At the replication fork, nucleosomes, transcription factors and RNA polymerases are stripped off the DNA, the DNA double strands are unzipped and DNA methylation marks may be erased. Therefore DNA replication is both a ‘curse’ and ‘bliss’ for the epigenome, as it disrupts its stability by causing chromatin perturbations, yet it offers an opportunity to initiate changes in chromatin architecture and gene expression patterns, especially during development. Thus the DNA replication site is a critical point for regulation. It has become apparent that there is a close functional relationship between those factors that regulate transcriptional competence and the DNA replication programme. In this review we discuss novel insights into how chromatin-remodelling factors at replication sites are involved in both the maintenance and regulation of transcriptional states.
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January 2006
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Conference Article|
January 01 2006
Chromatin-remodelling factors and the maintenance of transcriptional states through DNA replication
Sofia Aligianni;
Sofia Aligianni
1Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, U.K.
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Patrick Varga-Weisz
Patrick Varga-Weisz
1
1Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, U.K.
1To whom correspondence should be sent, at present address: Babraham Institute, Babraham, Cambridge CB2 4AT, U.K. (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 97–108.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Sofia Aligianni, Patrick Varga-Weisz; Chromatin-remodelling factors and the maintenance of transcriptional states through DNA replication. Biochem Soc Symp 1 January 2006; 73 97–108. doi: https://doi.org/10.1042/bss0730097
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