The recognition of changes in environmental conditions, and the ability to adapt to these changes, is essential for the viability of cells. There are numerous well characterized systems by which the presence or absence of an individual metabolite may be recognized by a cell. However, the recognition of a metabolite is just one step in a process that often results in changes in the expression of whole sets of genes required to respond to that metabolite. In higher eukaryotes, the signalling pathway between metabolite recognition and transcriptional control can be complex. Recent evidence from the relatively simple eukaryote yeast suggests that complex signalling pathways may be circumvented through the direct interaction between individual metabolites and regulators of RNA polymerase II-mediated transcription. Biochemical and structural analyses are beginning to unravel these elegant genetic control elements.
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January 2006
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Conference Article|
January 01 2006
Nutrient-regulated gene expression in eukaryotes
Richard J. Reece;
Richard J. Reece
1
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Laila Beynon;
Laila Beynon
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Stacey Holden;
Stacey Holden
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Amanda D. Hughes;
Amanda D. Hughes
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Karine Rébora;
Karine Rébora
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Christopher A. Sellick
Christopher A. Sellick
1Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 85–96.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Richard J. Reece, Laila Beynon, Stacey Holden, Amanda D. Hughes, Karine Rébora, Christopher A. Sellick; Nutrient-regulated gene expression in eukaryotes. Biochem Soc Symp 1 January 2006; 73 85–96. doi: https://doi.org/10.1042/bss0730085
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