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Keywords: tyrosine kinase
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Biochem J (2015) 472 (2): 195–204.
Published: 13 November 2015
... affinity-chromatography using an immobilized anti-phospho-(Tyr)-antibody, also increased the ligand-dependent tyrosine kinase activity of the isolated EGFR toward PGT. Also a CaM(Y99D/Y138D) mutant mimicked the effect of P-(Tyr)-CaM on ligand-dependent EGFR activation. Finally, we demonstrate that P-(Tyr...
Biochem J (2015) 469 (2): 199–210.
Published: 06 July 2015
... regulation of Ca 2+ -dependent protein-tyrosine phosphorylation. calcium G protein-coupled receptor (GPCR) platelets protein phosphorylation signal transduction tyrosine kinase thrombin The essential role of blood platelets in haemostasis and thrombosis relies on their ability to...
Biochem J (2015) 468 (3): 459–473.
Published: 15 June 2015
... 2015 Structurally diverse stimuli induce glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) activation but also activate other tyrosine kinase-linked receptors. This has pathophysiological significance in situations such as exposure to diesel exhaust particles (DEP) and elevation of...
Includes: Supplementary data
Biochem J (2015) 468 (2): 283–291.
Published: 22 May 2015
...Sonja Lorenz; Patricia Deng; Oliver Hantschel; Giulio Superti-Furga; John Kuriyan Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein kinase 1, Abl1) in the Bcr (breakpoint cluster region)–Abl1 fusion oncoprotein is the molecular cause of chronic...
Includes: Supplementary data
Biochem J (2013) 454 (2): 169–179.
Published: 09 August 2013
... transduction and regulation in all eukaryotic cells. The tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase) plays a crucial role in the T-cell response by transducing early activation signals triggered by TCR (T-cell receptor) engagement. These signals result in the phosphorylation of...
Includes: Multimedia, Supplementary data
Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial serine/threonine phosphorylation has been investigated in terms of the mitochondrial compartments in which it occurs, and the results of the mitochondrial serine/threonine phosphoproteome have previously been...
Includes: Supplementary data
Biochem J (2012) 447 (2): 313–320.
Published: 26 September 2012
...Shin-Ae Kang; Hyun-Soo Cho; Jong Bok Yoon; In Kwon Chung; Seung-Taek Lee PTK6 [protein tyrosine kinase 6; also known as Brk (breast tumour kinase)] is a non-receptor tyrosine kinase, closely related to Src, but evolutionarily distinct, that is up-regulated in various cancers, including breast...
Includes: Supplementary data
Biochem J (2010) 432 (2): 255–265.
Published: 12 November 2010
... Society 2010 acute leukaemia 4.1/ezrin/radixin/moesin (FERM) domain interferon-γ Janus kinase 1 (JAK1) transformation tyrosine kinase Members of the JAK (Janus kinase) family, JAK1, JAK2, JAK3 and Tyk2, play important roles in signalling downstream of cytokine receptor activation [ 1...
Biochem J (2009) 420 (2): 155–162.
Published: 13 May 2009
...Horacio Bach; Dennis Wong; Yossef Av-Gay In Mycobacterium tuberculosis , signal transduction is mediated by 11 serine/threonine kinases, but no tyrosine kinases have been identified thus far. The protein encoded by the ORF (open reading frame) Rv2232 has been annotated as a member of the HAD...
Includes: Supplementary data
Biochem J (2008) 416 (2): 189–199.
Published: 12 November 2008
...Annika C. Schüller; Zamal Ahmed; James A. Levitt; Kin M. Suen; Klaus Suhling; John E. Ladbury The adaptor protein Shc (Src homology and collagen-containing protein) plays an important role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) regulating diverse...
Biochem J (2008) 413 (1): 37–49.
Published: 12 June 2008
... receptor 2 (FGFR2) fibroblast growth factor receptor substrate 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase FGFRs [FGF (fibroblast growth factor) receptors] are receptor...
Biochem J (2008) 410 (3): e3–e4.
Published: 27 February 2008
...Michael D. Schaller Pyk2 (proline-rich tyrosine kinase 2) and FAK (focal adhesion kinase) are highly related tyrosine kinases. One distinguishing feature is the differential regulation of the two enzymes in response to elevation of cytoplasmic calcium. In the latest issue of the Biochemical Journal...
Biochem J (2007) 402 (2): 291–300.
