatty acids, major components of cell membranes, are able to regulate the proteasomal degradation of tyrosinase, a critical enzyme required for melanin biosynthesis, in contrasting manners by relative increases or decreases in the ubiquitinated tyrosinase...

...Lorena G. FENOLL; María José PEÑALVER; José N. RODRÍGUEZ-LÓPEZ; P. A. GARCÍA-RUIZ; Francisco GARCÍA-CÁNOVAS; José TUDELA A solvent deuterium isotope effect on the catalytic affinity ( k m ) and catalytic constant ( k cat ) of tyrosinase in its action on different monophenols and o -diphenols...

... of the parent resveratrol on its enzymic oxidation were studied. Methyl and glucosyl derivatives were synthesized using simple one-step methodologies. The kinetics of their enzymic oxidation by tyrosinases were defined. Substitution at the p -hydroxy group, by either glucose or methyl, abolished enzymic...