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Keywords: ubiquitins
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Biochem J (2023) 480 (22): 1817–1831.
Published: 17 November 2023
...Nicholas Purser; Ishita Tripathi-Giesgen; Jerry Li; Daniel C. Scott; Daniel Horn-Ghetko; Kheewoong Baek; Brenda A. Schulman; Arno F. Alpi; Gary Kleiger Protein ubiquitylation typically involves isopeptide bond formation between the C-terminus of ubiquitin to the side-chain amino group on Lys...
Includes: Supplementary data
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Biochem J (2021) 478 (18): 3467–3483.
Published: 30 September 2021
... is as a RING-type E3 ubiquitin (Ub) ligase, leading to the deposition of Ub signals onto a variety of substrate proteins. Distinct types of Ub signals deposited by BRCA1/BARD1 (i.e. degradative vs. non-degradative; mono-Ub vs. poly-Ub chains) on substrate proteins mediate aspects of its function in DNA double...
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Biochem J (2021) 478 (14): 2825–2842.
Published: 23 July 2021
...Thanh Thi Le; Johanna Ainsworth; Cristian Polo Rivera; Thomas Macartney; Karim P.M. Labib Cullin ubiquitin ligases drive replisome disassembly during DNA replication termination. In worm, frog and mouse cells, CUL2 LRR1 is required to ubiquitylate the MCM7 subunit of the CMG helicase. Here, we show...
Includes: Supplementary data
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Biochem J (2021) 478 (1): 261–279.
Published: 15 January 2021
...Marina Ikeda; Tadashi Watanabe; Akihiro Ito; Masahiro Fujimuro Herpes simplex virus 1 (HSV-1) is a human DNA virus that causes cold sores, keratitis, meningitis, and encephalitis. Ubiquitination is a post-translational protein modification essential for regulation of cellular events...
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Biochem J (2020) 477 (14): 2655–2677.
Published: 29 July 2020
... is sequential ubiquitination of proliferating cell nuclear antigen (PCNA), a DNA clamp required for replication and DNA repair. DDT consists of two parallel pathways: error-prone DDT is mediated by PCNA monoubiquitination, which recruits translesion synthesis DNA polymerases to bypass lesions with decreased...
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Biochem J (2020) 477 (12): 2193–2219.
Published: 22 June 2020
...Hitendra Negi; Pothula Purushotham Reddy; Vineeth Vengayil; Chhaya Patole; Sunil Laxman; Ranabir Das The Baculoviridae family of viruses encode a viral Ubiquitin (vUb) gene. Though the vUb is homologous to the host eukaryotic Ubiquitin (Ub), its preservation in the viral genome indicates unique...
Includes: Supplementary data
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Biochem J (2020) 477 (2): 477–489.
Published: 31 January 2020
...) with fresh protease inhibitors (Sigma–Aldrich), and the supernatant was centrifuged at 4°C for 20 min at 13 000 rpm. The ubiquitination of protein needs to be treated with or without 10 μM MG132 for an additional 6 h to block proteasomal degradation of protein after transfection for 24 h. Then the co...
Includes: Supplementary data
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Biochem J (2018) 475 (9): 1569–1582.
Published: 09 May 2018
...Adaitya Prasad Behera; Pritam Naskar; Shubhangi Agarwal; Prerana Agarwal Banka; Asim Poddar; Ajit B. Datta RING ( R eally I nteresting N ew G ene) domains in ubiquitin RING E3 ligases exclusively engage ubiquitin (Ub)-loaded E2s to facilitate ubiquitination of their substrates. Despite...
Includes: Supplementary data
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