Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-42 of 42
Keywords: tyrosine phosphorylation
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (15): 2239–2254.
Published: 15 August 2019
... important functions of acetylation in the regulation of protein function. Much less is known on how the acetyltransferases themselves are regulated. In the current study, we discover that the Elongator protein 3 (ELP3) acetyltransferase is modified by tyrosine phosphorylation. We demonstrate...
Includes: Supplementary data
Articles
Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 459 (1): 15–25.
Published: 14 March 2014
... in a specific manner. 14-3-3 protein Arabidopsis calcium-dependent protein kinase kinase assay protein–protein interaction tyrosine phosphorylation 14-3-3 proteins are a class of regulatory/effector proteins that modulate client protein function through phosphorylation-dependent...
Includes: Supplementary data
Articles
The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1)
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2012) 445 (2): 255–264.
Published: 27 June 2012
...) EGTA and washed three times with PBS. The suspended cells were incubated on the control (suspension) or the fibronectin-coated plates for 30 min. Both suspended and adhered cells were harvested and lysed. The tyrosine phosphorylation of ACK1 and its mutants was detected by immunoblotting with an anti...
Includes: Supplementary data
Articles
Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling
Available to PurchaseChia-Lun Wu, Bree Buszard, Chun-Hung Teng, Wei-Lin Chen, Coral G. Warr, Tony Tiganis, Tzu-Ching Meng
Journal:
Biochemical Journal
Biochem J (2011) 439 (1): 151–159.
Published: 14 September 2011
... receptor) substrate] proteins 1–4 [ 1 , 2 ]. Tyrosine phosphorylation of IRS scaffold proteins allows for the nucleation of signalling complexes and the activation of key pathways, including the PI3K (phosphatidylinositol 3-kinase)/Akt pathway that elicits many of insulin's metabolic and mitogenic effects...
Includes: Supplementary data
Articles
Oxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells
Available to PurchaseAntonella Pantaleo, Emanuela Ferru, Giuliana Giribaldi, Franca Mannu, Franco Carta, Alessandro Matte, Lucia de Franceschi, Franco Turrini
Journal:
Biochemical Journal
Biochem J (2009) 418 (2): 359–367.
Published: 11 February 2009
... oxidant, induces disulfide cross-linking of poorly glycosylated band 3 and that the oligomerized band 3 fraction is selectively tyrosine phosphorylated both in G6PD (glucose-6-phosphate dehydrogenase)-deficient and control RBCs. This phenomenon is irreversible in G6PD-deficient RBCs, whereas...
Articles
Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 417 (1): 277–285.
Published: 12 December 2008
... demonstrates that brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 in the rat hippocampus. PP2, a specific inhibitor of SrcPTKs (Src family protein tyrosine kinases), prevents the ischaemia-induced increases not only in the tyrosine phosphorylation of PSD-95, but also...
Articles
The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 275–287.
Published: 11 December 2007
..., we show that of the 13 tyrosine residues resident in the cytosolic domain of TLR8, only three appear to be critical to TLR8 signalling. Two of these, Tyr 898 and Tyr 904 , reside in the Box 1 motif and the third, Tyr 1048 , lies in a YXXM putative p85-binding motif. TLR8 is tyrosine-phosphorylated...
Articles
Protein tyrosine phosphatase function: the substrate perspective
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 1–15.
Published: 25 January 2007
... identification substrate-trapping tyrosine phosphorylation The cellular equilibrium of protein tyrosine phosphorylation is achieved through the actions of PTKs (protein tyrosine kinases) and PTPs (protein tyrosine phosphatases). The realization that disrupting the equilibrium of cellular tyrosine...
Articles
Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A 2 in human platelets
Available to PurchasePietro Minuz, Laura Fumagalli, Stefania Gaino, Rosa M. Tommasoli, Maurizio Degan, Chiara Cavallini, Anna Lecchi, Marco Cattaneo, Clara Lechi Santonastaso, Giorgio Berton
Journal:
Biochemical Journal
Biochem J (2006) 400 (1): 127–134.
