...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. autophagy herpesvirus ubiquitin protease ubiquitin-proteasome system Cells were harvested 48 h after transfection, resuspended in PBS (Biowest, X0515-500) containing protease inhibitor cocktail...

... of the Biochemical Society 2017 cytokine receptors phosphorylation/dephosphorylation ubiquitin-proteasome system Human IFNGR1 in a pLX304 backbone was ordered from the plasmid repository, DNASU. IFNGR1 mutants were created using the QuickChange site-directed mutagenesis kits (Agilent). Constructs...

...Ian Collins; Hannah Wang; John J. Caldwell; Raj Chopra Manipulation of the ubiquitin–proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer and other diseases...

... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 ENaC endoplasmic reticulum-associated degradation (ERAD) Lhs1/GRP170 molecular chaperones ubiquitin–proteasome system Endoplasmic reticulum-associated degradation (ERAD) targets...

... and nerve injury, such as traumatic muscle denervation. The ubiquitin–proteasome system (UPS) is the predominant proteolytic machinery responsible for atrophy of skeletal muscle, and Nedd4-1 (neural precursor cell-expressed developmentally down-regulated 4-1) is one of a series of E3 ubiquitin ligases...

.... endoplasmic-reticulum-associated degradation (ERAD) MAPK-activated protein (MAPKAP) kinase-2 p38 tumour necrosis factor (TNF) Ube2j1 ubiquitin–proteasome system 1 To whom correspondence should be addressed (email [email protected] ). 7 6 2013 20 8 2013 11 9 2013...

...Anke Hofmeister-Brix; Sigurd Lenzen; Simone Baltrusch The ubiquitin–proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus/secretion cascade seem to be affected...

... receptor 26S proteasome transcriptional cross-talk ubiquitin–proteasome system The UPS (ubiquitin–proteasome system) is the major proteolytic route responsible for the controlled intracellular degradation of short-lived and misfolded proteins. The substrate selection, which is the first critical...

... for degradation through the ubiquitin–proteasome system [ 5 – 8 ]. Currently, there are three well-documented upstream signalling cascades that regulate the expression of atrogin-1 and MuRF1 during cancer cachexia [ 1 , 9 , 10 ]. First, reduced signalling through the IGF-I (insulin-like growth factor 1)/PI3K...

... (email [email protected] ). 16 6 2010 24 9 2010 5 10 2010 5 10 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 aging free radical hormesis protein degradation protein oxidation ubiquitin–proteasome system Oxidatively damaged proteins...

... polyubiquitination protein stability ubiquitin–proteasome system Xenopus neuronal differentiation One of the major pathways for degrading cellular proteins is the UPS (ubiquitin–proteasome system; reviewed in [ 7 ]). This form of regulated protein destruction requires the covalent attachment...