The NO receptor, NO-sensitive guanylyl cyclase, plays a key role in the NO/cGMP signal-transduction cascade. Two isoforms of the enzyme are currently known, the widely distributed vascular α1ϐ1 isoform and the neuronal α2ϐ1 isoform predominantly expressed in brain. Interaction with the PSD-95 (postsynaptic density protein-95) family of scaffolding proteins targets the neuronal α2ϐ1 isoform to synaptic membranes. The NO sensor of the guanylyl cyclase is formed by the prosthetic haem group, where NO binding takes place and induces the up to 200-fold activation of the enzyme. The haem group allows tight regulation of enzymic activity by NO and represents the most striking feature of the enzyme, as it differs in many aspects from the well-characterized haem groups of other haemoproteins. The new NO sensitizers such as YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] affect activation by NO and CO by mechanisms that are currently subject to intense research.
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March 2004
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Conference Article|
March 01 2004
Guanylyl cyclase: NO hits its target
Michael Russwurm;
Michael Russwurm
1Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr-Universität Bochum, 44780 Bochum, Germany.
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Doris Koesling
Doris Koesling
1
1Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr-Universität Bochum, 44780 Bochum, Germany.
1To whom correspondence should be addressed (e-mail [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2004 The Biochemical Society
2004
Biochem Soc Symp (2004) 71: 51–63.
Citation
Chris Cooper, Mike Wilson, Victor Darley-Usmar, Michael Russwurm, Doris Koesling; Guanylyl cyclase: NO hits its target. Biochem Soc Symp 1 March 2004; 71 51–63. doi: https://doi.org/10.1042/bss0710051
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