A critical element in the ability of endothelial NO to function in the vasculature is preventing its reaction with erythrocytic Hb (haemoglobin). Emerging concepts suggest that the biophysical and rheological properties of the red blood cell are important in meeting this criterion. It has been recognized for some time that cell-free Hb may react with endothelial NO and that this may underlie the problems with Hb-based blood substitutes. More recent data extend these concepts to haemolytic diseases, including sickle cell disease, and have also identified novel therapeutic strategies to prevent interactions of cell-free Hb with NO. In this overview we have hypothesized that production of high concentrations of NO can overcome the diffusional barriers presented by the red cell and result in formation of S-nitrosohaemoglobin. By doing so, it is hypothesized that Hb may mediate the vasodilatory potential of NO and contribute to the hypotensive responses observed in acute inflammatory diseases, including sepsis.
Skip Nav Destination
Close
Article navigation
March 2004
Issue Editors
- Cover Image
- PDF Icon PDF LinkFront Matter
Conference Article|
March 01 2004
Regulation of vascular function by haemoglobin
Jack H. Crawford
;
Jack H. Crawford
1Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Street South, Birmingham, AL 35294, U.S.A.
Search for other works by this author on:
Balu K. Chacko
;
Balu K. Chacko
1Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Street South, Birmingham, AL 35294, U.S.A.
Search for other works by this author on:
Rakesh P. Patel
Rakesh P. Patel
1
1Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Street South, Birmingham, AL 35294, U.S.A.
1To whom correspondence should be addressed (e-mail patel@path.uab.edu).
Search for other works by this author on:
Biochem Soc Symp (2004) 71: 135–142.
Citation
Chris Cooper, Mike Wilson, Victor Darley-Usmar, Jack H. Crawford, Balu K. Chacko, Rakesh P. Patel; Regulation of vascular function by haemoglobin. Biochem Soc Symp 1 March 2004; 71 135–142. doi: https://doi.org/10.1042/bss0710135
Download citation file:
Close
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
3
Views
0
Citations
Cited By
Related Articles
Kinetics of NO and O 2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin
Biochem J (August,2004)
Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin
Biochem J (January,2007)
The properties and reactions of haemoglobin F I and their bearing on the dissociation equilibrium of haemoglobin
Biochem J (December,1966)
Reactions involving superoxide and normal and unstable haemoglobins
Biochem J (June,1976)