... Biochemical Society 2013 autophagy endoplasmic reticulum stress hypoxia integrated stress response UNC51-like kinase 1 (ULK1) unfolded protein response (UPR) The microenvironment of a solid tumour is both hostile and heterogeneous, characterized by extremes in pH, metabolite concentrations...

... misfolding retinal disease unfolded protein response (UPR) © The Authors Journal compilation © 2012 Biochemical Society 2012 6 6 2011 3 10 2011 13 10 2011 13 10 2011 1 To whom correspondence should be addressed (email [email protected] ). For expression...

... To whom correspondence should be addressed (email [email protected] ). 23 8 2010 22 9 2010 18 10 2010 18 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 acetylation cell death p300 sirtuin 1 (SIRT1) unfolded protein response (UPR) X-box-binding...

...). The detection system employed was the ECL Plus™ Western Blotting Reagents (GE Healthcare). gene expression internal ribosome entry site (IRES) sterol-regulatory-element-binding protein-1 (SREBP-1) translational regulation unfolded protein response (UPR) 5′-untranslated region (5′-UTR) Lipid...

... compilation © 2010 Biochemical Society 2010 post-translational modification protein inhibitor of activated signal transducer and activator of transcription (PIAS) small ubiquitin-related modifier (SUMO) transcriptional regulation unfolded protein response (UPR) X-box-binding protein 1 (XBP1...

... 8 2009 3 9 2009 3 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 autophagy ceramide ceramide synthase endoplasmic reticulum (ER) homoeostasis growth arrest unfolded protein response (UPR) Ceramide, a building block of biological membranes...

... nutrient sensing unfolded protein response (UPR) ER (endoplasmic reticulum) stress represents an imbalance between ER protein load and ER processing capacity [ 1 ]. Cellular stresses that lead to perturbation in calcium homoeostasis, abnormal protein glycosylation, glucose deprivation...

.... 1 To whom correspondence should be addressed (email [email protected] ). 13 12 2006 26 2 2007 5 3 2007 5 3 2007 © 2007 Biochemical Society 2007 endoplasmic reticulum-associated degradation (ERAD) p27 p53 proteasomal degradation ubiquitin unfolded protein...

... kDa glucose-regulated protein (GRP78) mitochondrial targeting unfolded protein response (UPR) The crude mitochondria were resuspended in mitochondria isolation buffer, laid over a 1–1.5 M sucrose step gradient in 10 mM Tris/HCl (pH 7.5) and 1 mM EDTA and then centrifuged at 60000  g...

... Society, London 2005 endoplasmic reticulum chaperone immunoglobulin heavy-chain binding protein (BiP)/78 kDa glucose-regulated protein (GRP78) Ire1 partial proteolysis stress sensor unfolded protein response (UPR) For native PAGE (5–20% polyacrylamide), 3 μg of proteins were diluted...