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Keywords: ubiquitination
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Articles
Anil Kumar Singh, Vishal Upadhyay, Arppita Sethi, Sangita Chowdhury, Shivkant Mishra, Shailendra Prasad Verma, Madan Lal Brahma Bhatt, Arun Kumar Trivedi
Journal:
Biochemical Journal
Biochem J (2024) 481 (10): 653–666.
Published: 10 May 2024
...Anil Kumar Singh; Vishal Upadhyay; Arppita Sethi; Sangita Chowdhury; Shivkant Mishra; Shailendra Prasad Verma; Madan Lal Brahma Bhatt; Arun Kumar Trivedi E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological processes; however, its role in myeloid differentiation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2023) 480 (20): 1659–1674.
Published: 19 October 2023
...-proteomics revealed over 1000 potential mechanosensing TAFs and UBE2A/B (Ubiquitin-conjugating enzyme E2 A) was experimentally identified as a force- and CI-dependent nucleocytoplasmic shuttling TAF. We found that translocation of YAP/TAZ and UBE2A/B are distinctively regulated by inhibition of myosin...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (22): 2379–2394.
Published: 30 November 2022
... been shown to be regulated primarily through phosphorylation and ubiquitination during various stages of the cell cycle. Although phosphorylation and ubiquitin-dependent proteasomal degradation of p21 have been well established, other post-translational modifications that contribute to regulation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2179–2199.
Published: 18 June 2021
... and has previously been shown to have a regulatory role in proteasome activity and assembly. Here, we report the association of the E3 ubiquitin ligase FBXO7-SCF (SKP1, cullin-1, F-box protein) with the BAG6 complex, consisting of the subunits BAG6, GET4 and UBL4A. We identify the subunit GET4 as a direct...
Articles
Yushuang Hu, Xuemei Bai, Chi Zhang, Susmita Chakrabarti, Bo Tang, Hongbo Xiong, Zhijie Wang, Gang Yu, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang
Journal:
Biochemical Journal
Biochem J (2020) 477 (9): 1683–1700.
Published: 11 May 2020
...Yushuang Hu; Xuemei Bai; Chi Zhang; Susmita Chakrabarti; Bo Tang; Hongbo Xiong; Zhijie Wang; Gang Yu; Chengqi Xu; Qiuyun Chen; Qing Kenneth Wang Cardiac sodium channel Na v 1.5 is associated with cardiac arrhythmias and heart failure. Protein ubiquitination is catalyzed by an E1–E2–E3 cascade...
Articles
Yuanya Zhang, Xiahe Huang, Jinlong Wang, Xiaorong Wang, Xiaofei Liu, Yuhang Chen, Wu Xu, Yingchun Wang
Journal:
Biochemical Journal
Biochem J (2019) 476 (13): 1911–1926.
Published: 02 July 2019
... of the conserved H-bond between Y210 and E237 of ERK1 through point mutation at or naturally occurring nitration on Y210 initiates a quality control program dependent on chaperon systems and CHIP (C-terminal of Hsp70-interacting protein)-mediated ubiquitination and degradation. The H-bond is also important...
Includes: Supplementary data
Articles
Daniel M. Pinkas, Caroline E. Sanvitale, Joshua C. Bufton, Fiona J. Sorrell, Nicolae Solcan, Rod Chalk, James Doutch, Alex N. Bullock
Journal:
Biochemical Journal
Biochem J (2017) 474 (22): 3747–3761.
Published: 01 November 2017
... interaction ubiquitination The human KCTD family contains 25 soluble proteins that share a conserved potassium ( K + ) C hannel T etramerization D omain (a subtype of ‘BTB domain’) at their N-termini and have variable C-termini [ 1 ]. The core BTB fold (named after homologous regions...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (10): 1297–1314.
Published: 11 May 2016
...Mathew Stanley; Satpal Virdee The modification of proteins with ubiquitin (Ub) is an important regulator of eukaryotic biology and deleterious perturbation of this process is widely linked to the onset of various diseases. The regulatory capacity of the Ub signal is high and, in part, arises from...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (5): 571–580.
Published: 24 February 2016
... there being no change in either the levels or the translation of their mRNAs. Instead, these subunits are targeted for degradation by the ubiquitin–proteasome system. The data allow us to propose a model for the formation of stoichiometric eIF2B complexes which can ensure their stoichiometric incorporation...
