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Ryota Shizu, Taiki Abe, Satoshi Benoki, Miki Takahashi, Susumu Kodama, Masaaki Miayata, Atsushi Matsuzawa, Kouichi Yoshinari
Biochem J (2016) 473 (3): 257–266.
Published: 25 January 2016
... (PXR), is a key transcription factor for the xenobiotic-induced expression of genes associated with various liver functions. Recently, we reported that PXR activation stimulates xenobiotic-induced hepatocyte proliferation. In the present study, we investigated whether PXR activation also stimulates...
Includes: Supplementary data
Biochem J (2006) 395 (3): 599–609.
Published: 11 April 2006
... transcriptional activation in response to exposure to xenobiotics. To define the mechanism of Mrp2 gene induction, the 5′-flanking region of the mouse Mrp2 gene (2.0 kb) was isolated, and two ARE-like sequences were found: ARE-2 (−1391 to −1381) and ARE-1 (−95 to −85). Deletion analyses demonstrated that the...
Biochem J (2005) 388 (1): 299–307.
Published: 10 May 2005
... Biochemical Society, London 2005 detoxification glutathione conjugation hepatopancreas Pagrus major red sea bream xenobiotics GSH is a tripeptide that acts during phase II metabolism to conju-gate electrophiles and prevents damage to cell membranes and other macromolecules. Since GSH is...
Biochem J (2002) 366 (3): 817–824.
Published: 15 September 2002
... Biochemical Society, London ©2002 2002 detoxification glutathione conjugation mouse small intestine xenobiotics Abbreviations used: Δ 5 -AD, Δ 5 -androstene-3,17-dione; (±)- anti- BPDE, racemic anti- benzo[ a ]pyrene-7,8-diol-9,10-epoxide; BSP, bromosulphophthalein; CDNB, 1-chloro-2,4...
Bartolo FAVALORO, Antonio TAMBURRO, Massimo A. TROFINO, Luciano BOLOGNA, Domenico ROTILIO, Hermann J. HEIPIEPER
Biochem J (2000) 346 (2): 553–559.
Published: 22 February 2000
... presence of aliphatic alcohols or heavy metals. These results suggest a co-regulation of the OaGST gene by the catabolic pathways of phenols and chlorophenols in this bacterium. Therefore, OaGST could function as a detoxifying agent within the catabolism of these xenobiotics. 1 To whom...
Biochem J (1999) 341 (1): 105–111.
Published: 24 June 1999
... xenobiotics, cMoat has also been proposed to transport GSH into bile, the major driving force of bile-acid-independent bile flow. We have shown previously that the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), a peroxisome-proliferator agent, significantly increases bile-acid-independent bile flow in...