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Keywords: tyrosine phosphorylation
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Biochem J (2019) 476 (15): 2239–2254.
Published: 15 August 2019
... important functions of acetylation in the regulation of protein function. Much less is known on how the acetyltransferases themselves are regulated. In the current study, we discover that the Elongator protein 3 (ELP3) acetyltransferase is modified by tyrosine phosphorylation. We demonstrate that the...
Includes: Supplementary data
Biochem J (2014) 459 (1): 15–25.
Published: 14 March 2014
... kinase assay protein–protein interaction tyrosine phosphorylation 14-3-3 proteins are a class of regulatory/effector proteins that modulate client protein function through phosphorylation-dependent associations [ 1 ]. The Arabidopsis genome encodes 15 different 14-3-3 isoforms, 13 of which...
Includes: Supplementary data
Biochem J (2012) 445 (2): 255–264.
Published: 27 June 2012
... growth factor receptor (EGFR) epidermal growth factor receptor (EGFR) binding growth-factor-receptor-bound protein 2 (Grb2) tyrosine phosphorylation ACK [activated Cdc42 (cell division cycle 42)-associated tyrosine kinase] [also called TNK2 (tyrosine kinase, non-receptor, 2)] was initially...
Includes: Supplementary data
Biochem J (2011) 439 (1): 151–159.
Published: 14 September 2011
...@gate.sinica.edu.tw ). Dock/Nck Drosophila insulin receptor insulin signalling protein tyrosine phosphatase 61F/protein tyrosine phosphatase 1B (PTP61F/PTP1B) tyrosine phosphorylation Insulin is a key anabolic hormone that promotes the storage of fuels as macromolecules. Insulin exerts its effects...
Includes: Supplementary data
Biochem J (2009) 418 (2): 359–367.
Published: 11 February 2009
... oxidant, induces disulfide cross-linking of poorly glycosylated band 3 and that the oligomerized band 3 fraction is selectively tyrosine phosphorylated both in G6PD (glucose-6-phosphate dehydrogenase)-deficient and control RBCs. This phenomenon is irreversible in G6PD-deficient RBCs, whereas it is...
Biochem J (2009) 417 (1): 277–285.
Published: 12 December 2008
... demonstrates that brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 in the rat hippocampus. PP2, a specific inhibitor of SrcPTKs (Src family protein tyrosine kinases), prevents the ischaemia-induced increases not only in the tyrosine phosphorylation of PSD-95, but also in the...
Biochem J (2008) 409 (1): 275–287.
Published: 11 December 2007
..., we show that of the 13 tyrosine residues resident in the cytosolic domain of TLR8, only three appear to be critical to TLR8 signalling. Two of these, Tyr 898 and Tyr 904 , reside in the Box 1 motif and the third, Tyr 1048 , lies in a YXXM putative p85-binding motif. TLR8 is tyrosine-phosphorylated...
Biochem J (2007) 402 (1): 1–15.
Published: 25 January 2007
... 2006 28 11 2006 29 11 2006 The Biochemical Society, London 2007 protein tyrosine phosphatase (PTP) substrate identification substrate-trapping tyrosine phosphorylation The cellular equilibrium of protein tyrosine phosphorylation is achieved through the actions of PTKs...
Biochem J (2006) 400 (1): 127–134.
Published: 27 October 2006
... A 2 analogue U46619 does not activate integrin αIIbβ3 or trigger platelet aggregation, but it induces shape changes. In the present study, we addressed whether low doses of U46619 trigger tyrosine phosphorylation independently of integrin αIIbβ3 activation and ADP secretion, and synergize with...
Biochem J (2006) 397 (2): 337–344.
Published: 28 June 2006
... fragment of the PDGFR-β, which has a truncation of its extracellular domain, accounted for approx. 15% of the total PDGFR-β detected in VSMCs with an antibody against its cytoplasmic domain. Stimulation of VSMCs with Ang II increased tyrosine-phosphorylation of p70 PDGFR-β at Tyr 751 and Tyr 1021 and...