Includes: Supplementary data
Articles
Ximing Du, Yuxi Zhang, Sae Rom Jo, Xiaoyun Liu, Yanfei Qi, Brenna Osborne, Frances L. Byrne, Greg C. Smith, Nigel Turner, Kyle L. Hoehn, Andrew J. Brown, Hongyuan Yang
Journal:
Biochemical Journal
Biochem J (2015) 471 (2): 243–253.
Published: 02 October 2015
... by cholesterol accumulation in late endosomes (LE) and lysosomes (Ly). Nascent or mutated NPC1 is degraded through the ubiquitin–proteasome pathway, but how NPC1 degradation is regulated remains currently unknown. In the present study, we demonstrated a link between NPC1 degradation and the Akt (protein kinase B...
Includes: Supplementary data
Articles
Shanshan Qiao, Weiwei Guo, Lujian Liao, Lin Wang, Zheng Wang, Rui Zhang, Daqian Xu, Yuxue Zhang, Yi Pan, Zhenzhen Wang, Yan Chen
Journal:
Biochemical Journal
Biochem J (2015) 469 (3): 469–480.
Published: 23 July 2015
... via an ubiquitin ligase complex together with DDB1 and CUL4A (cullin 4A). PAQR3 (progestin and adipoQ receptor family member III) is a newly discovered tumour suppressor that is implicated in the development of many types of human cancers. In the present paper, we report that DDB2 is involved...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 467 (3): 365–386.
Published: 17 April 2015
...Emil Bulatov; Alessio Ciulli In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin–RING...
Includes: Supplementary data
Articles
Samira Zouhir, Joaquín Bernal-Bayard, Mar Cordero-Alba, Elena Cardenal-Muñoz, Beatriz Guimaraes, Noureddine Lazar, Francisco Ramos-Morales, Sylvie Nessler
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 135–144.
Published: 23 October 2014
... of them secrete the SlrP protein acting as E3 ubiquitin ligase in human host cells where it targets Trx1 (thioredoxin-1). SlrP belongs to the NEL family of bacterial E3 ubiquitin ligases that have been observed in two distinct autoinhibitory conformations. We solved the 3D structure of the SlrP–Trx1...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (1): e1–e2.
Published: 08 September 2014
... compilation © 2014 Biochemical Society 2014 inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) phosphorylation ubiquitination Protein kinases often require the phosphorylation of two amino acid residues...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 461 (3): 435–442.
Published: 10 July 2014
... at the post-translational level by accelerated cholesterol-dependent ubiquitination and proteasomal degradation, which is associated with the accumulation of squalene. Using model cell systems, we report that SM is stabilized by unsaturated fatty acids. Treatment with unsaturated fatty acids such as oleate...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 461 (1): 137–146.
Published: 13 June 2014
...) mitochondrion necrosis oxidative stress p53 ubiquitination Cells cultured on coverslips were washed with ice-cold PBS and then incubated with 5 μM MitoSOX™ Red (Invitrogen), a mitochondrial superoxide indicator, for 10 min at 37°C. To measure the MMP in cultures, the cells were incubated with 10 μM...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 301–312.
Published: 28 March 2014
... (SLC10A1), OSTα (SLC51A) and ABCG1 (ATP-binding cassette G1), remained unaffected. ASBT inhibition by RSV was reversed by proteasome inhibitors (MG-132 and lactacystin) and the ubiquitin inhibitor LDN57444, suggesting involvement of the ubiquitin–proteasome pathway. Immunoprecipitation revealed high levels...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (1): 193–203.
Published: 14 March 2014
... enzymes. To date, little is known about the upstream regulation of hPXR. Using MS analysis and a kinome-wide siRNA screen, we report that the E3 ligase UBR5 (ubiquitin protein ligase E3 component n-recognin 5) and DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) regulate hPXR stability...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (3): 421–437.
Published: 28 February 2014
...Donald E. Spratt; Helen Walden; Gary S. Shaw The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. This unique family of E3 ligases includes parkin, whose dysfunction is linked...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (3): 537–545.
