A number of iron-chelating agents are currently being considered as orally active alternatives to desferrioxamine (DFO), the therapeutic agent for the treatment of body iron overload that is available at present. These include bidentate hydroxypyridinones (HPO), tridentate desferrithiocin (DFT) analogues and hexadentate aminocarboxylate (HBED) chelators. All chelating agents have the potential to induce toxic effects when iron homoeostasis is affected within the body. This can arise when the absorption, distribution and utilization of iron is affected. Alternatively, chelating agents can induce toxicity by directly interfering with iron-dependent metalloenzymes located within the body. These effects are, however, mainly localized to non-haem enzymes such as ribonucleotide reductase and lipoxygenase. The resultant iron complexes also have the ability to induce toxicity. Depending on the coordination geometry and donor atoms associated with the metal centre, redox cycling of the iron centre with the corresponding generation of free radicals can result.
Skip Nav Destination
Article navigation
November 1995
Issue Editors
-
Cover Image
Cover Image
Conference Article|
November 01 1995
Therapeutic iron chelators and their potential side-effects
S. Singh;
S. Singh
1Department of Pharmacy, King's College, University of London, Manresa Road, London SW3 6LX, U.K.
Search for other works by this author on:
Hh Khodr;
Hh Khodr
1Department of Pharmacy, King's College, University of London, Manresa Road, London SW3 6LX, U.K.
Search for other works by this author on:
M. I. Taylor;
M. I. Taylor
1Department of Pharmacy, King's College, University of London, Manresa Road, London SW3 6LX, U.K.
Search for other works by this author on:
R. C. Hider
R. C. Hider
1Department of Pharmacy, King's College, University of London, Manresa Road, London SW3 6LX, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 1995 The Biochemical Society
1995
Biochem Soc Symp (1995) 61: 127–137.
Citation
C. Rice-Evans, B. Halliwell, G.G. Lunt, S. Singh, Hh Khodr, M. I. Taylor, R. C. Hider; Therapeutic iron chelators and their potential side-effects. Biochem Soc Symp 1 November 1995; 61 127–137. doi: https://doi.org/10.1042/bss0610127
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Related Articles
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
Biochem J (April,2003)
A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry
Biochem J (October,2014)
Intracellular low molecular weight iron
Biochem Soc Trans (June,1989)
Putrescine uptake by the cellular slime mould dictyostelium discoideum
Biochem J (April,1979)