Published: 12 February 2007
... resulted in phosphorylation of β-catenin on tyrosine residues, and abolished the interaction of β-catenin with E-cadherin by a tyrosine kinase-dependent mechanism. Protein binding studies showed that the treatment of cells with acetaldehyde reduced the binding of β-catenin to the C-terminal region of E...
Biochem J (2006) 397 (3): 537–543.
Published: 13 July 2006
...Kazuko Sakai; Hideyuki Yokote; Kimiko Murakami-Murofushi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported...
Biochem J (2005) 388 (2): 393–406.
Published: 24 May 2005
... protein kinases, have also been identified. Grb10 and Grb14 are widely, but not uniformly, expressed in mammalian tissues, and there are various isoforms of Grb10. Binding of Grb10 or Grb14 to autophosphorylated IR in vitro inhibits tyrosine kinase activity towards other substrates, but studies on...
Biochem J (2004) 382 (1): 199–204.
Published: 10 August 2004
...Wannian YANG; Jaclyn M. JANSEN; Qiong LIN; Sabrina CANOVA; Richard A. CERIONE; Chandra CHILDRESS ACK2 (activated Cdc42-associated tyrosine kinase 2) is a specific downstream effector for Cdc42, a member of the Rho family of small G-proteins. ACK2 interacts with clathrin, an endocytic vesicle...
Biochem J (2004) 377 (3): 569–578.
Published: 01 February 2004
...-R, but do not produce its intermediate isoform. Patch-clamp techniques showed that the application of 5 nM PRL increased both the macroscopic K + current amplitude and the single K + -channel open probability. This single-channel activity increase was reduced by the tyrosine kinase inhibitors...
Biochem J (2004) 377 (1): 249–255.
Published: 01 January 2004
...-chlorophenyl)-7-(t-butyl)pyrazolo[3,4- d ]pyrimidine (PP2), or a general protein tyrosine kinase inhibitor (genistein). GSK3β transfected into HEK-293 cells or Escherichia coli became phosphorylated at Tyr 216 , but catalytically inactive mutants did not. GSK3β expressed in insect Sf 21 cells or E. coli was...
Biochem J (2003) 372 (3): 897–903.
Published: 15 June 2003
...Laura CERCHIA; Domenico LIBRI; Maria Stella CARLOMAGNO; Vittorio de FRANCISCIS Substitution of Cys-634 in the extracellular domain of the Ret tyrosine kinase receptor causes its dimerization and activation of its transforming potential. To gain further insight into the molecular basis leading to...
Biochem J (2003) 371 (3): 907–915.
Published: 01 May 2003
... The Biochemical Society, London ©2003 2003 adapter lipid rafts signal transduction T lymphocytes tyrosine kinase Abbreviations used: Csk, C-terminal Src Kinase; DMEM, Dulbecco's modified Eagle's medium; FCS, foetal calf serum; ITAM, immunoreceptor tyrosine-based activation motif...
Biochem J (2003) 371 (2): 405–412.
Published: 15 April 2003
... correspondence should be addressed (e-mail tpillay@nottingham.ac.uk ). 10 10 2002 20 12 2002 9 1 2003 9 1 2003 The Biochemical Society, London ©2003 2003 Akt kinase c-Cbl tyrosine kinase Abbreviations used: APS, adapter protein with a PH and an SH2 domain; CHO...
Biochem J (2003) 371 (2): 485–493.
Published: 15 April 2003
...Takehito URUNO; Peijun ZHANG; Jiali LIU; Jian-Jiang HAO; Xi ZHAN HS1 (haematopoietic lineage cell-specific gene protein 1), a prominent substrate of intracellular protein tyrosine kinases in haematopoietic cells, is implicated in the immune response to extracellular stimuli and in cell...
Biochem J (2003) 370 (1): 29–34.
Published: 15 February 2003
... 2002 The Biochemical Society, London ©2003 2003 Abl ArgBP2 Cbl degradation tyrosine kinase ubiquitination Abbreviations used: Abl-KD, kinase-deficient Abl; Abl-SH2M, Abl SH2 domain mutant; ArgBP2, Arg-binding protein 2; Cbl-70Z, ubiquitin-ligase-deficient mutant of Cbl; CT, C...
Biochem J (2002) 368 (2): 471–481.
Published: 01 December 2002
... occludens (ZO)-1, E-cadherin and β-catenin. An oxidative-stress-induced decrease in transepithelial electrical resistance was associated with a redistribution of occludin—ZO-1 and E-cadherin—β-catenin complexes from the intercellular junctions. Genistein, a tyrosine kinase inhibitor, prevented the oxidative...
