Among the many derivatives of the inositol-based signalling family are a subgroup that possess diphosphates. In this review, some recent research into the actions of these specialized polyphosphates is analysed, and key goals for future studies are identified, which, it is hoped, will result in the wider cell-signalling community giving considerably greater attention to this intriguing but relatively neglected class of inositol polyphosphates.

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Author notes

The Biochemical Society's Annual Symposium, The Cell Biology of Inositol Lipids and Phosphates, was held at the University of Birmingham on 29-31 March 2006.