Biochem J (2006) 394 (3): 693–698.
Published: 24 February 2006
... degradation of EGF (epidermal growth factor) receptor. In mapping the tyrosine phosphorylation region, we found that the C-terminus of SH3PX1 is required for its tyrosine phosphorylation. Further analysis indicates that this region, known as the coiled-coil domain or the BAR (Bin–amphiphysin–Rvs homology...
Biochem J (2006) 393 (2): 565–573.
Published: 23 December 2005
...Ramon Wade; Scott Vande Pol Tyrosine phosphorylation of FAK (focal adhesion kinase) regulates signalling that results from the interaction of integrins with extracellular matrix and growth factor receptors. A critical step in this process is the phosphorylation of Tyr 397 of FAK, which creates a...
Biochem J (2006) 393 (1): 351–359.
Published: 12 December 2005
..., DRM-disrupting agents, such as nystatin and methyl-β-cyclodextrin, alter cellular responses to CD16b receptor ligation. Notably, a significant increase in the mobilization of intracellular Ca 2+ and in tyrosine phosphorylation of intracellular substrates after CD16b engagement is observed. Altogether...
Biochem J (2005) 388 (2): 713–720.
Published: 24 May 2005
...Ingeborg HERS; Jeremy M. TAVARÉ Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K...
Biochem J (2004) 381 (3): 919–928.
Published: 27 July 2004
... difficulties, the early signalling steps in response to CD32A activation were studied in purified plasma membranes of neutrophils. After CD32A cross-linking in these fractions, the tyrosine phosphorylation of two major substrates, the receptor itself and the tyrosine kinase Syk, was observed. Phosphorylation...
Biochem J (2004) 380 (3): 767–774.
Published: 15 June 2004
... activated FGFRs was detected. RasGAP was a substrate of the activated FGFR kinase domain, and mutation of the tyrosine residue within the potential binding site on the receptor prevented tyrosine phosphorylation of RasGAP. RasGAP attenuated FGFR signalling in vivo and this ability was dependent on both its...
Biochem J (2004) 380 (1): 243–253.
Published: 15 May 2004
... receptor, c-Fms. After adding CSF-1 to M1 myeloid cells expressing CSF-1R (CSF-1 receptor), tyrosine phosphorylation of many cellular proteins occurs, which might be linked to subsequent macrophage differentiation. The biological significance and characterization of such proteins were explored by a dual...
Biochem J (2004) 380 (1): e7–e8.
Published: 15 May 2004
... organization of the actin cytoskeleton. 1 e-mail sgunst@iupui.edu 5 4 2004 14 4 2004 25 5 2004 The Biochemical Society, London ©2004 2004 actin cytoskeleton actin polymerization Arp2/3 complex Fyn/Fer kinases tyrosine phosphorylation Biochem. J. (2004) 380, e7 e8...
Biochem J (2004) 378 (1): 105–116.
Published: 15 February 2004
... substrate-1) tyrosine phosphorylation and phosphoinositide 3-kinase activation, although the mechanism(s) for this resistance is not known. In the present study, we have explored the possibility of a novel PKC, PKCδ, to modulate directly the ability of the insulin receptor kinase to tyrosine-phosphorylate...
Biochem J (2004) 377 (2): 517–524.
Published: 15 January 2004
... (Janus kinase 2)-mediated tyrosine phosphorylation of the receptor. Less than 1% of the EPO-Rs are displayed on the cell surface; most of the receptor molecules are retained in intracellular compartments, including the ER (endoplasmic reticulum). Using pervanadate (PV) as a potent tool to inhibit...
Biochem J (2004) 377 (2): 499–507.
Published: 15 January 2004
... tyrosine residue at position 298 of ephrinB1 as being required for the physical interaction with Grb4, whereas Tyr-305 and Tyr-310 are dispensable. Moreover, we show that the region between amino acids 301 and 304 of ephrinB1 is also required for this critical tyrosine-phosphorylation-dependent event...
