Inhalation of ozone (O3) and/or nitrogen dioxide (.NO2) is associated with the development of inflammation in the respiratory tract and various alterations in pulmonary functions. Respiratory tract lining fluids (RTLFs) represent the first biological fluids coming into contact with these inhaled toxicants. Using plasma as a surrogate for RTLFs, we have previously shown that O3 [Cross, Motchnik, Bruener, Jones, Kaur, Ames and Halliwell (1992) FEBS Lett. 298, 269-272] and .NO2 [Halliwell, Hu, Louie, Duvall, Tarkington, Motchnik and Cross (1992) FEBS Lett. 313, 62-66] are both capable of depleting antioxidants and damaging proteins and lipids. O3 particularly damages proteins, whereas .NO2 induces the peroxidation of lipids and nitrates aromatic amino acids. It has been reported that O3 and .NO2 cause synergistic toxicity in rodents [Gielzleichter, Witschi and Last (1992) Tox. Appl. Pharmacol. 116, 1-9]. In the present chapter, we review evidence showing that combined exposure of these two oxidant gases to human plasma fails to exert synergistic oxidative damage to plasma constituents, and in fact, O3 and .NO2 antagonize each other's actions. We conclude that the potentiating effect of these two gases on morbidity and mortality in rodents represents a complex interactive biological effect rather than a simple synergistic oxidative effect in extracellular fluids.
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November 1995
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Conference Article|
November 01 1995
Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid
Charles A. O'Neill;
Charles A. O'Neill
*Division of Pulmonary-Critical Care Medicine, UC Davis School of Medicine, University of California, Davis, CA, U.S.A.
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Albert van der Vliet;
Albert van der Vliet
*Division of Pulmonary-Critical Care Medicine, UC Davis School of Medicine, University of California, Davis, CA, U.S.A.
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Jason P. Eiserich;
Jason P. Eiserich
*Division of Pulmonary-Critical Care Medicine, UC Davis School of Medicine, University of California, Davis, CA, U.S.A.
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Jerold A. Last;
Jerold A. Last
*Division of Pulmonary-Critical Care Medicine, UC Davis School of Medicine, University of California, Davis, CA, U.S.A.
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Barry Halliwell;
Barry Halliwell
†Neurodegenerative Disease Research Centre, King's College, University of London, London, U.K.
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Carroll E. Cross
Carroll E. Cross
1
*Division of Pulmonary-Critical Care Medicine, UC Davis School of Medicine, University of California, Davis, CA, U.S.A.
1To whom correspondence should be addressed.
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 1995 The Biochemical Society
1995
Biochem Soc Symp (1995) 61: 139–152.
Citation
C. Rice-Evans, B. Halliwell, G.G. Lunt, Charles A. O'Neill, Albert van der Vliet, Jason P. Eiserich, Jerold A. Last, Barry Halliwell, Carroll E. Cross; Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid. Biochem Soc Symp 1 November 1995; 61 139–152. doi: https://doi.org/10.1042/bss0610139
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