Published: 27 October 2006
... A 2 analogue U46619 does not activate integrin αIIbβ3 or trigger platelet aggregation, but it induces shape changes. In the present study, we addressed whether low doses of U46619 trigger tyrosine phosphorylation independently of integrin αIIbβ3 activation and ADP secretion, and synergize...
Articles
Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-β and its binding to class IA PI3K in vascular smooth muscle cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 397 (2): 337–344.
Published: 28 June 2006
.... This fragment of the PDGFR-β, which has a truncation of its extracellular domain, accounted for approx. 15% of the total PDGFR-β detected in VSMCs with an antibody against its cytoplasmic domain. Stimulation of VSMCs with Ang II increased tyrosine-phosphorylation of p70 PDGFR-β at Tyr 751 and Tyr 1021...
Articles
Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 394 (3): 693–698.
Published: 24 February 2006
... the degradation of EGF (epidermal growth factor) receptor. In mapping the tyrosine phosphorylation region, we found that the C-terminus of SH3PX1 is required for its tyrosine phosphorylation. Further analysis indicates that this region, known as the coiled-coil domain or the BAR (Bin–amphiphysin–Rvs homology...
Articles
Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 393 (2): 565–573.
Published: 23 December 2005
...Ramon Wade; Scott Vande Pol Tyrosine phosphorylation of FAK (focal adhesion kinase) regulates signalling that results from the interaction of integrins with extracellular matrix and growth factor receptors. A critical step in this process is the phosphorylation of Tyr 397 of FAK, which creates...
Articles
CD16b associates with high-density, detergent-resistant membranes in human neutrophils
Available to PurchaseMaria J. G. Fernandes, Emmanuelle Rollet-Labelle, Guillaume Paré, Sébastien Marois, Marie-Lisane Tremblay, Jean-Luc Teillaud, Paul H. Naccache
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 351–359.
Published: 12 December 2005
..., DRM-disrupting agents, such as nystatin and methyl-β-cyclodextrin, alter cellular responses to CD16b receptor ligation. Notably, a significant increase in the mobilization of intracellular Ca 2+ and in tyrosine phosphorylation of intracellular substrates after CD16b engagement is observed. Altogether...
Articles
Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 713–720.
Published: 24 May 2005
...Ingeborg HERS; Jeremy M. TAVARÉ Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K...
Articles
Recruitment of the cross-linked opsonic receptor CD32A (FcγRIIA) to high-density detergent-resistant membrane domains in human neutrophils
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 919–928.
Published: 27 July 2004
... difficulties, the early signalling steps in response to CD32A activation were studied in purified plasma membranes of neutrophils. After CD32A cross-linking in these fractions, the tyrosine phosphorylation of two major substrates, the receptor itself and the tyrosine kinase Syk, was observed. Phosphorylation...
Articles
p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 380 (3): 767–774.
Published: 15 June 2004
...) and the activated FGFRs was detected. RasGAP was a substrate of the activated FGFR kinase domain, and mutation of the tyrosine residue within the potential binding site on the receptor prevented tyrosine phosphorylation of RasGAP. RasGAP attenuated FGFR signalling in vivo and this ability was dependent on both its...
Articles
A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling
Available to PurchaseMaddalena CROSS, Xavier F. CSAR, Nicholas J. WILSON, Gaël MANES, Theresa A. ADDONA, Denese C. MARKS, Genevieve A. WHITTY, Keith ASHMAN, John A. HAMILTON
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): 243–253.
Published: 15 May 2004
... receptor, c-Fms. After adding CSF-1 to M1 myeloid cells expressing CSF-1R (CSF-1 receptor), tyrosine phosphorylation of many cellular proteins occurs, which might be linked to subsequent macrophage differentiation. The biological significance and characterization of such proteins were explored by a dual...