Biochem J (2004) 377 (2): 289–297.
Published: 15 January 2004
...Antje K. KRETZSCHMAR; Michaela C. DINGER; Christian HENZE; Katja BROCKE-HEIDRICH; Friedemann HORN Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines...
Biochem J (2003) 374 (1): 269–280.
Published: 15 August 2003
... phospholipase activation phospholipase Cγ2 (PLCγ2) Src homology 2 domain (SH2 domain) tyrosine phosphorylation Abbreviations used: BCR, B-cell antigen receptor; BLNK, B-cell linker; EGF, epidermal growth factor; Fluo 3/AM, Fluo-3 acetoxymethyl ester; PH, pleckstrin homology; PHδ1PLCγ2, chimera of...
Biochem J (2003) 372 (3): 841–849.
Published: 15 June 2003
... stoichiometry approaching 2 mol phosphotyrosine/mol CK2α with a concomitant 3-fold increase in catalytic activity. We also show that endogenous CK2α becomes tyrosine-phosphorylated in pervanadate-treated Jurkat cells. Both tyrosine phosphorylation and stimulation of activity are suppressed by the specific Src...
Biochem J (2002) 368 (1): 49–56.
Published: 15 November 2002
... receptor substrate (IRS) family of docking proteins to the receptor is not known. Following incubation of mouse kidney proximal tubular epithelial cells with VEGF, we observed an increase in tyrosine phosphorylation of several proteins, including one of 200kDa, suggesting possible regulation of...
Biochem J (2002) 361 (2): 297–305.
Published: 08 January 2002
..., the Fc receptor (FcR) γ-chain and Syk, leading to tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2). The aim of the present study was to assess the functional significance of this pathway in platelet activation by GPIb-IX-V. In washed platelets, vWF/ristocetin and vWF/botrocetin stimulate weak...
Biochem J (2001) 360 (1): 239–245.
Published: 08 November 2001
... was absent from cells on FN120. Overall, tyrosine phosphorylation was much less in cell lysates from cells on FN120, with decreased phosphorylation of focal adhesion kinase (‘pp125FAK’) on tyrosine-397, implying additional regulation of tyrosine phosphorylation by HepII. Nevertheless, adhesion...
Biochem J (2001) 359 (3): 497–505.
Published: 25 October 2001
... should be addressed (e-mail walter.becker@post.rwth-aachen.de ). 8 5 2001 6 7 2001 31 8 2001 The Biochemical Society, London ©2001 2001 activation loop molecular model signal transduction tyrosine phosphorylation Abbreviations used: ERK, extracellular-signal...
Biochem J (2001) 356 (2): 461–471.
Published: 24 May 2001
...Pedro E. PAZ; Soujuan WANG; Holly CLARKE; Xaiobin LU; David STOKOE; Arie ABO T-cell-receptor (TCR)-mediated LAT (linker for activation of T cells) phosphorylation is critical for the membrane recruitment of signalling complexes required for T-cell activation. Although tyrosine phosphorylation of...
Biochem J (2001) 353 (3): 483–492.
Published: 25 January 2001
... 29 9 2000 1 11 2000 The Biochemical Society, London © 2001 2001 glycosylation inhibitory receptor sialic acid tyrosine phosphorylation Biochem. J. (2001) 353, 483 492 (Printed in Great Britain) 483 mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding...
Biochem J (2000) 350 (3): 925–932.
Published: 08 September 2000
... University College London Medical School, Department of Medicine, Upper third floor, Rowland Hill Street, London NW3 2PF, U.K. (e-mail g.skouteris@rfc.ucl.ac.uk ). 22 2 2000 22 6 2000 14 7 2000 The Biochemical Society, London © 2000 2000 tyrosine phosphorylation mitosis MET...
Biochem J (2000) 349 (2): 427–434.
Published: 10 July 2000
... STAT1 activation and tyrosine phosphorylation. The inhibitory effect of ethanol was not reversed by pretreatment with either sodium vanadate, a non-selective tyrosine phosphatase inhibitor, or with MG132, a specific proteasome inhibitor. This suggests that protein tyrosine phosphatases or the ubiquitin...
