Siglecs are sialic-acid-binding proteins of the Ig superfamily that are involved in cell–cell interactions and signalling. In recent years, several novel siglecs that are highly related to CD33/Siglec-2 have been identified through genomics and functional screens. In addition to their distinct sialic-acid-binding properties, most of these novel siglecs bear tyrosine-based signalling motifs that are typically found in inhibitory receptors of the immune system. The restricted expression patterns of CD33-related siglecs in the haemopoietic and immune systems suggests that they are involved in regulating leucocyte activation during inflammatory and immune responses.
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Conference Article| October 01 2002
New I-type lectins of the CD 33-related siglec subgroup identified through genomics
Paul R. Crocker ;
Paul R. Crocker 1
1Wellcome Trust Biocentre, Division of Cell Biology and Immunology, School of Life Sciences, Dundee University, Dow Street, Dundee DD1 5EH, U.K.
1To whom correspondence should be addressed (e-mail firstname.lastname@example.org).
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Biochem Soc Symp (2002) 69: 83–94.
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Kurt Drickamer, Anne Dell, Paul R. Crocker, Jiquan Zhang; New I-type lectins of the CD 33-related siglec subgroup identified through genomics. Biochem Soc Symp 1 October 2002; 69 83–94. doi: https://doi.org/10.1042/bss0690083
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