Articles
Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): e7–e8.
Published: 15 May 2004
... organization of the actin cytoskeleton. 1 e-mail [email protected] 5 4 2004 14 4 2004 25 5 2004 The Biochemical Society, London ©2004 2004 actin cytoskeleton actin polymerization Arp2/3 complex Fyn/Fer kinases tyrosine phosphorylation Biochem. J. (2004) 380, e7 e8...
Articles
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 105–116.
Published: 15 February 2004
... substrate-1) tyrosine phosphorylation and phosphoinositide 3-kinase activation, although the mechanism(s) for this resistance is not known. In the present study, we have explored the possibility of a novel PKC, PKCδ, to modulate directly the ability of the insulin receptor kinase to tyrosine-phosphorylate...
Articles
Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 517–524.
Published: 15 January 2004
... (Janus kinase 2)-mediated tyrosine phosphorylation of the receptor. Less than 1% of the EPO-Rs are displayed on the cell surface; most of the receptor molecules are retained in intracellular compartments, including the ER (endoplasmic reticulum). Using pervanadate (PV) as a potent tool to inhibit...
Articles
Tyr-298 in ephrinB1 is critical for an interaction with the Grb4 adaptor protein
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 499–507.
Published: 15 January 2004
... the tyrosine residue at position 298 of ephrinB1 as being required for the physical interaction with Grb4, whereas Tyr-305 and Tyr-310 are dispensable. Moreover, we show that the region between amino acids 301 and 304 of ephrinB1 is also required for this critical tyrosine-phosphorylation-dependent event...
Articles
Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 289–297.
Published: 15 January 2004
...Antje K. KRETZSCHMAR; Michaela C. DINGER; Christian HENZE; Katja BROCKE-HEIDRICH; Friedemann HORN Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines...
Articles
Requirements for distinct steps of phospholipase Cγ2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2003) 374 (1): 269–280.
Published: 15 August 2003
... activation phospholipase Cγ2 (PLCγ2) Src homology 2 domain (SH2 domain) tyrosine phosphorylation Abbreviations used: BCR, B-cell antigen receptor; BLNK, B-cell linker; EGF, epidermal growth factor; Fluo 3/AM, Fluo-3 acetoxymethyl ester; PH, pleckstrin homology; PHδ1PLCγ2, chimera of PLCγ2...
Articles
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity
Available to PurchaseArianna DONELLA-DEANA, Luca CESARO, Stefania SARNO, Maria RUZZENE, Anna Maria BRUNATI, Oriano MARIN, Greg VILK, Amanda DOHERTY-KIRBY, Gilles LAJOIE, David W. LITCHFIELD, Lorenzo A. PINNA
Journal:
Biochemical Journal
Biochem J (2003) 372 (3): 841–849.
Published: 15 June 2003
... to a stoichiometry approaching 2 mol phosphotyrosine/mol CK2α with a concomitant 3-fold increase in catalytic activity. We also show that endogenous CK2α becomes tyrosine-phosphorylated in pervanadate-treated Jurkat cells. Both tyrosine phosphorylation and stimulation of activity are suppressed by the specific Src...
Articles
The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 49–56.
Published: 15 November 2002
... receptor substrate (IRS) family of docking proteins to the receptor is not known. Following incubation of mouse kidney proximal tubular epithelial cells with VEGF, we observed an increase in tyrosine phosphorylation of several proteins, including one of 200kDa, suggesting possible regulation...
Articles
Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibα is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway
Available to PurchaseStuart J. MARSHALL, Naoki ASAZUMA, Denise BEST, Peter WONEROW, Gary SALMON, Robert K. ANDREWS, Steve P. WATSON
Journal:
Biochemical Journal
Biochem J (2002) 361 (2): 297–305.