Published: 28 February 2014
... ubiquitination of p21 in a reconstituted in vitro system where UbcH5a is the preferred E2. Thus the ability of TRIM3 to suppress growth is associated with its ability to ubiquitinate proteins. The present study demonstrates that growth suppression by TRIM3, a bona fide tumour suppressor, is RING-dependent...
Includes: Supplementary data
Articles
Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL
Journal:
Biochemical Journal
Biochem J (2013) 456 (1): 55–66.
Published: 24 October 2013
...), as a VHL-interacting protein. GST pull-down and co-immunoprecipitation assays show that UXT interacts with VHL. In addition, UXT recruits VHL to the nucleus. VHL associates with the DBD (DNA-binding domain) and hinge domains of the AR and induces AR ubiquitination. Moreover, VHL interaction with the AR...
Includes: Supplementary data
Articles
Kenneth K. Y. Cheng, Karen S. L. Lam, Yu Wang, Donghai Wu, Mingliang Zhang, Baile Wang, Xiaomu Li, Ruby L. C. Hoo, Zhe Huang, Gary Sweeney, Aimin Xu
Journal:
Biochemical Journal
Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
... remain elusive. In the present study we show that insulin induces Lys 63 -linked ubiquitination of APPL1 in primary hepatocytes and in the livers of C57 mice. Lys 160 located within the BAR (Bin/amphiphysin/Rvs) domain of APPL1 is the major site for its ubiquitination. Replacement of Lys 160...
Includes: Supplementary data
Articles
Weihua Bian, Licui Sun, Longyan Yang, Ji-Feng Li, Jia Hu, Shuai Zheng, Ruihan Guo, Duiping Feng, Qian Ma, Xiaocui Shi, Ying Xiong, Xiaomei Yang, Ran Song, Jianguo Xu, Songlin Wang, Junqi He
Journal:
Biochemical Journal
Biochem J (2013) 453 (3): 345–356.
Published: 12 July 2013
... studies indicated that PSD95 enhanced Mas protein expression by increasing the stabilization of the receptor. Mas degradation was robustly inhibited by the proteasome inhibitor MG132 in time- and dose-dependent manners, and the expression of PSD95 impaired Mas ubiquitination, indicating that the PSD95–Mas...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (1): 139–145.
Published: 25 April 2013
...) Nck ubiquitination Data are presented as means±S.D. from three to five independent experiments. Statistical analyses were performed using Student's t test. P <0.05 was considered statistically significant. The excessive demand on the protein-folding capacity of the ER...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (3): 707–717.
Published: 09 January 2013
...Vivien Landré; Emmanuelle Pion; Vikram Narayan; Dimitris P. Xirodimas; Kathryn L. Ball Understanding the determinants for site-specific ubiquitination by E3 ligase components of the ubiquitin machinery is proving to be a challenge. In the present study we investigate the role of an E3 ligase...
Includes: Supplementary data
Articles
Ziguo Zhang, Jing Yang, Eric H. Kong, William C. H. Chao, Edward P. Morris, Paula C. A. da Fonseca, David Barford
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 365–371.
Published: 14 December 2012
... describe the generation of recombinant human APC/C (anaphase-promoting complex/cyclosome), an E3 ubiquitin ligase that regulates cell-cycle progression. Human APC/C is composed of 14 distinct proteins that assemble into a complex of at least 19 subunits with a combined molecular mass of ~1.2 MDa. We show...
Articles
Chenji Wang, Jian An, Pingzhao Zhang, Chen Xu, Kun Gao, Di Wu, Dejie Wang, Hongxiu Yu, Jun O. Liu, Long Yu
Journal:
Biochemical Journal
Biochem J (2012) 444 (2): 279–289.
Published: 11 May 2012
... how AMOT is regulated. In the present study, we report that AMOT undergoes proteasomal degradation. We identify three members of Nedd4 (neural-precursor-cell-expressed developmentally down-regulated)-like ubiquitin E3 ligases, Nedd4, Nedd4-2 and Itch, as the ubiquitin E3 ligases for the long isoform...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (3): 681–689.
Published: 16 April 2012
... (ubiquitin/proteasome system). Moreover, the ubiquitination level of mutant Htt was found to be enhanced when FE65 is knocked down. Immunofluroescence staining revealed that FE65 associates with mutant Htt aggregates. Additionally, we demonstrated that overexpression of FE65 increases mutant Htt-induced cell...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (3): 979–987.
