Cargo proteins moving along the secretory pathway are sorted at the TGN (trans-Golgi network) into distinct carriers for delivery to the plasma membrane or endosomes. Recent studies in yeast and mammals have shown that formation of these carriers is regulated by PtdIns(4)P. This phosphoinositide is abundant at the TGN and acts to recruit components required for carrier formation to the membrane. Other phosphoinositides are also present on the TGN, but the extent to which they regulate trafficking is less clear. Further characterization of phosphoinositide kinases and phosphatases together with identification of new TGN-associated phosphoinositide-binding proteins will reveal the extent to which different phosphoinositides regulate TGN trafficking, and help define the molecular mechanisms involved.
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January 2005
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Review Article|
January 01 2005
Phosphoinositides and membrane traffic at the trans-Golgi network.
Rawshan R. Choudhury;
Rawshan R. Choudhury
1School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, U.K.
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Noora Hyvola;
Noora Hyvola
1School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, U.K.
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Martin Lowe
Martin Lowe
1
1School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2005 The Biochemical Society
2005
Biochem Soc Symp (2005) 72: 31–38.
Citation
Jeff McIlhinney, Nigel Hooper, Rawshan R. Choudhury, Noora Hyvola, Martin Lowe; Phosphoinositides and membrane traffic at the trans-Golgi network.. Biochem Soc Symp 1 January 2005; 72 31–38. doi: https://doi.org/10.1042/bss0720031
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