Published: 08 January 2002
..., the Fc receptor (FcR) γ-chain and Syk, leading to tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2). The aim of the present study was to assess the functional significance of this pathway in platelet activation by GPIb-IX-V. In washed platelets, vWF/ristocetin and vWF/botrocetin stimulate weak...
Articles
C-terminal heparin-binding domain of fibronectin regulates integrin-mediated cell spreading but not the activation of mitogen-activated protein kinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 239–245.
Published: 08 November 2001
... but was absent from cells on FN120. Overall, tyrosine phosphorylation was much less in cell lysates from cells on FN120, with decreased phosphorylation of focal adhesion kinase (‘pp125FAK’) on tyrosine-397, implying additional regulation of tyrosine phosphorylation by HepII. Nevertheless, adhesion-mediated MAPK...
Articles
Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A
Available to PurchaseSunke HIMPEL, Pascal PANZER, Klaus EIRMBTER, Hanna CZAJKOWSKA, Muhammed SAYED, Len C. PACKMAN, Tom BLUNDELL, Heiner KENTRUP, Joachim GRÖTZINGER, Hans-G. JOOST, Walter BECKER
Journal:
Biochemical Journal
Biochem J (2001) 359 (3): 497–505.
Published: 25 October 2001
... of DYRK1A is dependent on the autophosphorylation of a conserved tyrosine residue in the activation loop. 8 5 2001 6 7 2001 31 8 2001 The Biochemical Society, London ©2001 2001 activation loop molecular model signal transduction tyrosine phosphorylation Abbreviations...
Articles
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 356 (2): 461–471.
Published: 24 May 2001
...Pedro E. PAZ; Soujuan WANG; Holly CLARKE; Xaiobin LU; David STOKOE; Arie ABO T-cell-receptor (TCR)-mediated LAT (linker for activation of T cells) phosphorylation is critical for the membrane recruitment of signalling complexes required for T-cell activation. Although tyrosine phosphorylation...
Articles
mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 353 (3): 483–492.
Published: 25 January 2001
... 1 11 2000 The Biochemical Society, London © 2001 2001 glycosylation inhibitory receptor sialic acid tyrosine phosphorylation Biochem. J. (2001) 353, 483 492 (Printed in Great Britain) 483 mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin...
Articles
The β-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 925–932.
Published: 08 September 2000
... and University College London Medical School, Department of Medicine, Upper third floor, Rowland Hill Street, London NW3 2PF, U.K. (e-mail [email protected] ). 22 2 2000 22 6 2000 14 7 2000 The Biochemical Society, London © 2000 2000 tyrosine phosphorylation mitosis MET...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 349 (2): 427–434.
Published: 10 July 2000
... STAT1 activation and tyrosine phosphorylation. The inhibitory effect of ethanol was not reversed by pretreatment with either sodium vanadate, a non-selective tyrosine phosphatase inhibitor, or with MG132, a specific proteasome inhibitor. This suggests that protein tyrosine phosphatases or the ubiquitin...
Articles
Kirsi PAUKKU, Sigrídur VALGEIRSDÓTTIR, Pipsa SAHARINEN, Mathias BERGMAN, Carl-Henrik HELDIN, Olli SILVENNOINEN
Journal:
Biochemical Journal
Biochem J (2000) 345 (3): 759–766.
Published: 25 January 2000
... to the receptor. Finally, fibroblasts derived from Src -/- and Fyn -/- mice showed normal pattern of PDGF-induced tyrosine phosphorylation of Stat5. Taken together, these results indicate that Stat5 is a direct substrate for PDGF β-R and that the activation does not require Jak1, Jak2, c-Src or Fyn tyrosine...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 217–224.
Published: 10 January 2000
..., indicating involvement of the PDGF receptor kinase in LPA-mediated signalling. This was confirmed by pertussis-toxin-sensitive tyrosine phosphorylation of the PDGF receptor by LPA, whereas no phosphorylation of the EGF receptor was detected. For comparison, 5-hydroxytryptamine (‘serotonin’)-mediated...