Published: 16 January 2012
.... Polyubiquitination of TRAF2 and TRAF6 is critical to their activities and functions in TNFα- and IL (interleukin)-1β-induced NF-κB activation. However, the regulation of TRAF2 and TRAF6 by deubiquitination remains incompletely understood. In the present study, we identified USP (ubiquitin-specific protease) 4...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 399–406.
Published: 14 December 2011
.... Interestingly, not only reduced expression but also overexpression of Beclin 1 is correlated with cancer development and metastasis. Thus it seems necessary for the cell to balance the protein levels of Beclin 1. In the present study we describe a regulatory link between Beclin 1 and the ubiquitin ligase Nedd4...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 440 (1): 115–125.
Published: 27 October 2011
... and epoxomicin can stabilize STEP. The active form of STEP is more susceptible to degradation than the inactive form. Taken together the results of the present paper establish that ubiquitin-dependent proteolysis could be a novel mechanism for irreversibly terminating the activity of STEP. 1 To whom...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 437 (2): 255–267.
Published: 28 June 2011
... implicated in the internalization of the protein. In recent years, ubiquitination of Cx43 has also been proposed to regulate gap junction intercellular communication; however, the underlying mechanism and molecular players involved remain elusive. In the present study, we demonstrate that ubiquitinated Cx43...
Includes: Multimedia, Supplementary data
Articles
Jia Shen, Shengping Zhang, Yang Li, Wen Zhang, Jiandong Chen, Mary Zhang, Ting Wang, Ling Jiang, Xiuqun Zou, Jiemin Wong, Xiaotao Li, Yongping Cui, Chuangui Wang
Journal:
Biochemical Journal
Biochem J (2011) 434 (2): 275–285.
Published: 11 February 2011
... checkpoint’ function through both p53-dependent and p53-independent mechanisms. In the present study, we demonstrate a novel p53-independent interaction between p14 ARF and the adenovirus oncoprotein E1A. p14 ARF inhibits E1A transcriptional function and promotes ubiquitination-dependent degradation of E1A...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 31–42.
Published: 15 December 2010
...Dawn M. Wenzel; Kate E. Stoll; Rachel E. Klevit Ubiquitination is a post-translational modification pathway involved in myriad cellular regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three enzyme activities: a Ub-activating (E1) enzyme, a Ub-conjugating (E2) enzyme...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (1): 91–104.
Published: 15 March 2010
... and Sug1 contain caspase 8. Expression of Ac-Ipaf or co-expression of Sug1 with Ipaf results in the formation of cytoplasmic aggregates and caspase 8 activation. Sug1 co-expression enabled modification of Ipaf by ubiquitination. Tagging ubiquitin molecules to Ipaf led to aggregate formation, enhanced...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 1–10.
Published: 29 July 2009
.... Modifications of TLRs and their receptor proximal signalling proteins have also been uncovered. Phosphorylation of adaptor proteins and ubiquitination (both Lys 48 - and Lys 63 -linked) of TLRs, IRAKs (interleukin-1 receptor-associated kinase), Pellinos and TRAF6 (tumour-necrosis-factor-receptor-associated...
Articles
Mi-Young Jeong, Chang-Min Kang, Ji-Hyun Kim, Dong-Hyuk Heo, Miwha Chang, In-Joon Baek, Hyeon-Su Ro, Il-Dong Choi, Tae-Hyoung Kim, Cheol-Won Yun
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 181–191.
Published: 29 July 2009
... ubiquitination. These results suggest that Aft1 interacts with Arn3 and may regulate the ubiquitination of Arn3 in the cytosolic compartment. A pathway for FC uptake by Arn1 has been identified. Low concentrations of substrate induce Arn1 to localize to the plasma membrane, yet little uptake of the substrate...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 416 (1): 117–127.
Published: 28 October 2008
...-associated protein) complex to NF-κB target genes. Importantly, the molecular mechanisms which determine the functions of RelB are still largely unknown. In the present study, we aimed to analyse whether ubiquitination of RelB might be involved in the regulation of RelB. Indeed, RelB is constitutively...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 414 (2): 221–229.