Biochem J (2000) 345 (3): 759–766.
Published: 25 January 2000
... binding of Stat5 to the receptor. Finally, fibroblasts derived from Src -/- and Fyn -/- mice showed normal pattern of PDGF-induced tyrosine phosphorylation of Stat5. Taken together, these results indicate that Stat5 is a direct substrate for PDGF β-R and that the activation does not require Jak1, Jak2, c...
Biochem J (2000) 345 (2): 217–224.
Published: 10 January 2000
..., indicating involvement of the PDGF receptor kinase in LPA-mediated signalling. This was confirmed by pertussis-toxin-sensitive tyrosine phosphorylation of the PDGF receptor by LPA, whereas no phosphorylation of the EGF receptor was detected. For comparison, 5-hydroxytryptamine (‘serotonin’)-mediated...
Biochem J (2000) 345 (2): 385–392.
Published: 10 January 2000
... form of the p85 subunit of PI-3K to block the activation of ERK2 by integrin. Stimulation of α4β1 integrins on HL60 cells also leads to increased tyrosine phosphorylation of the 120 kDa adaptor protein Cbl. PI-3K activity associated with Cbl also increases on the stimulation of α4β1 integrins, although...
Biochem J (1999) 344 (3): 649–658.
Published: 08 December 1999
... glucose- and rGH-stimulated INS-1 cell proliferation. Glucose (> 3 mM) independently increased tyrosine-phosphorylation-mediated recruitment of growth-factor-bound protein 2 (Grb2)/murine sons of sevenless-1 protein (mSOS) and PI3ʹK to insulin receptor substrate (IRS)-1 and IRS-2, as well as SH2...
Biochem J (1999) 343 (2): 335–340.
Published: 08 October 1999
... Vascular Biology Center address ( rvenema@mail.mcg.edu ). 7 6 1999 11 8 1999 The Biochemical Society, London © 1999 1999 angiotensin II ATP bradykinin endothelin-1 tyrosine phosphorylation Biochem. J. (1999) 343, 335 340 (Printed in Great Britain) 335 Endothelial nitric oxide...
Biochem J (1999) 342 (1): 231–238.
Published: 10 August 1999
... unaffected by the simultaneous presence of BSA. Regarding the JAK/STAT pathway, AGE (100 μ g/ml) induced tyrosine phosphorylation of JAK2 (but not JAK1, JAK3 or TYK2) at 15-60 min; it also induced the tyrosine phosphorylation of STAT1 and STAT3 at 1-2 h and 0.5-4 h respectively. Being a transcription factor...
Biochem J (1999) 341 (3): 665–668.
Published: 26 July 1999
... [Kotani, Wilden and Pillay (1998) Biochem J. 335 , 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158 and...
Biochem J (1999) 341 (1): 211–216.
Published: 24 June 1999
... adapter protein autophosphorylation Ras/MAP kinase pathway SH2 domain tyrosine phosphorylation Biochem. J. (1999) 341, 211 216 (Printed in Great Britain) 211 Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor Kerstin THO...
Biochem J (1999) 338 (1): 203–209.
Published: 08 February 1999
... Src-family kinases in this signalling pathway. The selective Src-family kinase inhibitor PP1 prevented collagen-stimulated increases in whole-cell tyrosine phosphorylation and tyrosine phosphorylation of the FcR γ chain and p72 syk . A similar set of observations was made for a collagen-related...
Biochem J (1999) 337 (2): 179–184.
Published: 08 January 1999
... also confirmed in HeLa cells by co-immunoprecipitation experiments. Inhibition of PTP-BAS by expression of dominant-negative PTP-BAS mutant resulted in tyrosine-phosphorylation of IκBα. Tyrosine-phosphorylation of IκBα is a key event in activation of nuclear factor (NF)-κB during reoxygenation. PTP-BAS...