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Keywords: tyrosine kinase inhibitor
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Articles
Nutlin-3 plus tanshinone IIA exhibits synergetic anti-leukemia effect with imatinib by reactivating p53 and inhibiting the AKT/mTOR pathway in Ph+ ALL
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (24): 4153–4170.
Published: 06 December 2017
...Yong Guo; Yi Li; Bing Xiang; Xiao-Ou Huang; Hong-Bing Ma; Fang-Fang Wang; Yu-Ping Gong Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is triggered by BCR/ABL kinase. Recent efforts focused on the development of more potent tyrosine kinase inhibitors (TKIs) that also inhibit...
Includes: Supplementary data
Articles
Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation
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Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 307–314.
Published: 10 January 2000
...Sudawadee SUTTITANAMONGKOL; Adrian R. L. GEAR; Renata POLANOWSKA-GRABOWSKA Geldanamycin (GA), a benzoquinoid ansamycin antibiotic, has been used as a tyrosine kinase inhibitor and an anti-tumour agent and is known to bind to heat-shock protein 90. In the present study on human platelets we have...
