The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerase I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (i) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.
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January 2006
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Conference Article|
January 01 2006
The RNA polymerase I transcription machinery
Jackie Russell;
Jackie Russell
1Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee DD1 5EH, U.K.
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Joost C.B.M. Zomerdijk
1Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee DD1 5EH, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1744-1439
Print ISSN: 0067-8694
© 2006 Biochemical Society
2006
Biochem Soc Symp (2006) 73: 203–216.
Citation
Stefan G.E. Roberts, Robert O.J. Weinzierl, Robert J. White, Jackie Russell, Joost C.B.M. Zomerdijk; The RNA polymerase I transcription machinery. Biochem Soc Symp 1 January 2006; 73 203–216. doi: https://doi.org/10.1042/bss0730203
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