Biochem J (2002) 368 (1): 203–211.
Published: 15 November 2002
... 2 2002 17 6 2002 10 7 2002 10 7 2002 The Biochemical Society, London ©2002 2002 acute phase electrophoretic mobility-shift assay (EMSA) liver phosphorylation tyrosine kinase Abbreviations used: APR, acute phase response; ATF-2, activating transcription factor...
Biochem J (2002) 364 (2): 377–383.
Published: 01 June 2002
... ). 26 9 2001 21 1 2002 19 3 2002 The Biochemical Society, London ©2002 2002 protein–protein interaction signal transduction tyrosine kinase Abbreviations used: PTP, protein tyrosine phosphatase; PTK, protein tyrosine kinase; RPTK, receptor protein tyrosine kinase; SH2...
Biochem J (2002) 361 (1): 105–111.
Published: 17 December 2001
... behrmann@rwth-aachen.de ). 1 6 2001 27 9 2001 15 10 2001 The Biochemical Society, London ©2002 2002 box1/box2 region cytokine Jak association Jak/STAT tyrosine kinase Abbreviations used: EMSA, electrophoretic-mobility-shift assay; EPOR, erythropoietin receptor; Jak...
Biochem J (2000) 350 (3): 655–661.
Published: 08 September 2000
...-family tyrosine kinase inhibitor PP1, as well as specific inhibition of the epidermal growth factor receptor tyrosine kinase (EGFR TK) by PD153035, also blocks PYY stimulation of MAPK. This pathway further requires protein kinase C with EGFR TK inhibition blocking PYY-induced protein kinase Cε (PKCε...
Biochem J (2000) 347 (1): 61–67.
Published: 27 March 2000
... upstream of or at the level of the non-receptor tyrosine kinase, Src. Moreover, these experiments provide confirmation that the transfected human 5-HT 1A receptor induces the production of ROS (superoxide and hydrogen peroxide) in CHO cells, and support the possibility that an NAD(P)H oxidase-like enzyme...
Biochem J (2000) 345 (3): 759–766.
Published: 25 January 2000
...Kirsi PAUKKU; Sigrídur VALGEIRSDÓTTIR; Pipsa SAHARINEN; Mathias BERGMAN; Carl-Henrik HELDIN; Olli SILVENNOINEN Several growth factors activate signal transducers and activators of transcription (Stats) but the mechanism of Stat activation in receptor tyrosine kinase signalling has remained elusive...
Biochem J (1999) 341 (3): 665–668.
Published: 26 July 1999
...Zamal AHMED; Beverley J. SMITH; Kei KOTANI; Peter WILDEN; Tahir S. PILLAY APS (adapter protein with a PH and SH2 domain) is the newest member of a family of tyrosine kinase adapter proteins including SH2-B and Lnk. We previously identified SH2-B as an insulin-receptor-binding protein and substrate...
Biochem J (1999) 340 (2): 365–369.
Published: 25 May 1999
...-binding kinase α (ROKα)-, dependent pathway in EP3 receptor-expressing PC12 cells. Here we examined the involvement of tyrosine kinases in this pathway in nerve growth factor-differentiated PC12 cells. Tyrphostin A25, a tyrosine kinase inhibitor, blocked neurite retraction and cell rounding induced by...
Biochem J (1999) 339 (2): 413–418.
Published: 08 April 1999
... residues at its N-terminus and C-terminus is a powerful stimulus of platelet aggregation and secretion through the surface receptor glycoprotein VI (GPVI). The activation of platelets is associated with tyrosine phosphorylation of the tyrosine kinase Syk and phospholipase C γ2 (PLCγ2). We now report that...
Biochem J (1999) 338 (3): 677–680.
Published: 08 March 1999
...Sibaji SARKAR; Michael M. ROONEY; Susan T. LORD Published data suggest that the tyrosine kinase syk participates in platelet signalling through the integrin α IIb β 3 . Our data show an association of syk and integrin β 3 in immunoprecipitates from unstimulated and stimulated platelets. We detected...
Biochem J (1999) 337 (2): 185–192.
Published: 08 January 1999
... PLD activity induced by MSU. Erbstatin and ST-638, two inhibitors of tyrosine kinases, inhibited the MSU-induced translocation of Arf and PKCα but not MSU-induced tyrosine phosphorylation and PLD activation. Furthermore MSU crystals did not cause the tyrosine phosphorylation of PLD1. The present study...