... structural approaches to visualize and build a more complete understanding of protein dynamics at the break site. © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 DNA damage signaling mediators phosphorylation sensors ubiquitylation...

... inhibitor of septin oligomerization, decreased surface and total levels of ErbB2. These treatments had no effect on epidermal growth factor receptor (EGFR), emphasizing the specificity and functionality of the septin–ErbB2 interaction. The level of ubiquitylated ErbB2 at the plasma membrane was elevated...

... chemical biology chemoenzymatic isopeptide ligation post-translational modification semisynthesis ubiquitin ubiquitination ubiquitylation Modification of substrate proteins with ubiquitin (Ub) and polyubiquitin (polyUb) chains of diverse topology is now firmly established as a crucial...

... physically associates with the LD1 motif of the focal adhesion protein paxillin. We reveal that MEKK2 induces paxillin ubiquitylation, and that this function requires both the paxillin LD1 motif and MEKK2 kinase activity. Finally, we demonstrate that MEKK2 promotes paxillin redistribution from focal...

.... This ubiquitylation signals the clearance of the damaged mitochondria to preserve overall cell health. Recent structural and biochemical experiments have shown that native Parkin exists in an autoinhibited state that must be activated in order to unmask its full ubiquitylation potential. In a recent article...

... known mammalian kinase that is also a ubiquitin ligase. MEKK1 contains a RING domain within its N-terminal regulatory region, and MEKK1 has been shown to ubiquitylate the AP-1 (activator protein 1) transcription factor protein c-Jun, but the mechanism by which MEKK1 interacts with c-Jun to induce...

... (PI3K) stability Ras association (RalGDS/AF-6) domain family member 1C (RASSF1C) ubiquitylation RASSF1 [Ras association (RalGDS/AF-6) domain family member 1] is located in chromosome 3p21.3, which frequently undergoes loss of heterozygosity in human tumours [ 1 , 2 ]. RASSF1A and RASSF1C, two...

... 2010 RING domain tripartite motif protein (TRIM protein) ubiquitin-conjugating E2 enzyme ubiquitin E3 ligase ubiquitylation The proteins that belong to the TRIM (tripartite motif) family, also known as the RBCC (RING finger, B-box and coiled-coil) family, are defined by the presence...