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Keywords: ventricular tachycardia
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Articles

Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca 2+ release and catecholaminergic polymorphic ventricular tachycardia

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Zhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D. Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G. Back, Michael Fill, S. R. Wayne Chen
Journal: Biochemical Journal
Biochem J (2016) 473 (22): 4159–4172.
https://doi.org/10.1042/BCJ20160620
Published: 10 November 2016
... or prostaglandin E2) alone did not inhibit SOICR. Hence, nebivolol's SOICR inhibition was independent of NOS stimulation. Like carvedilol, nebivolol reduced the opening of single RyR2 channels and suppressed spontaneous Ca 2+ waves in intact hearts and catecholaminergic polymorphic ventricular tachycardia (CPVT...
View articletitled, Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca 2+ release and catecholaminergic polymorphic ventricular tachycardia
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Articles

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca 2+ release and destabilizes the N-terminal domains

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Yingjie Liu, Lynn Kimlicka, Florian Hiess, Xixi Tian, Ruiwu Wang, Lin Zhang, Peter P. Jones, Filip Van Petegem, S. R. Wayne Chen
Journal: Biochemical Journal
Biochem J (2013) 454 (1): 123–131.
https://doi.org/10.1042/BJ20130594
Published: 26 July 2013
...Yingjie Liu; Lynn Kimlicka; Florian Hiess; Xixi Tian; Ruiwu Wang; Lin Zhang; Peter P. Jones; Filip Van Petegem; S. R. Wayne Chen CPVT (catecholaminergic polymorphic ventricular tachycardia) is an inherited life-threatening arrhythmogenic disorder. CPVT is caused by DADs (delayed after...
View articletitled, The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca 2+ release and destabilizes the N-terminal domains
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