Defects in the DNA damage response pathways can lead to tumour development. The tumour suppressor p53 is a key player in the DNA damage response, and the precise regulation of p53 is critical for the suppression of tumorigenesis. DNA damage induces the activity of p53, via damage sensors such as ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia-related), which leads to the transcriptional regulation of a variety of genes involved in cell cycle control and apoptosis. p53 is therefore tightly controlled, and its activity is regulated at a multiplicity of levels. An increasing array of cofactors are now known to influence p53 activity. Here we will discuss several of the cofactors that impact on p53 activity, specifically those involved in the function of the two novel p53 cofactors JMY (junction-mediating and regulatory protein) and Strap (serine/threonine-kinase-receptor-associated protein).
Skip Nav Destination
Article navigation
January 2006
Issue Editors
-
Cover Image
Cover Image
Conference Article|
January 01 2006
The p53 response during DNA damage: impact of transcriptional cofactors
Amanda S. Coutts;
Amanda S. Coutts
1Laboratory of Cancer Biology, Division of Medical Sciences, University of Oxford, Oxford OX3 9DU, U.K.
Search for other works by this author on:
Nicholas La Thangue
Nicholas La Thangue
1
1Laboratory of Cancer Biology, Division of Medical Sciences, University of Oxford, Oxford OX3 9DU, U.K.
1To whom correspondence should be addressed (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 181–189.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Amanda S. Coutts, Nicholas La Thangue; The p53 response during DNA damage: impact of transcriptional cofactors. Biochem Soc Symp 1 January 2006; 73 181–189. doi: https://doi.org/10.1042/bss0730181
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Related Articles
Nuclear export factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells
Biochem J (April,2013)
MMP28 gene expression is regulated by Sp1 transcription factor acetylation
Biochem J (April,2010)
A Signal Detection Theory Analysis of the Effect of Chest Cage Restriction upon the Detection of Inspiratory Resistive Loads
Clin Sci (Lond) (April,1983)
The impact of heterochromatin on DSB repair
Biochem Soc Trans (May,2009)