Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosphates. Discoveries of inositide receptors and novel mechanisms of inositide action have provided important insights into how such messengers couple to nuclear machinery. In this chapter, we discuss the IPK family members and the nuclear processes that their inositide products regulate.
Conference Article| January 21 2007
Inositol polyphosphate kinases: regulators of nuclear function
Andrew M. Seeds;
Andrew M. Seeds
*Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham NC 27710, U.S.A.
2Department of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham NC 27710, U.S.A.
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Biochem Soc Symp (2007) 74: 183-197.
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Michael J.O. Wakelam, Andrew M. Seeds, John D. York; Inositol polyphosphate kinases: regulators of nuclear function. Biochem Soc Symp 12 January 2007; 74 183–197. doi: https://doi.org/10.1042/BSS2007c16
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