The organization of intracellular compartments and the transfer of components between them are central to the correct functioning of mammalian cells. Proteins and lipids are transferred between compartments by the formation, movement and subsequent specific fusion of transport intermediates. These vesicles and membrane clusters must be coupled to the cytoskeleton and to motor proteins that drive motility. Anterograde ER (endoplasmic reticulum)-to-Golgi transport, and the converse step of retrograde traffic from the Golgi to the ER, are now known to involve coupling of membranes to the microtubule cytoskeleton. Here we shall discuss our current understanding of the mechanisms that link membrane traffic in the early secretory pathway to the microtubule cytoskeleton in mammalian cells. Recent data have also provided molecular detail of functional co-ordination of motor proteins to specify directionality, as well as mechanisms for regulating motor activity by protein phosphorylation.
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January 2005
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Review Article|
January 01 2005
The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Krysten J. Palmer;
Krysten J. Palmer
1Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, U.K.
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Peter Watson;
Peter Watson
1Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, U.K.
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David J. Stephens
David J. Stephens
1
1Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2005 The Biochemical Society
2005
Biochem Soc Symp (2005) 72: 1–13.
Citation
Jeff McIlhinney, Nigel Hooper, Krysten J. Palmer, Peter Watson, David J. Stephens; The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.. Biochem Soc Symp 1 January 2005; 72 1–13. doi: https://doi.org/10.1042/bss0720001
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