The proto-oncogene product c-Myc can induce cell growth and proliferation. It regulates a large number of RNA polymerase II-transcribed genes, many of which encode ribosomal proteins, translation factors and other components of the biosynthetic apparatus. We have found that c-Myc can also activate transcription by RNA polymerases I and III, thereby stimulating production of rRNA and tRNA. As such, c-Myc may possess the unprecedented capacity to induce expression of all ribosomal components. This may explain its potent ability to drive cell growth, which depends on the accumulation of ribosomes. The activation of RNA polymerase II transcription by c-Myc is often inefficient, but its induction of rRNA and tRNA genes can be very strong in comparison. We will describe what is known about the mechanisms used by c-Myc to activate transcription by RNA polymerases I and II.
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January 2006
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January 01 2006
Activation by c-Myc of transcription by RNA polymerases I, II and III
Natividad Gomez-Roman;
Natividad Gomez-Roman
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Zoë A. Felton-Edkins;
Zoë A. Felton-Edkins
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Niall S. Kenneth;
Niall S. Kenneth
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Sarah J. Goodfellow;
Sarah J. Goodfellow
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Dimitris Athineos;
Dimitris Athineos
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Jingxin Zhang;
Jingxin Zhang
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Ben A. Ramsbottom;
Ben A. Ramsbottom
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Fiona Innes;
Fiona Innes
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Theodoros Kantidakis;
Theodoros Kantidakis
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Elaine R. Kerr;
Elaine R. Kerr
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Jacqueline Brodie;
Jacqueline Brodie
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
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Carla Grandori;
Carla Grandori
†Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, U.S.A.
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Robert J. White
Robert J. White
1
∗Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, U.K.
1To whom correspondence should be addressed (email [email protected])
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 141–154.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Natividad Gomez-Roman, Zoë A. Felton-Edkins, Niall S. Kenneth, Sarah J. Goodfellow, Dimitris Athineos, Jingxin Zhang, Ben A. Ramsbottom, Fiona Innes, Theodoros Kantidakis, Elaine R. Kerr, Jacqueline Brodie, Carla Grandori, Robert J. White; Activation by c-Myc of transcription by RNA polymerases I, II and III. Biochem Soc Symp 1 January 2006; 73 141–154. doi: https://doi.org/10.1042/bss0730141
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