The regulation of the synthesis of PtdIns(4,5)P2 is emerging as being as complex as we might expect from the multi-functional nature of this lipid. In the present chapter we focus on one aspect of inositide metabolism, which is the functions of the Type II PIPkins (Type II PtdInsP kinases). These are primarily PtdIns5P 4-kinases, although in vitro they will also phosphorylate PtdIns3P to PtdIns(3,4)P2. Thus they have three, not necessarily exclusive, functions: to make PtdIns(4,5)P2 by a quantitatively minor route, to remove PtdIns5P and to make PtdIns(3,4)P2 by a route that does not involve a Class I PtdIns 3-kinase. None of these three possible functions has yet been unambiguously proven or ruled out. Of the three isoforms, α and β are widely expressed, the IIα being predominantly cytosolic and the IIβ primarily nuclear. PIPkin IIγ has a much more restricted tissue expression pattern, and appears to be localized primarily to intracellular vesicles. Here we introduce in turn each of the three Type II PIPkins, and discuss what we know about their localization, their regulation and their function.
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January 2007
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Conference Article|
January 21 2007
Type II PtdInsP kinases: location, regulation and function
Jonathan H. Clarke;
Jonathan H. Clarke
*Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, U.K.
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Jonathan P. Richardson;
Jonathan P. Richardson
*Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, U.K.
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Katherine A. Hinchliffe;
Katherine A. Hinchliffe
†The Faculty of Life Sciences, The University of Manchester, 2nd Floor, Core Technology Facility, 46, Grafton Street, Manchester M13 9NT, U.K.
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Robin F. Irvine
Robin F. Irvine
1
*Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2007) 74: 149–159.
Citation
Michael J.O. Wakelam, Jonathan H. Clarke, Jonathan P. Richardson, Katherine A. Hinchliffe, Robin F. Irvine; Type II PtdInsP kinases: location, regulation and function. Biochem Soc Symp 12 January 2007; 74 149–159. doi: https://doi.org/10.1042/BSS2007c14
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