... Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. deubiquitinase neurodegeneration polyglutamine repeat spinocerebellar ataxia type-3 ubiquitin proteasome system The human ATXN3 gene is located on chromosome...

... 6 6 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 argonaute autophagy N domain regulated proteolysis ubiquitin proteasome system ARGONAUTE (AGO) proteins are the central protein components of RNA Induced Silencing...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ERK inhibitors extracellular signal-regulated kinases MEK RAF RAS ubiquitin proteasome system The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway drives cell survival, cell proliferation...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cellular targeting endoplasmic reticulum ERAD molecular chaperones protein conformation ubiquitin proteasome system The regulation of salt and fluid balance across membranes is an essential...

... of the Biochemical Society 2021 herpesvirus post-translational modification UBE1 ubiquitin proteasome system ubiquitins virus replication Herpes simplex virus 1 (HSV-1) is a human DNA virus and a member of the neurotrophic Alphaherpesvirinae subfamily. HSV-1 causes a variety of diseases...

..., including facilitating degradation of substrates through the ubiquitin–proteasome system (UPS), autophagy, and endoplasmic-reticulum-associated protein degradation (ERAD) pathways. In addition, UBQLNs engage with chaperones to sequester, degrade, or assist repair of misfolded client proteins. Furthermore...

... ubiquitin proteasome system Ribavirin (RBV) is a synthetic guanosine analogue and has been used as an anti-viral drug, specifically for patients with chronic hepatitis C. Numerous direct-acting antivirals (DAAs) have also been developed and approved for the treatment of chronic hepatitis C patients...

...Jordan J.S. VerPlank; Alfred L. Goldberg The ubiquitin proteasome system degrades the great majority of proteins in mammalian cells. Countless studies have described how ubiquitination promotes the selective degradation of different cell proteins. However, there is a small but growing literature...

... multiple neuropathologies [ 1 ]. axon neurites ubiquitin C-terminal hydrolase L1 (UCH-L1) ubiquitin ligases ubiquitin proteasome system 1 To whom correspondence should be addressed (email [email protected] ). 7 2 2016 25 4 2016 29 4 2016 UCH-L1 has...