Articles
Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the α4β1 integrin to mitogen-activated protein kinase signalling
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 385–392.
Published: 10 January 2000
... form of the p85 subunit of PI-3K to block the activation of ERK2 by integrin. Stimulation of α4β1 integrins on HL60 cells also leads to increased tyrosine phosphorylation of the 120 kDa adaptor protein Cbl. PI-3K activity associated with Cbl also increases on the stimulation of α4β1 integrins, although...
Articles
Sharon P. COUSIN, Sigrun R. HülGL, JR. Martin G. MYERS, Morris F. WHITE, Anne REIFEL-MILLER, Christopher J. RHODES
Journal:
Biochemical Journal
Biochem J (1999) 344 (3): 649–658.
Published: 08 December 1999
... glucose- and rGH-stimulated INS-1 cell proliferation. Glucose (> 3 mM) independently increased tyrosine-phosphorylation-mediated recruitment of growth-factor-bound protein 2 (Grb2)/murine sons of sevenless-1 protein (mSOS) and PI3ʹK to insulin receptor substrate (IRS)-1 and IRS-2, as well as SH2...
Articles
Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
Available to PurchaseMario B. MARRERO, Virginia J. VENEMA, Hong JU, Han HE, Haiying LIANG, Ruth B. CALDWELL, Richard C. VENEMA
Journal:
Biochemical Journal
Biochem J (1999) 343 (2): 335–340.
Published: 08 October 1999
... tyrosine phosphorylation Biochem. J. (1999) 343, 335 340 (Printed in Great Britain) 335 Endothelial nitric oxide synthase interactions with G-protein-coupled receptors Mario B. MARRERO Virginia J. VENEMA*, Hong JU*, Han HE*, Haiying LIANG*, Ruth B. CALDWELL and Richard C. VENEMA*s1 * Vascular Biology...
Articles
Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells
Available to PurchaseJau-Shyang HUANG, Jinn-Yuh GUH, Wen-Chun HUNG, Mei-Li YANG, Yung-Hsiung LAI, Hung-Chun CHEN, Lea-Yea CHUANG
Journal:
Biochemical Journal
Biochem J (1999) 342 (1): 231–238.
Published: 10 August 1999
... by the simultaneous presence of BSA. Regarding the JAK/STAT pathway, AGE (100 μ g/ml) induced tyrosine phosphorylation of JAK2 (but not JAK1, JAK3 or TYK2) at 15-60 min; it also induced the tyrosine phosphorylation of STAT1 and STAT3 at 1-2 h and 0.5-4 h respectively. Being a transcription factor, AGE also increased...
Articles
APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 341 (3): 665–668.
Published: 26 July 1999
... [Kotani, Wilden and Pillay (1998) Biochem J. 335 , 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158...
Articles
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 341 (1): 211–216.
Published: 24 June 1999
... adapter protein autophosphorylation Ras/MAP kinase pathway SH2 domain tyrosine phosphorylation Biochem. J. (1999) 341, 211 216 (Printed in Great Britain) 211 Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor Kerstin THO...
Articles
Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 338 (1): 203–209.
Published: 08 February 1999
... Src-family kinases in this signalling pathway. The selective Src-family kinase inhibitor PP1 prevented collagen-stimulated increases in whole-cell tyrosine phosphorylation and tyrosine phosphorylation of the FcR γ chain and p72 syk . A similar set of observations was made for a collagen-related...
Articles
Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IκBα through interaction between the PDZ1 domain and ankyrin repeats
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 337 (2): 179–184.
Published: 08 January 1999
... confirmed in HeLa cells by co-immunoprecipitation experiments. Inhibition of PTP-BAS by expression of dominant-negative PTP-BAS mutant resulted in tyrosine-phosphorylation of IκBα. Tyrosine-phosphorylation of IκBα is a key event in activation of nuclear factor (NF)-κB during reoxygenation. PTP-BAS may thus...
