New atherosclerosis causative factors and preventive modalities have been identified. Atherogenic factors include lipid oxidation products, such as cholesterol oxidation products, malonaldehyde and other aldehydes; trans-fatty acids; some saturated fatty acids (lauric, myristic and possibly palmitic acids); and myristic acid plus cholesterol. Lipid oxidation products are well suited to induce arterial damage, based on their known cytotoxic effects; evidence also indicates the possibility of plaque promotion and stimulation of thrombogenesis. Anti-atherogenic factors include antioxidants, fish oils and other polyunsaturates (if protected from oxidation), fibre and trace minerals such as copper, manganese, selenium and zinc. Iron is unique, being considered as both a potential promoter of atherosclerosis (component of ferritin, conceivably inducing lipid oxidation) and a possible anti-atherogenic component (of antioxidant enzyme catalase). It is apparent that an entire new series of research challenges has been uncovered.
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November 1995
Issue Editors
Conference Article|
November 01 1995
Atherogenic and anti-atherogenic factors in the human diet
P.B. Addis
;
P.B. Addis
*Department of Food Science and Nutrition, I334 Eckles Avenue, University of Minnesota, St. Paul, MN 55 108, U.S.A.
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T.P. Carr
;
T.P. Carr
*Department of Food Science and Nutrition, I334 Eckles Avenue, University of Minnesota, St. Paul, MN 55 108, U.S.A.
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C.A. Hassel
;
C.A. Hassel
*Department of Food Science and Nutrition, I334 Eckles Avenue, University of Minnesota, St. Paul, MN 55 108, U.S.A.
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Z.Z. Huang
;
Z.Z. Huang
†Department of Family Practice and Community Health, University of Minnesota, 20 I Washington Avenue, S. E. Minneapolis, MN 55455, U.S.A.
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G.J. Warner
G.J. Warner
†Department of Family Practice and Community Health, University of Minnesota, 20 I Washington Avenue, S. E. Minneapolis, MN 55455, U.S.A.
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Biochem Soc Symp (1995) 61: 259–271.
Citation
C. Rice-Evans, B. Halliwell, G.G. Lunt, P.B. Addis, T.P. Carr, C.A. Hassel, Z.Z. Huang, G.J. Warner; Atherogenic and anti-atherogenic factors in the human diet. Biochem Soc Symp 1 November 1995; 61 259–271. doi: https://doi.org/10.1042/bss0610259
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