... little and too much of adipose tissue, especially white adipose tissue, can cause severe metabolic complications, where lipodystrophy, referring to the lack of adipose tissue, causes similar metabolic impairments as obesity [ 6 ]. While hereditary and acquired lipodystrophy are relatively rare, the rates...

... was enabled by the participation of Imperial College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. adipocytes brown adipose tissue thermogenesis white adipose tissue The dramatic rise...

...Greg L. McKie; David C. Wright Our understanding of white adipose tissue (WAT) biochemistry has evolved over the last few decades and it is now clear that WAT is not simply a site of energy storage, but rather a pliable endocrine organ demonstrating dynamic responsiveness to the effects of aerobic...

... of adipose tissue under normal and pathological conditions. scRNAseq has recently been used to characterize adipose stem cell (ASC) populations and has provided new insights into subpopulations of macrophages that arise during anabolic and catabolic remodeling in white adipose tissue. The current review...

... obesity proteomics rat models type 2 diabetes white adipose tissue The unquestioned role of obesity-induced insulin resistance in the pathogenesis of type-2 diabetes mellitus (T2DM), a metabolic disease estimated to affect more than 400 million people worldwide [ 1 ], is an important...

... in permeabilized perirenal, inguinal, and interscapular adipose tissue. White adipose tissue (WAT) mitochondria (inguinal and perirenal) respire at substantially lower rates compared with brown adipose tissue (BAT). Insulin treatment resulted in a significant reduction in mitochondrial respiration in inguinal WAT...

... of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid droplet and play well-known roles in energy storage. By contrast, brown adipose tissue is specialized for thermogenic energy expenditure. Owing to its significant capacity to dissipate...

... Pgc1a PPARγ co-activator-α gene Pref-1 pre-adipocyte factor-1 UCP1 uncoupling protein 1 WAT white adipose tissue References 1 Cinti S. The adipose organ. Prostaglandins, Leukotrienes Essent Fatty Acids 2005 73 9 15 2 Kajimura S. Seale P...