MOZ (monocytic leukaemia zinc finger protein; also known as ZNF220 or MYST3) is a member of the MYST family of protein acetyltransferases. Chromosomal translocations involving the MOZ gene are associated with AML (acute myeloid leukaemia), suggesting that it has a role in haematopoiesis. Recurrent reciprocal translocations fuse the MOZ gene [or the gene encoding MORF (MOZ-related factor); also known as MYST4] to genes encoding the nuclear receptor co-activators CBP [CREB (cAMP response element-binding protein)-binding protein], p300 or the p160 protein TIF2 (transcription intermediary factor 2). The resulting fusion proteins can transform haematopoietic progenitors in vitro, and induce myeloproliferative disease in mice. Recent insights into the molecular mechanisms underlying these effects indicate that MOZ fusion proteins interfere with the activities of transcription factors such as nuclear receptors, p53 and Runx proteins. Our studies suggest that subverting the function of cellular CBP and p300 proteins may play a key role in this process. Here we review the recent progress in understanding the role of MOZ fusion proteins in the aetiology of AML.
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January 2006
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Conference Article|
January 01 2006
MOZ fusion proteins in acute myeloid leukaemia
Philip J.F. Troke;
Philip J.F. Troke
1School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
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Karin B. Kindle;
Karin B. Kindle
1School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
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Hilary M. Collins;
Hilary M. Collins
1School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
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David M. Heery
David M. Heery
1
1School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 23–39.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Philip J.F. Troke, Karin B. Kindle, Hilary M. Collins, David M. Heery; MOZ fusion proteins in acute myeloid leukaemia. Biochem Soc Symp 1 January 2006; 73 23–39. doi: https://doi.org/10.1042/bss0730023
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