... 4.0 17 01 2025 25 03 2025 * Corresponding Author; email: ( [email protected] ), Pennsylvania, United States of America, US * Corresponding Author; email: ( [email protected] ), Leeds, United Kingdom of Great Britain and Northern Ireland, GB SPOP MyD88 Ubiquitin ligases...

...Anil Kumar Singh; Vishal Upadhyay; Arppita Sethi; Sangita Chowdhury; Shivkant Mishra; Shailendra Prasad Verma; Madan Lal Brahma Bhatt; Arun Kumar Trivedi E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological processes; however, its role in myeloid differentiation...

... residues. However, several ubiquitin ligases (E3s) have recently been identified that ubiquitylate proteins on non-Lys residues. For instance, HOIL-1 belongs to the RING-in-between RING (RBR) class of E3s and has an established role in Ser ubiquitylation. Given the homology between HOIL-1 and ARIH1, an RBR...

... receptors ubiquitin ligases ubiquitins The linear ubiquitin assembly complex (LUBAC) contains two different E3 ubiquitin ligases, HOIL-1 (haem-oxidised IRP2 ubiquitin ligase-1), also called RBCK1 (RING-B-box-coiled-coil protein interacting with PKC 1), and HOIP (HOIL-1-interacting protein). HOIP...

... patients. KSHV utilizes two viral E3 ubiquitin ligases, K3 and K5, in KSHV-infected cells to mediate the polyubiquitination-dependent down-regulation of several host membrane proteins involved in the immune system. Although K3 and K5 are members of the same family and have similar structural topologies, K3...

... structure protein–protein interactions ubiquitin ubiquitin ligases Parkinson's disease (PD) affects ∼1% of the world's population [ 1 ]. Though age of onset and disease severity can vary greatly among patients, there is increasing evidence that implicates mitochondrial dysfunction as a major...

... for this article was enabled by the participation of University of Oxford in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. crystallography degron hypertension mutation protein-serine-threonine kinases ubiquitin...

... for these modifications are therefore potential targets for therapeutic intervention. DTX3L is an E3 Ubiquitin ligase that forms a heterodimer with PARP9. In addition to its ubiquitin ligase activity, DTX3L–PARP9 also acts as an ADP-ribosyl transferase for Gly 76 on the C-terminus of ubiquitin. NAD + -dependent ADP...

... on behalf of the Biochemical Society 2021 BARD1 BRCA1 ubiquitin ligases ubiquitin signaling ubiquitins Table 1. Characterized BRCA1/BARD1 substrates. Substrate Biological function(s) a Observed in cells/ in vitro ? BRCA1 (BC)/BARD1 (BD) binding site Substrate Ub...

... E3 ubiquitin ligase MARCH2. MARCH2 is a member of a family of membrane-bound E3 ubiquitin ligases that target cell surface receptors for degradation. MARCH2 overexpressing M1 clones retained responsiveness to the related cytokines leukemia inhibitory factor and oncostatin M and we showed that its...

...Shisako Shoji; Kazuharu Hanada; Noboru Ohsawa; Mikako Shirouzu Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP...

... ubiquitin ubiquitin ligases Approximately a century ago, Friedrich Lewy made a key discovery towards the understanding of Parkinson's disease (PD) by identifying and describing large cytoplasmic proteinacious inclusions in brains of patients who had died with the disease [ 1 ]. These inclusions...

... the use of larger bifunctional molecules consisting of distinct substrate-binding and E3 ligase-binding groups conjugated by a linker; as first demonstrated for the recruitment of the Skp1–CUL–F-box complex containing Hrt1 (SCF) ubiquitin ligase to degrade methionine aminopeptidase-2 (MetAP-2) [ 61...

...-in to be used in the MD simulations. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 allosteric regulation Nedd8 polyubiquitination ubiquitin ligases Covalent ligation of ubiquitin to substrates and ubiquitins is achieved via a three...

... by Portland Press Limited on behalf of the Biochemical Society 2017 molecular chaperone post-translational modification proteasome protein quality control ubiquitin ligases Correspondence: Jeffrey L. Brodsky ( [email protected] ) Among these many ligases, three classes of E3s function...

... with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCF Fbxo7/PARK15 ubiquitin ligase activity are mechanistically linked to early-onset PD. To date...

... multiple neuropathologies [ 1 ]. axon neurites ubiquitin C-terminal hydrolase L1 (UCH-L1) ubiquitin ligases ubiquitin proteasome system 1 To whom correspondence should be addressed (email [email protected] ). 7 2 2016 25 4 2016 29 4 2016 UCH-L1 has...