Published: 12 August 2008
... and regulation of PTEN ubiquitination catalysed by NEDD4-1 (neural-precursor-cell-expressed, developmentally down-regulated 4-1), a ubiquitin ligase for PTEN we identified recently. Using the reconstituted assay and cellular analysis, we demonstrated that NEDD4-1-mediated PTEN ubiquitination depends on its...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): e9–e10.
Published: 27 March 2008
... transduction specificity ubiquitination The serine/threonine kinase LKB1 was first identified as a tumour-suppressor protein [ 1 ]. Mutation of LKB1 is linked to Peutz–Jehgers syndrome, a disease characterized by the development of intestinal hamartomas and an increased risk for the development...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 249–260.
Published: 27 March 2008
...-related kinases, NUAK1 (AMPK-related kinase 5) and MARK4 (microtubule-affinity-regulating kinase 4), are polyubiquitinated in vivo and interact with the deubiquitinating enzyme USP9X (ubiquitin specific protease-9). Knockdown of USP9X increased polyubiquitination of NUAK1 and MARK4, whereas overexpression...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...-R trafficking and degradation. EGF (17 nM) and BTC (8.5 nM) induced significant EGF-R degradation, with or without ectopic expression of the ubiquitin ligase Cbl. Human recombinant AR (17 nM) failed to affect receptor degradation in either case. Notably, levels of ligand-induced EGF-R ubiquitination...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 439–453.
Published: 27 February 2008
... proteins and development of Hsp90 inhibitors for therapeutic application. We also identify the deficiencies in our current knowledge and highlight key areas for future investigation. ATPase inhibitor cancer therapy client protein co-chaperone protein activation and degradation ubiquitination...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 275–287.
Published: 11 December 2007
... or Box 1 motifs. As a further consequence of activation by 3M-003, TLR8 is modified to yield both higher and lower molecular mass species. These species include a monoubiquitinated form as deduced from ubiquitin peptide sequencing by HPLC/MS/MS (tandem MS). By comparison, less is known about...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): 217–226.
Published: 11 December 2006
...Koh Nakayama; Stefan Gazdoiu; Robert Abraham; Zhen-Qiang Pan; Ze'ev Ronai PHD1–3 (prolyl hydroxylases 1–3) catalyse the hydroxylation of HIF (hypoxia-inducible factor)-α subunit that triggers the substrate ubiquitination and subsequent degradation. The RING (really interesting new gene) finger E3...
Articles
Larissa Belova, Sanjay Sharma, Deanna R. Brickley, Jeremy R. Nicolarsen, Cam Patterson, Suzanne D. Conzen
Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 235–244.
Published: 14 November 2006
...-associated E3 ligase CHIP [ C -terminus of H sc (heat-shock cognate protein) 70- i nteracting p rotein]; CHIP is required for both the ubiquitin modification and rapid proteasomal degradation of SGK-1. We also show that CHIP co-localizes with SGK-1 at or near the endoplasmic reticulum. CHIP-mediated...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 399 (3): 361–372.
Published: 13 October 2006
...James H. Hurley; Sangho Lee; Gali Prag The covalent modification of proteins by ubiquitination is a major regulatory mechanism of protein degradation and quality control, endocytosis, vesicular trafficking, cell-cycle control, stress response, DNA repair, growth-factor signalling, transcription...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 399 (3): 415–425.
Published: 13 October 2006
... by calcium deprivation, tankyrase returns from the lateral membrane to the cytoplasm and becomes more soluble in detergents. The PARsylating activity of tankyrase promotes its dissociation from the lateral membrane as well as its ubiquitination and proteasome-mediated degradation, resulting in an apparent...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 397 (1): 31–38.
Published: 14 June 2006
... of the E3 ubiquitin ligase, β-TrCP2 (β-transducin repeats-containing protein 2), ubiquitination of IFNAR1 and proteolysis. The non-catalytic role of Tyk2 in sustaining the steady-state IFNAR1 level at the plasma membrane is well documented; however, little is known about the function of Tyk2 in the steps...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 396 (3): 411–417.
Published: 29 May 2006
... domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain of unknown function and two RING (really interesting new gene) fingers separated by a ZZ zinc finger domain. Biochemical analyses revealed that MEX is self-ubiquitinated and targeted for degradation through the proteasome pathway. MEX can...
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